Category: isoquinoline

1075-12-3, 7-Fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Dimethylsulfamoyl chloride (34; 0.144 mL, 1.34 mmol) was added to a solution of isoquinoline (5; 157 mg, 1.22 mmol) and 1H-indol-7-yl acetate (33; 213 mg, 1.22 mmol) in toluene (4 mL) at r.t. The mixture was concentrated to a thick but stirrable paste (1.5 mL), which was stirred at 50 C for 3 h. TLC and LCMS showed reaction was largely complete by this time. The mixture was diluted with EtOAc (40 mL), washed with H2O (40 mL) and sat. brine (20 mL), dried (Na2SO4), filtered and evaporated to dryness. The residue was purified by flash silica gel chromatography (loading in CH2Cl2) (eluent: gradient 20 to 50% EtOAc in heptane). Fractions containing the desired product were evaporated to afford the title compound 37a (208 mg, 42%) as a white solid

The synthetic route of 1075-12-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Pearson, Stuart E.; Fillery, Shaun M.; Goldberg, Kristin; Demeritt, Julie E.; Eden, Jonathan; Finlayson, Jonathan; Patel, Anil; Synthesis; vol. 50; 24; (2018); p. 4963 – 4981;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of isoquinoline-3-carboxylic acid monohydrate (63 g, 0.364 mol) and Na2SO4 (10 g) in dry DMF (200 mL) was treated with DIEA (76 mL, 0.44 mol). The reaction mixture was stirred at rt for 20 min and cooled to 0¡ã C. followed by drop wise addition of Intermediate 17 (147 g, 0.36 mol) in DMF (200 ml). The mixture was stirred for 2 h at 0¡ã C. and then diluted with ice water and filtered. The collected solid was washed with water then dissolved in EtOAc. The organic phase was washed with saturated aqueous NaHCO3, then water, dried over Na2SO4 and concentrated. Hexane trituration afforded Intermediate 18 (155 g) (Isoquinoline-3-carboxylic acid 2-{3-[(R)-1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-nitro-phenyl}-2-oxo-ethyl ester) as a white solid. 1H NMR (CDCl3): delta 9.34(1H), 8.68(1H), 8.08(2H), 8.01(1H), 7.80(2H), 7.75 (2H), 7.36(2H), 7.04(2H), 6.72(1H), 5.70(2H), 5.32(1H), 1.61(3H) ppm. LC/MS: m/z 503 (M+2)+

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Reference£º
Patent; Mjalli, Adnan M.M.; Cooper, Jeremy T.; Arimilli, Murty N.; Andrews, Robert C.; Rothlein, Robert; AlTel, Taleb H.; US2007/219239; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: The tail group containing dimer or trimer (0.266 mmol) wasdissolved in methanol (25 mL), to which Pd/C-10percent (60 mg) wasadded at 0 C under nitrogen with stirring. The reaction mixturewas hydrogenated at room temperature and atmospheric pressurefor 4 h. The catalyst was removed over Kieselguhr and the solventwas removed under reduced pressure to give the amine, which wasdissolved in DMF (1 mL, dry). The appropriate head group carboxylic acid (0.266 mmol) was dissolved in DMF (1 mL, dry) towhich HBTU (260 mg, 0.685 mmol) and triethylamine (50 mL) wereadded to the reaction mixture at room temperature with stirringand the reaction mixture was left standing at room temperatureovernight. The product was purified by HPLC (no work up required).Fractions containing the product were collected and freeze dried togive the required product.

The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Scott, Fraser J.; Khalaf, Abedawn I.; Giordani, Federica; Wong, Pui Ee; Duffy, Sandra; Barrett, Michael; Avery, Vicky M.; Suckling, Colin J.; European Journal of Medicinal Chemistry; vol. 116; (2016); p. 116 – 125;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

General procedure: At 0 ¡ãC and with stirring to the solution of 865 mg (5.0 mmol) of isoquinoline-3-carboxylic acid in 10 ml of anhydrous THF 675 mg (5.0 mmol) of HOBt was added to form reaction mixture A. The solution of 5.5 mmol of l-amino acid benzylester in 5 ml of anhydrous THF was adjusted pH 9 with triethylamine and stirred for 30 min to form mixture B. At 0 ¡ãC the mixtures A and B were mixed and then 1339 mg (6.5 mmol) of DCC was added. The reaction mixture was stirred at 0 ¡ãC for 2 h, at room temperature for12 h and TLC (ethyl acetate/petroleum ether, 1:2) indicated the complete disappearance of isoquinoline-3-carboxylic acid. The formed precipitates of DCU were removed by filtration and the filtrate was evaporated under vacumm. The residue was dissolved in 50 ml of ethyl acetate and the formed solution was washed successively with saturated aqueous solution of NaHCO3 (30 ml .x. 3), 5percent aqueous solution of KHSO4 (30 ml .x. 3) and saturated aqueous solution of NaCl (30 ml .x. 3) and dried over anhydrous Na2SO4. After filtration the filtrate was evaporated under vacumm and the residure was purified on silica gel chromatography (CHCl3:MeOH, 20:1) to give the title compounds.

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Article; Zheng, Meiqing; Yang, Yifan; Zhao, Ming; Zhang, Xiaoyi; Wu, Jianhui; Chen, Gong; Peng, Li; Wang, Yuji; Peng, Shiqi; European Journal of Medicinal Chemistry; vol. 46; 5; (2011); p. 1672 – 1681;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

27655-40-9, Isoquinoline-5-sulfonic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Weigh 5g of raw materials A (5-sulfoisoquinoline), placed in 50ml round bottom flask, followed by adding 0.5ml DMF, 25ml of sodium sulfoxide, 80 C reflux reaction 3h. To room temperature, evaporated under reduced pressure of sodium sulfoxide and DMF,Add 20ml of ethyl acetate dissolved, filtered,Ethyl acetate solvent was evaporated to dryness to give the intermediate product B (5- isoquinoline sulfonyl chloride).

27655-40-9 Isoquinoline-5-sulfonic acid 241599, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; Shanxi Curecell Biotechnology Co., Ltd.; Li, Xuechun; (14 pag.)CN106146467; (2016); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-26-5,6-Aminoisoquinoline,as a common compound, the synthetic route is as follows.

K3PO4 (0.544 g, 2.565 mmol), Pd2(dba)3 (0.049 g, 0.0534 mmol) and Xantphos (0.052 g, 0.0891 mmol) were added to a solution of intermediate 13 (0.168 g, 0.891 mmol) in THF (6 mL) while nitrogen was bubbling. After 10 min, isoquinolin-6-amine (0.128 g, 0.891 mmol) was added and the mixture was stirred at rt for 10 min. Then, the mixture was heated at 100 ¡ãC for 16 h. More Pd2(dba)3 (0.049 g, 0.0534 mmol) and Xantphos (0.052 g, 0.0891 mmol) were added under nitrogen flow, and the mixture was heated again at 100 ¡ãC overnight. Pd2(dba)3 (0.049 g, 0.0534 mmol) and Xantphos (0.052 g, 0.0891 mmol) were added were added under nitrogen flow, and the mixture was heated again at 100 ¡ãC for 6 h. The mixture was washed with sat. NaHC03 and extracted with EtOAc. The org layers were dried over MgS04, filtered and the solvent was evaporated in vacuo. The crude product was purified by flash column chromatography (silica; EtOAc in DCM 0/100 to 45/55). The desired fractions were collected and concentrated in vacuo. The product was purified by preparative HPLC (from 75percent [25 mM (0216) NH4HC03] – 25percent [ACN: MeOH 1 : 1] to 0percent [25 mM NH4HC03] – 100percent [ACN: MeOH 1 : 1]). The desired fractions were collected and the solvent was evaporated. The residue was dissolved in DCM and HC1 (5 M in 2-propanol) was added and the resulting mixture was concentrated in vacuo. The residue was triturated with Et20 and filtered to yield compound 7 as an orange solid (0.066 g, 22percent yield). FontWeight=”Bold” FontSize=”10″ H NMR (300 MHz, DMSO-de) delta ppm 1.83 – 2.05 (m, 2 H) 3.17 (br t, J=6.8 Hz, 2 H) 4.58 (dt, J=47.4, 5.8 Hz, 2 H) 5.83 (br s, 1 H) 7.00 (d, J=8.8 Hz, 1 H) 7.12 (dd, J=8.7, 2.7 Hz, 1 H) 7.77 (dd, J=9.2, 1.2 Hz, 1 H) 7.81 (d, J=2.5 Hz, 1 H) 7.99 (d, J=6.9 Hz, 1 H) 8.20 (d, J=9.1 Hz, 1 H) 8.28 (d, J=6.6 Hz, 1 H) 8.42 (s, 1 H) 9.30 (s, 1 H) 10.08 (s, 1 H)

As the paragraph descriping shows that 23687-26-5 is playing an increasingly important role.

Reference£º
Patent; JANSSEN PHARMACEUTICA NV; ANDRES-GIL, Jose, Ignacio; BORMANS, Guy, Maurits, R.; DECLERCQ, Lieven, Denis, Herwig; FIERENS, Katleen; LEENAERTS, Joseph, Elisabeth; MOECHARS, Diederik, Willem, Elisabeth; ROMBOUTS, Frederik, Jan, Rita; KOLB, Hartmuth; ZHANG, Wei; (67 pag.)WO2018/15307; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-26-5,6-Aminoisoquinoline,as a common compound, the synthetic route is as follows.

A mixture of tert-butyl (1S,2R)-2-(5-bromo-6-cyanopyridin-3¡¤¡¤ylanilino)cyclohexylcarbamate (90 mg, 0,227 mmol), 6-aminoisoquinoline (40 mg, 0.277 mmol), NaOPh trihydrate (50 mg, 0.294 mmol), xantphos (30 rng, 0.051 mmol) and Pd2dba3 (18 mg, 0.019 mmol) in dioxane (3 mL) was degassed with Ar, then was stirred at 110 ¡ãC for 20 h. The mixture was concentrakd in vacuo. The residue was then dissolved in trifluoroacetic acid (5 mL). The solution was allowed to stand for 30 min. Excess of trifluoroacetie acid vvas removed in vacuo. The residue was purified by HPLC to give 5-((1R,2S)-2-aminocyclohexylamino)-3-(isoquinolin-6-ylamino)picolinonitrile (85 mg).

As the paragraph descriping shows that 23687-26-5 is playing an increasingly important role.

Reference£º
Patent; PORTOLA PHARMACEUTICALS, INC.; SONG, Yonghong; XU, Qing; SRAN, Arvinder; BAUER, Shawn M.; JIA, Zhaozhong J.; KANE, Brian; PANDEY, Anjali; WO2013/192046; (2013); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

491-30-5, 1-Hydroxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

A mixture of 2.90 g, 19.07mMol of isocarbostyril and 14.40 g, 33.68mMol of phosphorus pentabromide were allowed to melt together at 140 C. The melt turned into a red liquid and after about 10 minutes the reaction mixture solidified and was cooled. The reaction mixture was crushed up and dumped into ice water. The resulting solid was filtered and air-dried. wt. 5.50 g, 96% yield, mp.=94-96. Rf=0.66 in 40% ethyl acetate in hexanes.

491-30-5 1-Hydroxyisoquinoline 10284, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; BAYER CORPORATION; EP1228063; (2009); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1075-11-2, 6-Fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Dimethylsulfamoyl chloride (34; 0.144 mL, 1.34 mmol) was added to a solution of isoquinoline (5; 157 mg, 1.22 mmol) and 1H-indol-7-yl acetate (33; 213 mg, 1.22 mmol) in toluene (4 mL) at r.t. The mixture was concentrated to a thick but stirrable paste (1.5 mL), which was stirred at 50 C for 3 h. TLC and LCMS showed reaction was largely complete by this time. The mixture was diluted with EtOAc (40 mL), washed with H2O (40 mL) and sat. brine (20 mL), dried (Na2SO4), filtered and evaporated to dryness. The residue was purified by flash silica gel chromatography (loading in CH2Cl2) (eluent: gradient 20 to 50% EtOAc in heptane). Fractions containing the desired product were evaporated to afford the title compound 37a (208 mg, 42%) as a white solid

As the paragraph descriping shows that 1075-11-2 is playing an increasingly important role.

Reference£º
Article; Pearson, Stuart E.; Fillery, Shaun M.; Goldberg, Kristin; Demeritt, Julie E.; Eden, Jonathan; Finlayson, Jonathan; Patel, Anil; Synthesis; vol. 50; 24; (2018); p. 4963 – 4981;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3336-43-4,1-Chloroisoquinolin-4-ol,as a common compound, the synthetic route is as follows.

To a solution of l-chloro-4-hydroxyisoquinoline (1.Og, 5.6 mmol) in DMF (16mL), was added 6-chloronicotmonitrile (0.55g, 4.0mmol) and K2CO3 (1.65g, 11.9mmol). The reaction mixture was heated at 7O0C for 6.5h. Solvent was removed in vacuo and residue partitioned between EtOAc (10OmL), THF (10OmL) and water (6OmL). The organic phase was washed with water (2x60mL), IM NaOH (2x40mL), brine (4OmL) and dried (MgSO4). Solvent was removed in vacuo to give the title compound: RT = 3.66min; m/z (ES+) = 282.0 [M + H]+.

3336-43-4 1-Chloroisoquinolin-4-ol 4281882, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; PROSIDION LIMITED; WO2008/142454; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem