Category: isoquinoline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

[00191] Isoquinoline-6-carbohydrazide: Isoquinoline-6-carboxylic acid (1.2 g,6.94 mmol) purchased from Gateway Chemical Technology, Inc. was mixed with CDI (1.68 g, 10.4 mmol) in DMF (20 Ml) in a round bottom flask. After the mixture was stirred for 30 minutes at 2O0C, anhydrous hydrazine (2 mL) was added and the resulting mixture was stirred at 2O0C for one hour. After removing the solvent at a reduced pressure, the remaining residue was mixed with 20 mL water. After filtration, washing with water and air drying, an off-white solid was obtained as the desired product. LCMS (API-ES) m/z (%): 188.0 (100%, M++H).

106778-43-2, The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; AMGEN INC.; WO2009/11880; (2009); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.51206-40-7,1,4-Dibromoisoquinoline,as a common compound, the synthetic route is as follows.,51206-40-7

Dibromoisoquinoline (5, 29 mg, 0.1 mmol) Example 1, step 1, and M-NH2 (0.2 mmol) in 8-mL vial were heated in 1 mL of n-butanol at 90 C. for 36 hrs. The mixture was cooled to room temperature and the solvent was evaporated under reduced pressure. 4-Mercaptopyridine (23 mg, 0.2 mmol) and cesium carbonate (67 mg, 0.2 mmol) were added to the vial. The mixture was heated at 180 C. for 1 hr and was allowed to cool to room temperature. Methanol (2 mL) was added to the vial and the mixture was sonicated for 10 min and filtered. The methanol solution of reaction mixture was collected and evaporated under reduced pressure. The formation of product was confirmed by LC/MS. The invention compounds of Examples 83-92 as shown in the below table were prepared by method B-1.

51206-40-7 1,4-Dibromoisoquinoline 640981, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US6689883; (2004); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.90806-58-9,5-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.,90806-58-9

General procedure: The mixture of isoquinoline 1 (1.3 mmol), terminal alkyne 2 (1.0 mmol), methylperfluoroalk-2-ynoates 3 (1.5 mmol), and CuBr (0.1 mmol) was stirred in toluene (5 mL) under N2. After stirring at room temperature for 24 h, CuBr2 (0.2 mmol), pyridine (1.0 equiv) were added. The mixture was stirred at 100 C under air for an additional 16 h. Then, the reaction was quenched with water and extracted with ethyl acetate (3¡Á5 mL). The combined extracts were washed with brine, dried over anhydrous Na2SO4, and filtered. The filtrate was concentrated. The crude product was purified by flash chromatography on a silica gel (eluent: petroleum ether /ethylacetate) to give pure 5a-5q.

As the paragraph descriping shows that 90806-58-9 is playing an increasingly important role.

Reference£º
Article; Tao, Lili; Xu, Zhiliang; Han, Jing; Deng, Hongmei; Shao, Min; Chen, Jie; Zhang, Hui; Cao, Weiguo; Synthesis; vol. 48; 23; (2016); p. 4228 – 4236;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1109230-25-2, 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[001081 A mixture of 5-bromo-3,4-dihydro-2H-isoquinolin-1-one (Preparation 3-1, 4.3 g, 18.9 mmol) and 2,3-dicyano-5,6-dichloro-1,4-benzoquinone (8.6 g, 37.9 mmol) in 1,4-dioxane (76 mL) was stirred at 100 C for 24 h. The reaction mixture was evaporated and the residue was taken up in ethyl acetate (500 mL) and washed with 10% aqueous sodium hydroxide (2 x 500 mL). The layers were separated and the aqueous layer was extracted with ethyl acetate (4 x 300 mL). The combined organic layers were dried over sodium sulfate, evaporated and purified by flash chromatography eluting with dichloromethane:methanol (99:1 -96:4) to give the title compound (1.49 g, 6.65 mmol, 35%) as a yellow solid. LCMS: 94%, Rt 1.243, ESMS m/z 224 (M+H)., 1109230-25-2

The synthetic route of 1109230-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; OBSCHESTVO S OGRANICHENNOY OTVETSTVENNOST’YU “PANACELA LABS”; GUROVA, Katerina; RYDKINA, Elena Borisovna; WADE, Warren; WO2015/50471; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.82827-09-6,6-Bromoisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

82827-09-6, 6-Bromoisoquinoline-1 (2Eta)-one (12mm0l), bis(4-methoxyphenyl)disulfide (10mmol), hexafluorofluoride was sequentially added to the pressure resistant reaction tube at room temperature. Silver acid (10 mmol) and dichloroethene (6 mL) were applied. Then the reaction mixture is at 90 C Reaction for 10 hours. The reaction was stopped, concentrated under reduced pressure to give a crude material, which was washed with a mixture of petroleum ether and ethyl acetate. 4-(4-Methoxyphenylthio)-6-bromoisoquinoline-1 (2H)-one. Yield 95%;

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Nankai University; Zhu Youquan; He Jingli; Niu Yunxia; Han Tingfeng; Li Haoyu; (14 pag.)CN108822035; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

82827-09-6,82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

C. 6-Bromo-1-Chloroisoquinoline 6-Bromoisoquinolin-1-one (2.54 g, 11 mmol) is converted to the title compound (2.69 g, 11 mmol) by the method described in EXAMPLE 23, Part C. 1 H NMR (CDCl3, 300 MHz) delta8.30 (d, 1H), 8.19 (d, 1H), 8.04 (s, 1H), 7.78 (d, 1H), 7.52 (d, 1H), 7.27 (s, 1H), 6.49 (d, 1H). EI MS, M+ =241, 243.

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Rhone-Poulenc Rorer Pharmaceuticals Inc.; US5731315; (1998); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

66491-03-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66491-03-0,7-Amino-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

Example 2) l-MethyI-lH-pyrazoIe-3-sulfonic acid (4-chloro-benzyl)-(2-ethyl-l- oxo-1 ,2,3,4-tetrahydro-isoquinolin-7-yl)-amide (METHOD B)i) 7-Benzylamino-3,4-dihydro-2H-isoquinolin-l-one Sodium triacetoxyborohydride (1.29 g, 6.16 mmol) was added to a stirred solution of 7-amino-3,4-dihydro-2H-isoquinolin-l-one (500 mg, 3.08 mmol), 4- chlorobenzaldehyde (431 mg, 3.0S mmol) and acetic acid (183 mul, 3.08 mmol) in anhydrous dichloromethane (25 ml) at room temperature. The reaction was stirred overnight and quenched with the addition of water. The organic phase was separated, washed with brine, then dried (MgSO4) and evaporated in vacuo. The resulting residue was purified by flash column chromatography (50% ethyl acetate in dichloromethane) to yield the title compound as a pale yellow solid (287 mg, 16%). HPLC retention time 4.09min. Mass spectrum (ES+) m/z 287 (M+H).

The synthetic route of 66491-03-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; XENTION LIMITED; HAMLYN, Richard, John; MADGE, David; MULLA, Mushtaq; WO2010/139953; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

Reference Preparation Example Homopiperazine (3.413 g) was dissolved in tetrahydrofuran (57 ml) with stirring. After cooling the solution to -5 C, 5-isoquinolinesulfonyl chloride hydrochloride (3.00 g) was added while maintaining the intemal temperature at 10 C or less. The mixture was stirred at 5 C or less for four hours. The reaction mixture was allowed to stand to reach room temperature and filtered to remove insoluble matter. The filtrate was concentrated under reduced pressure, followed by the addition of ethyl acetate (57 ml), water (17 ml), and 3 N hydrochloric acid aqueous solution (6.4 ml). The mixture was separated into layers to obtain a water layer. After washing the water layer with ethyl acetate (7 ml), water (6 ml), ethyl acetate (57 ml), and 6 N sodium hydroxide aqueous solution (3 ml) were added to separate the mixture into layers and obtain an organic layer. The organic layer was concentrated under reduced pressure and the residue was dried under reduced pressure to obtain fasudil (1.36 g). The yield was 41%. The fasudil is processed by the method described in JP-A-9-71582 to obtain fasudil hydrochloride. Fasudil can also be obtained in the same manner using the solvents listed below instead of tetrahydrofuran used in the Reference Preparation Example at yields described in the parentheses. Acetone (22%), acetonitrile (30%), 1,2-dimethoxyethane (31%), 2-butanone (24%), anisole (34%), isopropyl ether (10%), ethyl acetate (38%), toluene (18%), etc. Concentration of the filtrate was unnecessary when anisole, isopropyl ether, ethyl acetate, and toluene were used as the solvent., 105627-79-0

As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; Asahi Kasei Pharma Corporation; EP1726306; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

679433-91-1, 5-Bromo-8-methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,679433-91-1

To a mixture of l-bromo-5-methoxynaphthalene1 (320 mg, 1.3 mmol) and 4-aminophenylboronic acid (HCl salt, 320 mg, 1.85 mmol) in dioxane (3 mL)-H20 (3 mL) was added PdCl2(dppf)-dichloromethane (53 mg, 0.063 mmol) and Na2CO3 (530 mg, 4.2 mmol). The mixture was heated to 1000C for 12 h and cooled to room temperature. The mixture was extracted with dichloromethane and the organic phase was dried over Na2SO^ concentrated, and purified on silica with 5% (2N NH3 in MeOH) in dichloromethane to afford the product as a tan solid (300 mg, 89%). MS (ESI pos. ion) m/z: 251 (M+H).

As the paragraph descriping shows that 679433-91-1 is playing an increasingly important role.

Reference£º
Patent; AMGEN INC.; WO2007/5668; (2007); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18881-17-9,(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol,as a common compound, the synthetic route is as follows.,18881-17-9

To an ice cooled solution of 5-bromo-2-(3-(ethoxycarbonyl)-5-methyl-lH-pyrazol-l-yl)benzoic acid (45.0 g, 127.8 mmol) in DCM (450 mL) were added (5)-(l ,2,3,4-tetrahydroisoquinolin-3-yl)methanol (20.8 g, 102.27 mmol), HATU (72.7 g, 191.2 mmol), DIPEA (55.7 mL, 319.6 mmol) followed by stirring at RT for 12h. The reaction mixture was diluted with DCM (750 mL), washed with water (500 mL), brine (100 mL), dried over sodium sulphate and concentrated invacuo. The residue was purified on silica gel (100-200 mesh) to afford the the title compound as a liquid 50 g (79%). Rf = 0.44 (55 % EtOAc in hexane); NMR (400 MHz, DMSO-d6): delta 8.00 – 7.40 (m, 3H), 7.30 – 7.00 (m, 4H), 6.80 – 6.40 (m, 1H), 5.10 – 3.80 (m, 7H), 3.50 – 2.40 (m, 3H), 2.40 – 2.10 (m, 3H), 1.30 – 1.00 (m, 3H); ES-MS: m/z 498.2 (M+H).

18881-17-9 (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol 776757, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; NOVARTIS AG; FORD, Daniel; PORTER, John Robert; VISSER, Michael Scott; YUSUFF, Naeem; WO2013/96051; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem