Category: isoquinoline

Kumar, Arun published the artcileCatalyst free N-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2 using NaBH4, Category: isoquinoline, the main research area is aromatic aliphatic amine formylation sodium borohydride carbon dioxide.

Herein, a sustainable approach for N-formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas is reported. The developed approach is catalyst free, and does not need pressure or a specialized reaction assembly. The reductive formylation of CO2 with sodium borohydride generates formoxy borohydride species in situ, as confirmed by 1H and 11B NMR spectroscopy. The in situ formation of formoxy borohydride species is prominent in formamide based solvents and is critical for the success of the N-formylation reactions. The formoxy borohydride is also found to promote transamidation reactions as a competitive pathway along with reductive functionalization of CO2 with amine leading to N-formylation of amines.

RSC Advances published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pan, Aaron published the artcileSynergistic Bronsted/Lewis acid catalyzed aromatic alkylation with unactivated tertiary alcohols or di-tert-butylperoxide to synthesize quaternary carbon centers, Product Details of C8H10O2, the main research area is aromatic hydrocarbon ditert butylperoxide acid catalyst regioselective alkylation green; tertiary alc aromatic hydrocarbon acid catalyst regioselective alkylation green; quaternary alkylarene preparation.

Dual Bronsted/Lewis acid catalysis involving environmentally benign, readily accessible protic acid and iron promotes site-selective tert-butylation of electron-rich arenes using di-tert-butylperoxide. This transformation inspired the development of a synergistic Bronsted/Lewis acid catalyzed aromatic alkylation that fills a gap in the Friedel-Crafts reaction literature by employing unactivated tertiary alcs. as alkylating agents, leading to new quaternary carbon centers. Corroborated by DFT calculations, the Lewis acid serves a role in enhancing the acidity of the Bronsted acid. The use of non-allylic, non-benzylic, and non-propargylic tertiary alcs. represents an underexplored area in Friedel-Crafts reactivity.

Chemical Science published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wols, B. A. published the artcileDegradation of 40 selected pharmaceuticals by UV/H2O2, Synthetic Route of 117-96-4, the main research area is UV hydrogen peroxide photolysis pharmaceutical compound degradation; Advanced oxidation process; Hydrogen peroxide; Pharmaceuticals; UV; Water treatment.

The occurrence of pharmaceuticals in source waters is increasing. Although UV advanced oxidation is known to be an effective barrier against micropollutants, degradation rates are only available for limited amounts of pharmaceuticals. Therefore, the degradation of a large group of pharmaceuticals has been studied in this research for the UV/H2O2 process under different conditions, including pharmaceuticals of which the degradation by UV/H2O2 was never reported before (e.g., metformin, paroxetine, pindolol, sotalol, venlafaxine, etc.). Monochromatic low pressure (LP) and polychromatic medium pressure (MP) lamps were used for three different water matrixes. In order to have well defined hydraulic conditions, all experiments were conducted in a collimated beam apparatus Degradation rates for the pharmaceuticals were determined For those compounds used in this research that are also reported in literature, measured degradation results are in good agreement with literature data. Pharmaceutical degradation for only photolysis with LP lamps is small, which is increased by using a MP lamp. Most of the pharmaceuticals are well removed when applying both UV (either LP or MP) and H2O2. However, differences in degradation rates between pharmaceuticals can be large. For example, ketoprofen, prednisolone, pindolol are very well removed by UV/H2O2, whereas metformin, cyclophosphamide, ifosfamide are very little removed by UV/H2O2.

Water Research published new progress about Bicarbonates Role: OCU (Occurrence, Unclassified), OCCU (Occurrence). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Synthetic Route of 117-96-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Singh, Dileep Kumar published the artcileOne-pot, three-component approach to diarylacetonitriles, Formula: C8H10O2, the main research area is aromatic aldehyde heteroarene trimethylsilyl cyanide three component reaction; diarylacetonitrile preparation one pot.

A novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF3-OEt2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, was also demonstrated.

Organic Chemistry Frontiers published new progress about Acetonitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pearson, Colin M. published the artcileA Regio- and Stereodivergent Synthesis of Homoallylic Amines by a One-Pot Cooperative-Catalysis-Based Allylic Alkylation/Hofmann Rearrangement Strategy, Category: isoquinoline, the main research area is perfluorophenyl alkanoate allyl electrophile alkanol tandem alkylation Hofmann rearrangement; methyl alkenyl carbamate diastereoselective enantioselective regioselective preparation; alkylation; amines; ammonium enolates; palladium; rearrangement.

A modular synthetic route to linear and branched homoallylic amines that operates through a sequential one-pot Lewis base/transition-metal catalyzed allylic alkylation/Hofmann rearrangement strategy. This protocol was operationally trivial, proceeded from simple and easily prepared substrates and catalysts and enabled all aspects of regio- and stereoselectivity to be controlled through a conserved exptl. protocol. Overall, the high levels of enantio-, regio- and diastereoselectivity obtained, in concert with the ability to access orthogonally protected or free amines, render this a straightforward and effective approach for the preparation of useful enantioenriched homoallylic amines. The utility of the products in the context of pharmaceutical synthesis were also demonstrated.

Angewandte Chemie, International Edition published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Yangsen published the artcilePhotocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride, Product Details of C8H11NO, the main research area is photocatalytic water splitting coupled alkanol oxidation; nitrogen alkylation palladium carbon nitride catalyst green chem; N-alkylation reaction; alkanol oxidation; carbon nitride; photocatalysis; water splitting.

Photocatalytic water splitting technol. (PWST) enables the direct use of water as appealing “”liquid hydrogen source”” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technol. highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chems. and pharmaceuticals from nitroarenes and amines with water and alkanols.

ChemSusChem published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Biswal, Priyabrata published the artcilePalladium-Catalyzed Synthesis of α-Methyl Ketones from Allylic Alcohols and Methanol, Application In Synthesis of 86-51-1, the main research area is methyl ketone preparation; diaryl propenol alc isomerization methylation palladium catalyst; aryl propenol alc isomerization methylation palladium catalyst.

One-pot synthesis of α-Me ketones RC(O)CH(R1)CH2R2 (R = Ph, 4-methoxyphenyl, naphthalen-2-yl, furan-2-yl, etc.; R1 = Me, Et, n-Bu; R2 = H, Ph, naphthalen-1-yl, thiophen-2-yl, etc.) starting from 1,3-diaryl propenols RCH(OH)CH=CHR2 or 1-aryl propenols RCH(OH)CH=CH2 and methanol as a C1 source is demonstrated. This one-pot isomerization-methylation is catalyzed by com. available Pd(OAc)2 with H2O as the only byproduct. Mechanistic studies and deuterium labeling experiments indicate the involvement of isomerization of allyl alc. followed by methylation through a hydrogen-borrowing pathway in these isomerization-methylation reactions.

Advanced Synthesis & Catalysis published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Chuangchuang published the artcileBF3·OEt2-promoted tandem Meinwald rearrangement and nucleophilic substitution of oxiranecarbonitriles, Synthetic Route of 104-01-8, the main research area is cyano aryloxirane nucleophile acid tandem Meinwald rearrangement nucleophilic substitution; benzeneacetamide preparation regioselective microwave irradiation green chem; aryl acetic acid preparation regioselective microwave irradiation green chem; phenylacetate preparation regioselective microwave irradiation green chem.

Tandem Meinwald rearrangement and nucleophilic substitution of oxiranenitriles was realized. Arylacetic acid derivatives were readily synthesized from 3-aryloxirane-2-carbonitriles with amines, alcs., or water in the presence of boron trifluoride under microwave irradiation, and the designed synthetic strategy includes introducing a cyano leaving group into arylepoxides and capturing the in-situ generated toxic cyanide with boron trifluoride, making the reaction efficient, safe and environmentally benign. The reaction occurred through an acid-promoted Meinwald rearrangement, producing arylacetyl cyanides, followed by an addition-elimination process with nitrogen or oxygen-containing nucleophilic amines, alcs. or water. The current method provided a new application of the tandem Meinwald rearrangement.

Organic & Biomolecular Chemistry published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Synthetic Route of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Braun, Carolin published the artcilePlanar-chiral [2.2]Paracyclophane-based Pyridonates as Ligands for Tantalum-catalyzed Hydroaminoalkylation, HPLC of Formula: 5961-59-1, the main research area is planar chiral paracyclophane pyridonate ligand tantalum catalyzed hydroaminoalkylation.

By using planar chiral [2.2]paracyclophane-containing N,O-chelating ligands for tantalum-catalyzed hydroaminoalkylation, one of the most versatile catalytic systems for this reaction to date was obtained [e.g., 4-methoxy-N-methylaniline + 1-octene I (90%)]. Convenient Csp3-Csp3 bond formation of amines with terminal and internal alkenes was enabled by the same in situ synthesized catalytic system of [2.2]paracyclophane-based pyridonates and Ta(CH2TMS)3Cl2 that shows also very promising results for N-containing heterocycles.

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (internal). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vayer, Marie published the artcilePotassium Carbonate to Unlock a GaCl3-Catalyzed C-H Propargylation of Arenes, COA of Formula: C8H10O2, the main research area is electron rich arene bromoallene carbon hydrogen propargylation; gallium chloride catalyst potassium carbonate base.

A gallium-catalyzed C-H propargylation of electron-rich arenes using bromoallenes is described. The development of this reaction was first hampered by a side hydroarylation process catalyzed by adventitious protons, easily generated from the solvent (1,2-dichloroethane). This hidden Bronsted acid catalysis could be bypassed by using K2CO3 as insoluble base. The unexpected compatibility of this base with the Lewis acid catalyst GaCl3 allowed a strictly gallium-catalyzed process that was thoroughly studied by kinetics, 71Ga NMR experiments and DFT computations. The GaCl3/K2CO3 system triggers the C-H propargylation of a wide range of arenes and heteroaromatics using a variety of bromoallenes.

ACS Catalysis published new progress about Alkynes, aryl Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem