630421-73-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.630421-73-7,1,6-Dichloroisoquinoline,as a common compound, the synthetic route is as follows.
The following compounds were dissolved in a mixed solution of 100 ml of toluene, 50 ml of ethanol, and 50 ml of a 2-normal aqueous sodium carbonate solution. Compound 3-1: 4.0 g (20.2 mmol)Compound B3-1: 3.96 g (22.2 mmol)In the resulting reaction solution, 1.17 g (1.01 mmol) of tetrakis(triphenylphosphine)palladium(0) was added while the reaction solution was stilTed in a nitrogen atmosphere at a room temperature. The reaction solution was heated to 60 degrees Celsius and then stilTed for 6 hours. After the reaction was completed, water was added in the reaction solution. The organic layer was extracted with toluene and dried with anhydrous sodium sulfate. Subsequently, the solvent was distilled off under reduced pressure. The residue was partially purified by column chromatography (gel used in chromatography: BW300 (produced by Fuji Silysia Chemical Ltd.), developing solvent: ethyl acetate/heptane = 1/3) and washed with methanol. Thus, 5.98 g (yield 100%) of a crude product of Compound 3-2 was prepared.
630421-73-7 1,6-Dichloroisoquinoline 23595199, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; CANON KABUSHIKI KAISHA; ABE, Shigemoto; KAMATANI, Jun; KISHINO, Kengo; SAITOH, Akihito; YAMADA, Naoki; KOSUGE, Tetsuya; HORIUCHI, Takayuki; NISHIDE, Yosuke; MIYASHITA, Hirokazu; WO2014/115528; (2014); A1;,
Isoquinoline – Wikipedia
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