Category: isoquinoline

93117-08-9,93117-08-9, 5-Aminoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a solution of the appropriate amine (1.0mmol) in THF was added pyridine (1.1mmol) and phenyl chloroformate (1.0mmol) at 0C and stirred at room temperature for 1h. The reaction mixture was quenched with water and extracted with EtOAc several times. The combined organic layer was washed with brine, dried with MgSO4, filtered and concentrated in vacuo. The residue was purified by silica gel colunm chromatography to afford the desired product.

93117-08-9 5-Aminoisoquinolin-1(2H)-one 2072, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Lee, Hobin; Ahn, Songyeon; Ann, Jihyae; Ha, Heejin; Yoo, Young Dong; Kim, Young Ho; Hwang, Ji-Young; Hur, Kwang-Hyun; Jang, Choon-Gon; Pearce, Larry V.; Esch, Timothy E.; Lewin, Nancy E.; Blumberg, Peter M.; Lee, Jeewoo; European Journal of Medicinal Chemistry; vol. 182; (2019);,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

18881-17-9, (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

18881-17-9, Compound 62 (5.3 g, 16.47 mmol) and (S)-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol (2.96 g,18.12 mmol) were dissolved in dichloromethane (47.1 mL). The reaction mixture was cooled to0 C and triethylamine (3.44 mL, 24.71 mmol) was added dropwise under Ar. The reaction mixturewas then warmed to room temperature and was stirred overnight. The solution was concentratedand the crude product was purified by silica gel chromatography (ethyl acetate/hexanes, gradient,0% to 80%) to obtain compound 12 (7.22 g, 16.10 mmol, 98% yield).

As the paragraph descriping shows that 18881-17-9 is playing an increasingly important role.

Reference£º
Article; Reid, Emily E.; Archer, Katie E.; Shizuka, Manami; McShea, Molly A.; Maloney, Erin K.; Ab, Olga; Lanieri, Leanne; Wilhelm, Alan; Ponte, Jose F.; Yoder, Nicholas C.; Chari, Ravi V.J.; Miller, Michael L.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 17; (2019); p. 2455 – 2458;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.622867-52-1,tert-Butyl 6-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.,622867-52-1

Example 4: [6-Dimethylaminomethyl-3,4-dihydro-2( 1 H)isoquinolin-2-yl]( 1 -methyl- 1 H-indol-2-yl)methanone:(1) Production of 1,1-dimethylethyl 6-(t-butyldiphenylsilyloxymethyl)-3,4-dihydro-2(lH)- isoquinolinecarboxylate: T-butyldiphenylchlorosilane (557 mg, 2.03 mmol) and imidazole (288 mg, 4.22 mmol) were added in an N,N-dimethylformamide (6 mL) solution of 1,1-dimethylethyl 3,4-dihydro-6- (hydroxymethyl)-2(lH)-isoquinolinecarboxylate (445 mg, 1.69 mmol), and the mixture was stirred overnight at room temperature. The reaction liquid was diluted with ethyl acetate (20 mL), and washed with water and saturated brine. The organic layer was dried with magnesium sulfate, and the solvent was evaporated off under reduced pressure. The residue was purified through silica gel column chromatography to give the entitled compound (975 mg, 100 %) as a colorless oil.

622867-52-1 tert-Butyl 6-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate 59132278, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; BANYU PHARMACEUTICAL CO.,LTD.; HAGA, Yuji; MIZUTANI, Sayaka; SATO, Nagaaki; WO2010/126164; (2010); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20232-39-7,6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride,as a common compound, the synthetic route is as follows.

In a 100-ml two-necked round bottom flask equipped with a mechanical stirrer, an addition funnel and an argon in/outlet, 5.0 g of 1 was suspended in 19 ml of heptane at room temperature. 19 ml of 2-PrOH was added over 15 minutes and stirring was continued for 1 h. A 200-ml four-necked round bottom flask equipped with a mechanical stirrer, an addition funnel and an argon in/outlet, was charged with 7.4 g of 2, 268.0 mg of NaOAc and 1.9 ml of H2O in 56 ml of 2-PrOH. To this mixture was added over 1.5 h the previously prepared emulsion and, after 1 h, 333 mul, of conc. aqueous HCl was added. 55 ml of heptane was added over 30 minutes. The yellow suspension was stirred for 2 h at room temperature, filtered and washed portionwise with 12 ml of 2-PrOH and 24 ml of heptane (cooled to 0¡ã C.). Evaporation of the solvent and drying under high vacuum gave 10.23 g (84percent) of 3c as an off-white solid.

20232-39-7, 20232-39-7 6,7-Dimethoxy-3,4-dihydroisoquinoline hydrochloride 2724664, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Abrecht, Stefan; Adam, Jean-Michel; Fettes, Alec; Hildbrand, Stefan; US2008/71087; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27655-40-9,Isoquinoline-5-sulfonic acid,as a common compound, the synthetic route is as follows.

a 5-Isoquinolinesulfonyl chloride A mixture of 5-isoquinolinesulfonic acid (4.18 g, 20 mmol), and phosphorus pentachloride (6.24 g, 30 mmol) in phosphorus oxychloride (20 mL) was heated at 120 C. for two days. The reaction mixture was cooled to room temperature and diluted with dry chloroform (60 mL). The white precipitate was collected, washed with dry chloroform, and dried under high vacuum to give the title compound as a white solid (4.40 g, 83%) which was used for next step without further purification. 1H-NMR (300 MHz, CDCl3)delta9.95 (s, 1H), 9.16 (d, J=6.8 Hz, 1H), 8.74 (d, J=6.8 Hz, 1H), 8.52 (t, J=7.0 Hz, 2H), 7.99 (t, J=7.3 Hz, 1H).

27655-40-9, As the paragraph descriping shows that 27655-40-9 is playing an increasingly important role.

Reference£º
Patent; 3-Dimensional Pharmaceuticals, Inc.; US6235778; (2001); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

82827-09-6, 6-Bromoisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

82827-09-6, To a solution of 6-bromoisoquinolin-1(2H)-one (0.5 g, 2.23 mmol) in DMA (10 mL), wasadded NaH (60%, 0.13 g, 3.34 mmol) at room temperature and the mixture was stirred for 30mi 4-methoxybenzyl chloride (0.52 g, 3.34 mmol) was added to the reaction mixture at room temperature. The reaction mixture was stirred at rt for 3 h. Progress of the reaction was monitored by TLC. The reaction mixture was diluted with water (100 mL) and extracted with EtOAc (2 x 50 mL). The organic layers were separated, dried (Na2SO4), filtered and concentratedto afford 130 (1.02 g, crude) as a brown semisolid. This material was used for the next step without further purification. MS (ESl + ye): 344.04. 1H-NMR (400 MHz; DMSO-d6): oe 8.12 (d, J = 8.56 Hz, 1H), 7.94 (s, 1H), 7.65-7.62 (m, 2H), 7.30-7.26 (m, 2H), 6.91-6.87 (m, 2H), 6.61 (d, J = 7.32 Hz, 1H), 5.08 (s, 2H), 3.72 (s, 3H).

The synthetic route of 82827-09-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CARDIO THERAPEUTICS PTY LTD; TREUTLEIN, Herbert; ZENG, Jun; DIXON, Ian; JAMES, Ian; PALMER, James T; (169 pag.)WO2018/165718; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13130-79-5,1-Bromoisoquinolin-3-amine,as a common compound, the synthetic route is as follows.

A mixture of 1-bromoisoquinolin-3-amine (400 mg, 1.79 mmol, 1.00 eq) and tert-butoxycarbonyl tert-butyl carbonate (3.91 g, 17.9 mmol, 4.12 mL, 10.0 eq) was stirred at 70¡ã C. for 16 hours. The residue was purified by column chromatography (SiO 2, diethyl ether/ethyl acetate=5:1) to give tert-butyl N-(1-bromo-3-isoquinolyl) carbamate (400 mg, 1.24 mmol, 69.2% yield) as a yellow solid. ESI MS m/z 322.1, 324.1 [M+H] +.

13130-79-5, 13130-79-5 1-Bromoisoquinolin-3-amine 289845, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Mirati Therapeutics, Inc.; Array BioPharma Inc.; Blake, James F.; Burgess, Laurence E.; Chicarelli, Mark Joseph; Christensen, James Gail; Cook, Adam; Fell, Jay Bradford; Fischer, John P.; Marx, Matthew Arnold; Mejia, Macedonio J.; Savechenkov, Pavel; Vigers, Guy P.A.; Smith, Christopher Ronald; Rodriguez, Martha E.; US2019/144444; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

925672-85-1, 1,6-Dibromoisoquinolin-3-amine is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,925672-85-1

Step 1 To a mixture of 1,6-dibromoisoquinolin-3-amine (XVIII)(0.5 g, 1.66 mmol), ammonium formate-d5 (0.56 g, 8.28 mmol)and Pd(PPh3)4 (191.3 mg, 0.170 mmol)in DMF (5 mL)was heated to 50 C. for 48 h. The solvents were concentrated and the residue was suspended in chloroform. The solid was collected by filtration and washed with water and EtOAc. The solid were dried under high vacuo to obtain 6-bromo-1-deuterio-isoquinolin-3-amine (XIX)(115 mg,0.513 mmol, 31.0% yield)as a pale yellow solid. 1H NMR (500 MHz, DMSO-d6)delta ppm 6.11 (2H, s), 6.55 (1H, s), 7.22 (1H, dd, J=8.78, 1.92 Hz), 7.73 (1H, d, J=8.51 Hz), 7.79 (1H, d, J=1.92 Hz); ESIMS found for C9H6DBrN2 m/z 224.0 (79BrM+H).

As the paragraph descriping shows that 925672-85-1 is playing an increasingly important role.

Reference£º
Patent; Samumed, LLC; KC, Sunil Kumar; Mak, Chi Ching; Eastman, Brian Walter; Cao, Jianguo; Bollu, Venkataiah; Mittapalli, Gopi Kumar; Chiruta, Chandramouli; (218 pag.)US2017/313682; (2017); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.105627-79-0,Isoquinoline-5-sulfonyl chloride hydrochloride,as a common compound, the synthetic route is as follows.

2) In 1000 L in the reactor are separately put into dichloromethane 500 L, homopiperazine 50 kg and liquid ammonia 33 kg, stirring solution cleaning, adding step 1) obtained FZ010 – 1. In the 10 C insulation reaction to the TLC detection without FZ010 – 1 residue when the end of the reaction, the reaction time is 2 – 4 H-. The reaction […] purified water 300 L, stir, fully after standing, divide the methylene chloride level. The aqueous layer then 100 L methylene chloride extraction, repeating the extraction of two, then the collection of methylene chloride level; to-methylene chloride layer in purified water 300 L, dropwise 4 mol/L hydrochloric acid solution to adjust system for pH 4.5 – 5.0, during the dropping temperature of not higher than 40 C, layered; collecting water layer, mass fraction of 20% NaOH solution to adjust the pH of the aqueous layer to 8.0, during the dropping temperature of not higher than 40 C. For 200 L methylene chloride extraction, repeating the extraction of 3 times, then the collection of methylene chloride level, vacuum distillation, to obtain yellowish sticks the thick oil objects, about 21.8 kg, is the intermediate hexahydro -1 – (5 – isoquinoline sulfonyl) – 1 H – 1, 4 – benzodiazepine salt (formula (I) in the FZ010 – 2), yield is 54.5%.

105627-79-0, As the paragraph descriping shows that 105627-79-0 is playing an increasingly important role.

Reference£º
Patent; Henan Runhong Pharmaceutical Co., Ltd.; Cui Hailong; Ma Liyan; Wang Xiaoxue; Shi Yongzhi; An Xiaomin; Shi Huifeng; Zhang Wei; (8 pag.)CN109574992; (2019); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

66491-03-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66491-03-0,7-Amino-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

Example 4: (/?)-4-Methyl-2-(l-oxo-l,2,3,4-tetrahydro-isoquinolin-7-ylamino)-7- (propane-2-sulfonyl)-4,ll-diaza-tricyclo[14.2.2.1^’1″]henicosa- l(19),6,8,10(21),16(20),17-hexaene-3,12-dione trifluoroacetic acid salt; Intermediate 1 (128 mg, 0.789 mmol),3G (400 mg, 0.751 mmol), and glyoxylic acid monohydrate (69.2 mg, 0.751 mmol) were dissolved in acetonitrile (2.25 mL) and DMF (1.75 mL) to give a yellow solution. The mixture was irradiated in a microwave reactor at 100 0C for 10 min, then was concentrated. The crude product was purified by flash chromatography (1 to 20% MeOH/CH2Cl2 gradient) to afford 380 mg (71.6 %) of 4A as a yellow glass. (ESI) m/z 707 ‘.2 (M+H)+.

66491-03-0 7-Amino-3,4-dihydroisoquinolin-1(2H)-one 13152844, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2008/79836; (2008); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem