6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A mixture of isoquinoline-3-carboxylic acid monohydrate (63 g, 0.364 mol) and Na2SO4 (10 g) in dry DMF (200 mL) was treated with DIEA (76 mL, 0.44 mol). The reaction mixture was stirred at rt for 20 min and cooled to 0¡ã C. followed by drop wise addition of Intermediate 17 (147 g, 0.36 mol) in DMF (200 ml). The mixture was stirred for 2 h at 0¡ã C. and then diluted with ice water and filtered. The collected solid was washed with water then dissolved in EtOAc. The organic phase was washed with saturated aqueous NaHCO3, then water, dried over Na2SO4 and concentrated. Hexane trituration afforded Intermediate 18 (155 g) (Isoquinoline-3-carboxylic acid 2-{3-[(R)-1-(4-fluoro-phenyl)-ethylcarbamoyl]-5-nitro-phenyl}-2-oxo-ethyl ester) as a white solid. 1H NMR (CDCl3): delta 9.34(1H), 8.68(1H), 8.08(2H), 8.01(1H), 7.80(2H), 7.75 (2H), 7.36(2H), 7.04(2H), 6.72(1H), 5.70(2H), 5.32(1H), 1.61(3H) ppm. LC/MS: m/z 503 (M+2)+
#N/A
Reference£º
Patent; Mjalli, Adnan M.M.; Cooper, Jeremy T.; Arimilli, Murty N.; Andrews, Robert C.; Rothlein, Robert; AlTel, Taleb H.; US2007/219239; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem