Analyzing the synthesis route of 3336-43-4

3336-43-4 1-Chloroisoquinolin-4-ol 4281882, aisoquinoline compound, is more and more widely used in various.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3336-43-4,1-Chloroisoquinolin-4-ol,as a common compound, the synthetic route is as follows.

To a solution of l-chloro-4-hydroxyisoquinoline (1.Og, 5.6 mmol) in DMF (16mL), was added 6-chloronicotmonitrile (0.55g, 4.0mmol) and K2CO3 (1.65g, 11.9mmol). The reaction mixture was heated at 7O0C for 6.5h. Solvent was removed in vacuo and residue partitioned between EtOAc (10OmL), THF (10OmL) and water (6OmL). The organic phase was washed with water (2x60mL), IM NaOH (2x40mL), brine (4OmL) and dried (MgSO4). Solvent was removed in vacuo to give the title compound: RT = 3.66min; m/z (ES+) = 282.0 [M + H]+.

3336-43-4 1-Chloroisoquinolin-4-ol 4281882, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; PROSIDION LIMITED; WO2008/142454; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem