Category: 630421-73-7

New learning discoveries about 630421-73-7

As the paragraph descriping shows that 630421-73-7 is playing an increasingly important role.

630421-73-7,630421-73-7, 1,6-Dichloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of 1 ,6-dichloroisoquinoline (500 mg, 2.56 mmol)DMSO (5 mL) at RT, piperazine-2-carboxamide (425.6 mg, 2.56 mmol) and K2C03 (1.05 g, 7.68 mmol). The reaction mixture was heated at 80C for 5 h. The reactionmixture was diluted with ethyl acetate and washed with brine. The organic layer was dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The residue was purified by flash colunm chromatography on silica gel (ethyl acetate/petroleum ether1:5) to afford the desired product (80 mg, 12% yield). ESI-MS m/z: 291[M + H].

As the paragraph descriping shows that 630421-73-7 is playing an increasingly important role.

Reference£º
Patent; ARAXES PHARMA LLC; JANES, Matthew, Robert; PATRICELLI, Matthew, Peter; LI, Liansheng; REN, Pingda; LIU, Yi; (397 pag.)WO2016/44772; (2016); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

Simple exploration of 630421-73-7

630421-73-7 1,6-Dichloroisoquinoline 23595199, aisoquinoline compound, is more and more widely used in various fields.

630421-73-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630421-73-7,1,6-Dichloroisoquinoline,as a common compound, the synthetic route is as follows.

The following compounds were dissolved in a mixed solution of 100 ml of toluene, 50 ml of ethanol, and 50 ml of a 2-normal aqueous sodium carbonate solution. Compound 3-1: 4.0 g (20.2 mmol)Compound B3-1: 3.96 g (22.2 mmol)In the resulting reaction solution, 1.17 g (1.01 mmol) of tetrakis(triphenylphosphine)palladium(0) was added while the reaction solution was stilTed in a nitrogen atmosphere at a room temperature. The reaction solution was heated to 60 degrees Celsius and then stilTed for 6 hours. After the reaction was completed, water was added in the reaction solution. The organic layer was extracted with toluene and dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off under reduced pressure. The residue was partially purified by column chromatography (gel used in chromatography: BW300 (produced by Fuji Silysia Chemical Ltd.), developing solvent: ethyl acetate/heptane = 1/3) and washed with methanol. Thus, 5.98 g (yield 100%) of a crude product of Compound 3-2 was prepared.

630421-73-7 1,6-Dichloroisoquinoline 23595199, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; CANON KABUSHIKI KAISHA; ABE, Shigemoto; KAMATANI, Jun; KISHINO, Kengo; SAITOH, Akihito; YAMADA, Naoki; KOSUGE, Tetsuya; HORIUCHI, Takayuki; NISHIDE, Yosuke; MIYASHITA, Hirokazu; WO2014/115528; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

Some tips on 630421-73-7

630421-73-7 1,6-Dichloroisoquinoline 23595199, aisoquinoline compound, is more and more widely used in various.

630421-73-7,630421-73-7, 1,6-Dichloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

1,6-dichloroisoquinoline (4.80 g, 24.2 mmol), 2,6-dimethyl-8-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuro[2,3-b]pyridine (8.22 g, 25.4 mmol), sodium carbonate (6.42 g, 60.6 mmol), palladium tetrakis (0.84 g, 0.73 mmol), 160 mL dimethoxyethane (DME) and 40 mL of water were combined in a round bottom flask. A condenser was attached and then the system was evacuated and purged with nitrogen three times. The reaction mixture was heated to a vigorous reflux overnight. The reaction mixture was diluted with ethyl acetate and water, the suspension was then filtered through Celite and washed with ethyl acetate. The aqueous portion was partitioned off and the organic was washed once with brine, dried with sodium sulfate, filtered, and concentrated down to beige solid. The Celite was further washed with 50/50 DCM/THF and the filtrate was concentrated and combined with the other crude sample. The combined crude sample was dissolved in DCM and purified with silica gel using DCM to 85/15 DCM/ethyl acetate solvent system to get a pale beige solid. The pale beige solid was triturated in 90/10 heptane/ethyl acetate, then filtered to get a white precipitate of 8-(6-chloroisoquinolin-1-yl)-2,6-dimethylbenzofuro[2,3-b]pyridine (7.8 g, 91% yield).

630421-73-7 1,6-Dichloroisoquinoline 23595199, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Universal Display Corporation; Boudreault, Pierre-Luc T.; Adamovich, Vadim; Yamamoto, Hitoshi; Wendt, Harvey; Xia, Chuanjun; EP2940098; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

 

Analyzing the synthesis route of 630421-73-7

The synthetic route of 630421-73-7 has been constantly updated, and we look forward to future research findings.

630421-73-7, 1,6-Dichloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A solution/suspension of 4,4,5,5-tetramethyl-2-(10-methylfluoranthen-8-yl)-1,3,2-dioxaborolane (26.6 g, 78 mmol), 1,6-dichloroisoquinoline (14 g, 70.7 mmol) and sodium carbonate (18.73 g, 177 mmol) in DME (471 ml) and water (118 ml) was degassed with bubbling nitrogen for 20 min. Tetrakis(triphenylphosphine)palladium (2.451 g, 2.121 mmol) was added and degassing continued for 5 mins. The reaction mixture was heated at 105 C. (reflux) for 8 h. The mixture was allowed to cool overnight. The reaction mixture was filtered and the remaining solids in the flask were washed out with methanol (200-300 ml). The filter cake was washed with water (200 ml), methanol (200 ml), water (200 ml), and then methanol (200 ml). The solids were dried under air for 30 min then under vacuum over the weekend to yield the title compound as a yellow solid (23.63 g, 88%).

The synthetic route of 630421-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Universal Display Corporation; Ji, Zhiqiang; Tsai, Jui-Yi; Dyatkin, Alexey Borisovich; Layek, Suman; Boudreault, Pierre-Luc T.; (175 pag.)US2019/214583; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem