Category: isoquinoline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-05-9,6-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

The A6-1 (210mg, 1.01mmol) was dissolved in tetrahydrofuran (10mL), was added bis (pinacolato) borate (305mg, 1.20mmol), KOAc(294mg, 3.00mmol), Pd (dppf) 2Cl2 (80mg, 0.10mmol), purged with nitrogen, refluxed overnight, cooled to room temperature, suction filtered through Celite,The filtrate was spin-dried, the residue was purified by column chromatography (petroleum ether: ethyl acetate = 4: 1) to give a yellow gummy solid (270mg, 106%).

As the paragraph descriping shows that 34784-05-9 is playing an increasingly important role.

Reference£º
Patent; Suzhou Yunxuan Pharmaceutical Co., Ltd.; Zhang, Xiaohu; (54 pag.)CN105254613; (2016); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

7651-81-2, Isoquinolin-3(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: The desired alcohol intermediate (p83-86 as reported in the table, 1 eq) was dissolved in THF (-40 vol). PP (1.5 eq) was added, followed by the desired phenol (commercially available, 1.5 eq). The mixture was stirred at RT for 15′, then cooled to 0 C. DIAD (1.5 eq) was added dropwise and, after 10′, the ice bath was removed and the mixture was allowed to reach RT and stirred for at that temperature for 1.5-2.5 hrs. The mixture was concentrated and the crude obtained was purified by FC on silica gel and/or NH column (eluting mixture Cy/AcOEt) and/or C18 cartridge (eluent from water + 0.1 % formic acid / MeCN + 0.1 % formic acid) to afford the title compound.

The synthetic route of 7651-81-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; CHRONOS THERAPEUTICS LIMITED; MICHELI, Fabrizio; BERTANI, Barbara; GIBSON, Karl Richard; DI FABIO, Romano; RAVEGLIA, Luca; ZANALETTI, Riccardo; CREMONESI, Susanna; POZZAN, Alfonso; SEMERARO, Teresa; TARSI, Luca; LUKER, Timothy Jon; (275 pag.)WO2019/43407; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

A solution of 70 (30 mg, 0.13 mmol, leq) and triethylamine (0.65 mmol, 5 eq.) in THF (2 mL) was added to a solution of commercially available isoquinoline-3-carboxylic acid (22 mg, 0.13 mmol) and HATU (50 mg, 0.13 mmol) in THF (2 mL). The reaction was stirred for 3h at 60¡ãC, then cooled to room temperature and poured into water-ice. The product was extracted with EtOAc, dried (MgS04), filtered and concentrated. The crude product was purified by column chromatography on silica gel (ethyl acetate-hexanes) to afford the product as a white powder in 39percent yield; mp 228-230 ¡ãC. XH NMR (400 MHz, DMSO-i?) delta 11.99 (s, 2H), 9.51 (s, 1H), 8.77 (s, 1H), 8.34 (d, J= 7.33 Hz, 1H), 8.29 (d, J= 8.06 Hz, 1H), 7.87 – 7.99 (m, 2H), 7.66 (s, 1H), 7.56 (d, J= 2.01 Hz, 1H), 7.53 (dd, J= 1.92, 8.33 Hz, 1H), 7.03 (d, J= 8.42 Hz, 1H), 3.85 (s, 3H), 3.80 (s, 3H); LCMS (ESI) m/z 392 (MH+)

The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; RENSLO, Adam R.; GALLARDO-GODOY, Alejandra; SILBER, B. Michael; PRUSINER, Stanley B.; GILES, Kurt; LI, Zhe; NEITZ, R. Jeffrey; WO2013/33037; (2013); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

34784-05-9, 6-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

D. 1-[(3,3-Dimethyl-3-silabutoxy)methyl]-5-(6-isoquinolyl)-2-(phenylsulfonyl)imidazole. To a solution of 6-bromoisoquinoline (73 mg, 0.35 mmol) in anhydrous DMF (0.75 mL) was added copper(II) oxide (28 mg, 0.35 mmol). The mixture was purged with nitrogen, tetrakis(triphenylphosphine)palladium(0) (55 mg, 0.048 mmol) was added, and then the materials were stirred at 100 C. for 5 minutes in a sealed vial. The vial was cooled to room temperature and then a solution of 5-(1,1-dibutyl-1-stannapentyl)-1-[(3,3-dimethyl-3-silabutoxy)methyl]-2-(phenylsulfonyl)imidazole (200 mg, 0.3.19 mmol) in anhydrous DMF (0.25 mL) was added. The mixture was purged with nitrogen then the sealed reaction was stirred at 105 C. for 8 hours. The reaction was cooled to room temperature, filtered through celite, and the celite rinsed with ethyl acetate. The filtrate was diluted with water, extracted three times with dichloromethane, and the organic layers combined. The organic solution was washed with brine, dried over anhydrous magnesium sulfate, filtered, and volatiles evaporated. The material was purified by chromatography on a normal phase silica gel column with 30 to 100% ethyl acetate in hexanes. Fractions containing clean product were combined and the solvent evaporated. The material was dried under vacuum at 60 C. to provide the title compound (1.2 g, 87%). MS (ESI) m/z 466.2 [M+1]+.

As the paragraph descriping shows that 34784-05-9 is playing an increasingly important role.

Reference£º
Patent; D’Sidocky, Neil R.; Harris, Roy L.; Hegde, Sayee G.; Hilgraf, Robert; McCarrick, Margaret A.; McKie, Jeffrey A.; Mortensen, Deborah S.; Nadolny, Lisa; Perin-Ninkovic, Sophie M.; Sapienza, John J.; Wright, Jonathan L.; US2008/242694; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

105627-79-0, Isoquinoline-5-sulfonyl chloride hydrochloride is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 8 In 100 ml of ice water was dissolved 10.6 g of 5-isoquinolinesulfonyl chloride hydrochloride, and the pH of the solution was adjusted to 6 with a saturated aqueous sodium hydrogencarbonate solution, followed by extraction with of 200 ml of dichloromethane. The dichloromethane layer was added dropwise to a 100 ml of dichloromethane solution containing 6.0 g of 3-hydroxypiperidine and 6.0 g of triethylamine over 30 minutes while cooling with ice. The mixture was stirred at a temperature of 15 C. to 20 C. for 3 hours, washed with water, and dried with anhydrous magnesium sulfate. Then, the dichloromethane was removed under reduced pressure to obtain 8.50 g of 1-(5-isoquinolinesulfonyl)-3-hydroxypiperidine.

105627-79-0 Isoquinoline-5-sulfonyl chloride hydrochloride 13116932, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Asahi Kasei Kogyo Kabushiki Kaisha; US4798897; (1989); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-65-3,Isoquinoline,as a common compound, the synthetic route is as follows.

5-Bromo-8-nitroisoquinoline. Isoquinoline (15 ml; 128 mmol) was slowly added to a mechanically stirred solution of concentrated H2SO4 (130 ml) (Note 1) at -20 C., at such a speed that the temperature did not exceed +8 C. The reaction mixture was then re-cooled to -20 C., and solid N-bromosuccinimide (27.29 g; 153 mmol) (Note 2 and 3) was added at such a speed that the reaction temperature did not exceed -15 C. (Note 4). The reaction mixture was stirred at -20 C. until all isoquinoline was consumed (Note 5). Solid KNO3 (13 g; 128 mmol) was added in one portion, whereby the reaction temperature warmed up to -12 C. to -10 C. The reaction was stirred at -10 C. to -20 C. for 2 hours and then allowed to warm up to rt. The reaction mixture was poured onto 650 g of crushed ice and pH adjusted to 7.0 (Note 6) using 25% NH3 (aq.), while the temperature was kept below +30 C. The mixture was left for precipitation for 1 h at rt. The yellow precipitate was isolated by filtration, washed on the filter with H2O (3*500 ml) and then dried by suction followed by air drying to give 27.1 g crude product. (Note 7).

As the paragraph descriping shows that 119-65-3 is playing an increasingly important role.

Reference£º
Patent; NeuroSearch A/S; US6500954; (2002); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-65-3,Isoquinoline,as a common compound, the synthetic route is as follows.

General procedure: To an 8 mL dram vial was added iodobenzene diacetate (0.6 mmol, 1.5 equiv), and heteroarene(0.4 mmol, 1 eq.), anhydrous dichloroethane (1 mL), then chloride source (5 equiv). The solutionwas allowed to stir (1000 rpm) at 50 C for the indicated amount of time. After which the solutionwas washed with saturated sodium bicarbonate, followed by saturated sodium thiosulfate andconcentrated. The crude mixture was then purified by column chromatography.

As the paragraph descriping shows that 119-65-3 is playing an increasingly important role.

Reference£º
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

491-30-5, 1-Hydroxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2.90 g, 19.07 mMol of isocarbostyril and 14.40 g, 33.68 mMol of phosphorus pentabromide were allowed to melt together at 140 C. The melt turned into a red liquid and after about 10 minutes the reaction mixture solidified and was cooled. The reaction mixture was crushed up and dumped into ice water. The resulting solid was filtered and air-dried. wt. 5.50 g, 96% yield, mp.=94-96. Rf=0.66 in 40% ethyl acetate in hexanes.

As the paragraph descriping shows that 491-30-5 is playing an increasingly important role.

Reference£º
Patent; Bayer Pharmaceuticals Corporation; US6689883; (2004); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1075-11-2,6-Fluoroisoquinoline,as a common compound, the synthetic route is as follows.

Example 13 1-chloro-6-fluoro-isoquinoline; To a solution of 6-fluoroisoquinoline (2.64 g, 17.9 mmol) in CH2Cl2 (70 mL) cooled at 0 C., MCPBA is added (3.4 g, 19.69 mmol). The reaction mixture is stirred at RT for 16 h. After 1 h of stirring, a yellow white precipitate forms. The solvent is evaporated under reduced pressure. To the yellow solid is added CH2Cl2 (5 mL), and the solid is isolated by vacuum filtration. Rinsing the solid with CH2Cl2 yields a white solid, which is dried under vacuum to afford 3 g (100%) of 6-fluoro-isoquinoline N-oxide.

1075-11-2 6-Fluoroisoquinoline 21889847, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Huang, Kenneth He; Veal, James; Barta, Thomas; Smith, Emilie D.; Ma, Wei; Ommen, Andy; US2008/70935; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1075-11-2, 6-Fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

In general, the 6-fluoro and 6-alkyl isoquinolines used in the following experiments were prepared via a Pomeranz-Fritsch synthesis (Typical procedure: Preparation of optically active 8,8-disubstituted 1, 1-biisoquinoline, K.Hirao, R. Tsuchiya, Y. Yano, H. Tsue, Heterocycles 42(1) 1996,415-422) as outlined below. The products were converted into the 1-chloro derivatives via N-oxide intermediates as described elsewhere. General Synthetic Scheme EMI271.1Reagents and reaction conditions: (a) reflux in benzene, azeotropic removal of water; (b) first step: ethyl chloroformate, trimethyl phosphite in THF, second step: titanium tetrachloride in chloroform; (c) MCPBA inCH2CI2 ; (d) POCl3 in benzene

The synthetic route of 1075-11-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2003/99274; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem