With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-65-3,Isoquinoline,as a common compound, the synthetic route is as follows.
5-Bromo-8-nitroisoquinoline. Isoquinoline (15 ml; 128 mmol) was slowly added to a mechanically stirred solution of concentrated H2SO4 (130 ml) (Note 1) at -20 C., at such a speed that the temperature did not exceed +8 C. The reaction mixture was then re-cooled to -20 C., and solid N-bromosuccinimide (27.29 g; 153 mmol) (Note 2 and 3) was added at such a speed that the reaction temperature did not exceed -15 C. (Note 4). The reaction mixture was stirred at -20 C. until all isoquinoline was consumed (Note 5). Solid KNO3 (13 g; 128 mmol) was added in one portion, whereby the reaction temperature warmed up to -12 C. to -10 C. The reaction was stirred at -10 C. to -20 C. for 2 hours and then allowed to warm up to rt. The reaction mixture was poured onto 650 g of crushed ice and pH adjusted to 7.0 (Note 6) using 25% NH3 (aq.), while the temperature was kept below +30 C. The mixture was left for precipitation for 1 h at rt. The yellow precipitate was isolated by filtration, washed on the filter with H2O (3*500 ml) and then dried by suction followed by air drying to give 27.1 g crude product. (Note 7).
As the paragraph descriping shows that 119-65-3 is playing an increasingly important role.
Reference£º
Patent; NeuroSearch A/S; US6500954; (2002); B1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem