Category: isoquinoline

Ebbrell, David J. published the artcileValidation of a Fragment-Based Profiler for Thiol Reactivity for the Prediction of Toxicity: Skin Sensitization and Tetrahymena pyriformis, Name: 5-Methyl-2-phenylhex-2-enal, the main research area is skin sensitization aquatic toxicity human health.

This study outlines the use of a recently developed fragment-based thiol reactivity profiler for Michael acceptors to predict toxicity towards Tetrahymena pyriformis and skin sensitization potency as determined in the Local Lymph Node Assay (LLNA). The results showed that the calculated reactivity parameter from the profiler, -log RC50(calc), was capable of predicting toxicity for both endpoints with excellent statistics. However, the study highlighted the importance of a well-defined applicability domain for each endpoint. In terms of Tetrahymena pyriformis this domain was defined in terms of how fast or slowly a given Michael acceptor reacts with thiol leading to two sep. quant. structure-activity models. The first, for fast reacting chems. required only 1Log RC50(calc) as a descriptor, while the second required the addition of a descriptor for hydrophobicity. Modeling of the LLNA required only a single descriptor, -log RC50(calc), enabling potency to be predicted. The applicability domain excluded chems. capable of undergoing polymerization and those that were predicted to be volatile. The modeling results for both endpoints, using the 1log RC50(calc) value from the profiler, were in keeping with previously published studies that have utilized exptl. determined measurements of reactivity. This results demonstrate the output from the fragment-based thiol reactivity profiler can be used to develop quant. structure-activity relationship models where reactivity towards thiol is a driver of toxicity.

Chemical Research in Toxicology published new progress about Aquatic toxicity. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Name: 5-Methyl-2-phenylhex-2-enal.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wendel, Friedrich M. published the artcileTransformation of Iopamidol during Chlorination, Recommanded Product: Diatrizoic Acid, the main research area is transformation iopamidol water chlorination.

The transformation of the iodinated x-ray contrast media (ICM) iopamidol, iopromide, iohexol, iomeprol, and diatrizoate was examined in purified water over the pH 6.5-8.5 in the presence of Na hypochlorite, monochloramine, and ClO2. In the presence of aqueous Cl, only iopamidol was transformed. All other ICM did not show significant reactivity, regardless of the oxidant used. Chlorination of iopamidol followed a 2nd order reaction, with an observed rate constant of up to 0.87/M-s (±0.021/M-s) at pH 8.5. The hypochlorite anion was identified to be the reactive Cl species. Iodine was released during the transformation of iopamidol, and was mainly oxidized to iodate. Only a small percentage (<2% after 24 h) was transformed to known organic iodinated disinfection byproducts (DBPs) of low mol. weight Some of the I was still present in high-mol. weight DBPs. The chem. structures of these DBPs were elucidated via MSn fragmentation and NMR. Side chain cleavage was observed as well as the exchange of I by Cl. An overall transformation pathway was proposed for the degradation of iopamidol. CHO cell chronic cytotoxicity tests indicate that chlorination of iopamidol generates a toxic mixture of high mol. weight DBPs (LC50 332 ng/μL). Environmental Science & Technology published new progress about Aquatic toxicity. 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Recommanded Product: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Yunling published the artcile2D molecular sheets of hydrogen-bonded organic frameworks for ultrastable sodium-ion storage, Synthetic Route of 1455-77-2, the main research area is hydrogen bonded organic framework sodium ion secondary battery; chemical stability; hydrogen-bonded organic frameworks; molecular sheets; multi-site hydrogen bonds; sodium ion storage.

There has been growing research interest in hydrogen bonded organic frameworks (HOFs) by virtue of their great structural crystallinity, large surface areas and porosity. Their potential in electrochem. applications, unfortunately, remains elusive because weak hydrogen bonds would dissociate in solution that eventually compromises the structural integrity. Herein, it is demonstrated that this issue may be overcome by designing and introducing multisite hydrogen bonding within HOFs. 2D mol. sheets are prepared using diaminotriazole as the linkers for the first time. In spite of the mol. thickness (≈1 nm), they are chem. stable and mech. robust, and have diminished solubility in most polar or nonpolar organic solvents. This solution-stable HOF exhibits an excellent electrochem. performance for Na+ ion storage. In particular, it enables an exceptional cycle life of >10 000 cycles at 1 A g-1, which is far superior to most other organic electrode materials. Theor. simulations indicate that the activation barrier for the intralayer or interlayer diffusion of Na+ ions within the organic frameworks is small.

Advanced Materials (Weinheim, Germany) published new progress about Battery cathodes. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Synthetic Route of 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Yunling published the artcile2D molecular sheets of hydrogen-bonded organic frameworks for ultrastable sodium-ion storage, Synthetic Route of 1455-77-2, the main research area is hydrogen bonded organic framework sodium ion secondary battery; chemical stability; hydrogen-bonded organic frameworks; molecular sheets; multi-site hydrogen bonds; sodium ion storage.

There has been growing research interest in hydrogen bonded organic frameworks (HOFs) by virtue of their great structural crystallinity, large surface areas and porosity. Their potential in electrochem. applications, unfortunately, remains elusive because weak hydrogen bonds would dissociate in solution that eventually compromises the structural integrity. Herein, it is demonstrated that this issue may be overcome by designing and introducing multisite hydrogen bonding within HOFs. 2D mol. sheets are prepared using diaminotriazole as the linkers for the first time. In spite of the mol. thickness (≈1 nm), they are chem. stable and mech. robust, and have diminished solubility in most polar or nonpolar organic solvents. This solution-stable HOF exhibits an excellent electrochem. performance for Na+ ion storage. In particular, it enables an exceptional cycle life of >10 000 cycles at 1 A g-1, which is far superior to most other organic electrode materials. Theor. simulations indicate that the activation barrier for the intralayer or interlayer diffusion of Na+ ions within the organic frameworks is small.

Advanced Materials (Weinheim, Germany) published new progress about Battery cathodes. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Synthetic Route of 1455-77-2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jeon, Byoungjun published the artcileA development of a graph-based ensemble machine learning model for skin sensitization hazard and potency assessment, Product Details of C11H12O3, the main research area is graph ensemble machine learning skin sensitization hazard potency assessment; KeratinoSens™; defined approach; direct peptide reactivity assay; graph neural network; human cell line activation test; integrated testing strategy; machine learning; risk assessment; skin sensitization.

Many defined approaches (DAs) for skin sensitization assessment based on the adverse outcome pathway (AOP) have been developed to replace animal testing because the European Union has banned animal testing for cosmetic ingredients. Several DAs have demonstrated that machine learning models are beneficial. In this study, we have developed an ensemble prediction model utilizing the graph convolutional network (GCN) and machine learning approach to assess skin sensitization. The model integrates in silico parameters and data from alternatives to animal testing of well-defined AOP to improve DA predictivity. Multiple ensemble models were created using the probability produced by the GCN with six physicochem. properties, direct peptide reactivity assay, KeratinoSens, and human cell line activation test (h-CLAT), using a multilayer perceptron approach. Models were evaluated by predicting the testing set ′s human hazard class and three potency classes (strong, weak, and non-sensitizer). When the GCN feature was used, 11 models out of 16 candidates showed the same or improved accuracy in the testing set. The ensemble model with the feature set of GCN, KeratinoSens, and h-CLAT produced the best results with an accuracy of 88% for assessing human hazards. The best three-class potency model was created with the feature set of GCN and all three assays, resulting in 64% accuracy. These results from the ensemble approach indicate that the addition of the GCN feature could provide an improved predictivity of skin sensitization hazard and potency assessment.

Journal of Applied Toxicology published new progress about Bayesian network. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Hao published the artcileNitrogen heterocyclic/phosphaphenanthrene derivative as a reactive additive for simultaneous improvement of flame retardancy, mechanical and dielectric properties of epoxy resins, Name: 3,5-Diamino-1,2,4-triazole, the main research area is nitrogen based reactive additive improve phys property epoxy resin.

Various approaches have been successfully applied to solve the flammability of epoxy resin (EP) materials, but enhanced flame retardance of EP is often along with deteriorated glass transition temperature (Tg) and mech. property. In order to prepare EP composites with good comprehensive performance, we synthesized a phosphorus-containing triazole derivative named TBO from 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, 3,5-diamino-triazole and salicylaldehyde, and attached it into epoxy framework. With 0.75 wt% phosphorus loading, the 0.75-TBO/EP composite had a V-0 rating and a limiting oxygen index of 33%. 1.0-TBO/EP composite also had a V-0 rating and acquired a decrease of 37.6% in peak heat release rate. In addition, the tensile strength and flexural strength of 0.75-TBO/EP increased to 63.9 MPa and 146 MPa from 59 MPa and 134 MPa of EP resp. Meanwhile, the Tg values of TBO/EP elevated to some certain compared to EP. In a word, EP modified with TBO composites owned strong mech. property, higher Tg and excellent flame retardance, indicating great potential for application.

Polymer Degradation and Stability published new progress about Bending strength. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Name: 3,5-Diamino-1,2,4-triazole.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Hao published the artcileNitrogen heterocyclic/phosphaphenanthrene derivative as a reactive additive for simultaneous improvement of flame retardancy, mechanical and dielectric properties of epoxy resins, Category: isoquinoline, the main research area is nitrogen based reactive additive improve phys property epoxy resin.

Various approaches have been successfully applied to solve the flammability of epoxy resin (EP) materials, but enhanced flame retardance of EP is often along with deteriorated glass transition temperature (Tg) and mech. property. In order to prepare EP composites with good comprehensive performance, we synthesized a phosphorus-containing triazole derivative named TBO from 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide, 3,5-diamino-triazole and salicylaldehyde, and attached it into epoxy framework. With 0.75 wt% phosphorus loading, the 0.75-TBO/EP composite had a V-0 rating and a limiting oxygen index of 33%. 1.0-TBO/EP composite also had a V-0 rating and acquired a decrease of 37.6% in peak heat release rate. In addition, the tensile strength and flexural strength of 0.75-TBO/EP increased to 63.9 MPa and 146 MPa from 59 MPa and 134 MPa of EP resp. Meanwhile, the Tg values of TBO/EP elevated to some certain compared to EP. In a word, EP modified with TBO composites owned strong mech. property, higher Tg and excellent flame retardance, indicating great potential for application.

Polymer Degradation and Stability published new progress about Bending strength. 1455-77-2 belongs to class isoquinoline, name is 3,5-Diamino-1,2,4-triazole, and the molecular formula is C2H5N5, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maadwar, Sasikala published the artcileA facile and an efficient synthesis of 3, 3-disubstituted oxindole scaffolds and their cytotoxic properties, Category: isoquinoline, the main research area is diphenyl indolinone preparation antitumor activity SAR.

3,3-Disubstituted oxindole derivatives I [R = H, Me, Cl, etc.; R1 = 1,2-dimethoxy, 1,3-dimethoxy, 1,4-dimethoxy, 1,3,5-trimethoxy] were synthesized by treating isatins with electron rich benzene derivatives at room temperature by using BF3·O(Et)2 as catalyst which reduced the synthesis time. The compounds I were evaluated for cytotoxic activity against human breast cancer cells (MCF7) and human ovarian carcinoma cells (SKVO3) by using MTT assay. Compounds I [R = Cl, Br; R1 = 1,3,5-trimethoxy] (7.2±0.22μM and 11.80.21±μM), 2(7.10.24±μM and 9.8±0.27μM), exhibited relatively higher cytotoxic activity against both MCF7 and SKVO3 cell lines, resp.

International Research Journal of Pharmacy published new progress about Antitumor agents. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yamani, Abdellah published the artcileDiscovery and optimization of novel pyrazole-benzimidazole CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors FGFR (1-3), Application In Synthesis of 151-10-0, the main research area is pyrazolyl benzimidazole preparation antitumor docking FGFR inhibitor; Anti-tumor activity; FGFR (1–3) inhibitor; Pyrazole-benzimidazole.

The scaffolds hybridization approach, scaffold-hopping concept, has been employed to synthesize a series of novel pyrazole-benzimidazoles I [R1 = H, Cl; R2 = morpholin-4-yl, 4-methylpiperazin-1-ylcarbonyl, tetrahydropyran-4-ylcarbamoyl, etc.; R3 = H, F]. Compound I [R1 = R3 = H; R2 = 4-methylpiperazin-1-yl] (CPL304110) was identified as a selective and potent pan-FGFR inhibitor for FGFR1, FGFR2, FGFR3 with IC50 of 0.75 nM, 0.50 nM, 3.05 nM resp., and IC50 of 87.90 nM for FGFR4. Due to its favorable pharmacokinetic profile, low toxicity and potent anti-tumor activity in-vivo, this compound I is currently under evaluation in phase I clin. trial for the treatment of bladder, gastric and squamous cell lung cancers (01FGFR2018; NCT04149691).

European Journal of Medicinal Chemistry published new progress about Antitumor agents. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Guangzhe published the artcileTotal synthesis and biological evaluation of 7-hydroxyneolamellarin A as hypoxia-inducible factor-1α inhibitor for cancer therapy, Application of 4-Methoxyphenylacetic acid, the main research area is hydroxyneolamellarin antitumor agent HIF alpha inhibitor; 7-Hydroxyneolamellarin A; Anti-tumor; HIF-1α inhibition; Total synthesis.

7-Hydroxyneolamellarin A (7-OH-Neo A, 1), a natural marine product derived from sponge Dendrilla nigra, was first synthesized with 10% overall yield under the instruction of convergent synthetic strategy. We found that 7-Hydroxyneolamellarin A could attenuate the accumulation of hypoxia-inducible factor-1α (HIF-1α) protein and inhibit vascular epidermal growth factor (VEGF) transcriptional activity, showing well inhibitory effect on HIF-1 signaling pathway. Meantime, 7-Hydroxyneolamellarin A had the well anti-tumor activities, such as inhibiting tumor angiogenesis, proliferation, migration and invasion. More importantly, 7-Hydroxyneolamellarin A exhibited profound anti-tumor effect in mice breast cancer model by suppressing the accumulation of HIF-1α in tumor tissue. Mechanism study demonstrated that 7-Hydroxyneolamellarin A might target the protein with the ability of stabilizing HIF-1α in hypoxia. Due to the excellent water solubility, superior anti-tumor activity and good biocompatibility, 7-OH-Neo A shows the promising potential for being exploited as an anti-tumor agent in near future.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem