Heterocyclic Building Blocks-Isoquinoline

Isoquinoline is a heterocyclic aromatic organic compound. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. Product Details of C9H6BrN.

Vijeta, Arjun;Casadevall, Carla;Reisner, Erwin research published 《 An Integrated Carbon Nitride-Nickel Photocatalyst for the Amination of Aryl Halides Using Sodium Azide》, the research content is summarized as follows. A photocatalytic protocol for the selective synthesis of primary anilines RNH₂ [R = Ph, 4-BrC₆H₄, 3-pyridyl, etc.] via cross-coupling of a wide range of aryl/heteroaryl halides with sodium azide using a photocatalyst powder consisting of nickel(II) deposited on mesoporous carbon nitride (Ni-mpg-CN_x) was reported. This heterogeneous photocatalyst contained a high surface area with a visible light-absorbing and adaptive “built-in” solid-state ligand for the integrated catalytic Ni site. The method displayed a high functional group tolerance, required mild reaction conditions, and benefited from easy recovery and reuse of the photocatalyst powder. Thereby, it overcame the need of complex ligand scaffolds required in homogeneous catalysis, precious metals and elevated temperatures/pressures in existing protocols of primary anilines synthesis. The reported heterogeneous Ni-mpg-CN_x held potential for applications in the academic and industrial synthesis of anilines and exploration of other photocatalytic transformations.

Product Details of C9H6BrN, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Isoquinoline is a heterocyclic aromatic organic compound. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. It is a structural isomer of quinoline. Isoquinoline and quinoline are benzopyridines, which are composed of a benzene ring fused to a pyridine ring. Application of C9H6BrN.

Tian, Wan-Fa;He, Ke-Han;Li, Na;Fen;Liu;Mai, Xi;Feng, Li-Hua;He, Yong-Qin research published 《 Transition-Metal-Free Coupling Reactions: PPh₃-Promoted Sonogashira-Type Cross-Couplings of Heteroaryl Halides with Terminal Alkynes》, the research content is summarized as follows. Synthesis phenylethynyl heteroaryl I [Ar¹ = 2-pyridyl, 6-Me-3-pyridyl, 3-quinolyl, etc.; Ar² = Ph 2-FC₆H₄, 4-MeOC₆H₄, etc.] via Sonogashira-type cross-coupling reaction of heteroaryl halides with terminal alkynes under mild transition-metal-free conditions using PPh₃ and Cs₂CO₃/NEt₃ was reported, a wide range of functional groups was tolerated under optimized conditions. Furthermore, the protocol would be extended to the Suzuki-type cross-coupling of heteroaryl halides with phenylboronic acid, to gave the Ph heteroaryl II [Ar³ = 3-pyridyl, 5-pyrimidinyl, 3-quinolyl, etc.] in good to excellent yields. A test reaction on gram scale delivered the product in reasonably high yield and thus had the potential of promising applications in drug discovery and functional materials.

Application of C9H6BrN, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. Application of C9H6BrN.

Theeramunkong, Sewan;Thiengsusuk, Artitiya;Vajragupta, Opa;Muhamad, Phunuch research published 《 Synthesis, characterization and antimalarial activity of isoquinoline derivatives》, the research content is summarized as follows. Abstract: This paper presents synthesis of novel decorated isoquinolines that can be used as antimalarial agents. Two series of compounds, isoquinoline Ph and isoquinoline triazole derivatives, were synthesized via the Suzuki-Miyaura and Sharpless-Fokin reactions resp. The final compounds were investigated for their antimalarial activity in cell-based experiments In the series of isoquinoline Ph derivatives, compound 6 exhibited interesting antiplasmodial activity against chloroquine resistant (K1) and chloroquine sensitive (3D7) strains of P. Falciparum with IC₅₀ 1.91 ± 0.21μM and 2.31 ± 0.33μM, resp. In the series of isoquinoline-triazole derivatives, compound 15 was the most active against resistant (K1) and sensitive (3D7) strains of P. falciparum with IC₅₀ 4.55 ± 0.10μM and 36.91 ± 2.83μM, resp. The resp. resistance indexes of compounds 6 and 15 against K1 and 3D7 were 0.83 and 0.12. Compound 15 was promisingly effective against the resistant strain. The results of this study provided useful contributions for further lead discovery and lead modification of modern rational drug design.

1532-97-4, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., Application of C9H6BrN

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Isoquinoline can crystallizes in platelets that have a low solubility in water but dissolve well in ethanol, acetone, diethyl ether, carbon disulfide, and other common organic solvents. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. It is also soluble in dilute acids as the protonated derivative. Safety of 4-Bromoisoquinoline.

Theeramunkong, Sewan;Maicheen, Chirattikan;Krongsil, Rinnara;Chaichanasap, Waritsara;Asasutjarit, Rathapon;Vajragupta, Opa research published 《 Synthesis and in vitro biological evaluation of (iso)quinoline-1,2,3-triazole derivatives as anticancer agents》, the research content is summarized as follows. Two series of triazole derivatives I [Ar = 1-naphthyl, pyridin-3-yl, isoquinolin-4-yl, etc.; R = 2-methoxyphenyl, 4-tert-butylphenyl, 2-cyanophenyl, etc.] were designed and synthesized as potential anticancer agents. A series of eighteen novel 1,2,3-triazole derivatives I were synthesized through copper catalyzed click reaction. The compounds were evaluated for their cytotoxicity activity against HepG2, HeLa cell and HEK293 cell lines using MTT assay. The results showed that compounds [Ar = 4-isoquinolyl; R = 2-methoxyphenyl, 3-cyanophenyl] were the most potent compounds against HepG2 cell with IC50 values 9.6 and 13.3μM, resp. Addnl., the compounds I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl, 3-cyanophenyl] were the most potent compounds against HeLa cell with IC50 values 5.7 and 5.8μM, resp. The results of tubulin polymerization assay demonstrated that lead compound I [Ar = 4-isoquinolyl; R = tert-butyl] and compound I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] could inhibit in vitro tubulin polymerization In addition, a mechanism study displayed that I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] blocked cell cycle arrest at G2/M phase. Furthermore, a mol. docking study demonstrated that I [Ar = 4-isoquinolyl; R = 2-methoxyphenyl] could bind to the colchicine site of tubulin and form hydrogen bonds in the active site of β-tubulin. In summary, this study recommended a promising isoquinoline-triazole scaffold for further development as more efficient microtubule polymerization inhibitors in the field of cancer treatment.

Safety of 4-Bromoisoquinoline, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. Related Products of 1532-97-4.

Tang, Shuang-Qi;Schmitt, Martine;Bihel, Frederic research published 《 POxAP Precatalysts and the Negishi Cross-Coupling Reaction》, the research content is summarized as follows. Recently developed for the Fukuyama reaction, post-oxidative addition precatalysts (POxAPs) were also very efficient in catalyzing Negishi cross-coupling reactions between organohalides and organozinc reagents. Using very low catalyst loadings, POxAPs showed similar catalytic activities to those of classical precatalysts such as XPhos Pd G4 or PEPPSI-IPr, with turnover numbers of up to 93,000. POxAPs were easily prepared, and stable to air and moisture, tolerate a wide range of functional groups in the Negishi cross-coupling reaction and contribute advantageously to the arsenal of organic chemists in terms of Pd precatalysts.

Related Products of 1532-97-4, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Isoquinoline can crystallizes in platelets that have a low solubility in water but dissolve well in ethanol, acetone, diethyl ether, carbon disulfide, and other common organic solvents. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. It is also soluble in dilute acids as the protonated derivative. Synthetic Route of 1532-97-4.

Sun, Yunlong;Li, Tian research published 《 Fabrication and Application of Graphene Supported Diimine-Palladium Complex Catalyst for Organic Synthesis》, the research content is summarized as follows. In this paper, a diimine palladium complex with suitable steric hindrance of iso-Pr groups and electron supply provided excellent protection for palladium active centers was synthesized and anchored on graphene oxide (GO) to obtain a reusable heterogeneous catalyst (Pd-DI@GO). The XPS results confirmed the effective loading of palladium and the interaction between palladium and ligand. The ICP-AES data verified the Pd content of catalyst was 5.04 wt% and confirmed extremely small amount Pd leaching in Suzuki reaction (<1 ppm). The Pd-DI@GO could catalyze Suzuki reaction and C-H direct arylation reaction of aryl bromides and arylboronic acids/heterocycles to afford biaryls R-R¹ [R = Ph, 4-MeC₆H₄, 2-MeOC₆H₄, etc.; R¹ = Ph, 1-naphthyl, 2-pyridyl, etc] and R²-R³ [R² = Ph, 4-ClC₆H₄, 4-tBuC₆H₄, etc. R³ = 2,4-(Me)₂-5-thiazolyl, 2-Me-5-thiazolyl, 4-Me-5-thiazolyl] with high yields. Notably, the Pd-DI@GO could be recycled after Suzuki reaction via filtration or centrifugation easily, presented a yield above 90% for the 4^th run.

1532-97-4, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., Synthetic Route of 1532-97-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Isoquinoline’s properties: Isoquinoline is a colorless hygroscopic liquid at temperatures above its melting point with a penetrating, 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. unpleasant odor. Impure samples can appear brownish, as is typical for nitrogen heterocycles. Safety of 4-Bromoisoquinoline.

Stepanova, Victoria A.;Patrushev, Sergey S.;Rybalova, Tatyana V.;Shults, Elvira E. research published 《 Cross-coupling reaction to access a library of eudesmane-type methylene lactones with quinoline or isoquinoline substituent》, the research content is summarized as follows. An efficient and simple protocol for the Heck reaction of accessible natural eudesmane-type methylene lactone isoalantolactone or its derivatives – 4,15-epoxyisoalantolactone, and 3-hydroxyisoalantolactone, with halo-substituted quinolines and isoquinolines using Pd(OAc)₂ as the catalyst is presented. The reactions proceed well in DMF and TBAB in the absence of phosphine ligands. The structures of isoalantolactone-quinoline and isoalantolactone-isoquinoline hybrids were analyzed by mass spectrum, elemental anal. and NMR spectral studies. The crystal structure of new compounds was determined from single crystal X-ray diffraction data.

Safety of 4-Bromoisoquinoline, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Isoquinoline can crystallizes in platelets that have a low solubility in water but dissolve well in ethanol, acetone, diethyl ether, carbon disulfide, and other common organic solvents. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. It is also soluble in dilute acids as the protonated derivative. Related Products of 1532-97-4.

Stambirskyi, Maksym V.;Kostiuk, Tetiana;Sirobaba, Serhii I.;Rudnichenko, Alexander;Titikaiev, Dmytro L.;Dmytriv, Yurii V.;Kuznietsova, Halyna;Pishel, Iryna;Borysko, Petro;Mykhailiuk, Pavel K. research published 《 Phosphine Oxides (-POMe₂) for Medicinal Chemistry: Synthesis, Properties, and Applications》, the research content is summarized as follows. A general practical approach to hetero(aromatic) and aliphatic P(O)Me₂-substituted derivatives is elaborated. The key synthetic step was a [Pd]-mediated C-P coupling of (hetero)aryl bromides/iodides with HP(O)Me₂. The P(O)Me₂ substituent was shown to dramatically increase solubility and decrease lipophilicity of organic compounds This tactic was used to improve the solubility of the antihypertensive drug prazosin without affecting its biol. profile.

1532-97-4, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., Related Products of 1532-97-4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

In a broader sense, the term isoquinoline is used to make reference to isoquinoline derivatives. 1-Benzylisoquinoline is the structural backbone in naturally occurring alkaloids including papaverine. 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. The isoquinoline ring in these natural compound derives from the aromatic amino acid tyrosine. Safety of 4-Bromoisoquinoline.

Song, Wenyue;Rao, Xiaofeng;Bu, Qingqing;Liu, Ning research published 《 Carbazole-bridged NCN-pincer palladium complex catalyzed direct C-H arylation reaction of azoles》, the research content is summarized as follows. A new type of pincer palladium complexes C1∼C6 based on the strong donor strength of carbazoles skeleton were synthesized. The air- and moisture-stable complexes C1∼C6 act as efficient catalysts for the direct arylation of azoles with (hetero)aryl bromides in good to excellent yields with broad substrate scope used KOAc as sole base under aerobic conditions. It was demonstrated that this developed protocol was used as catalytic system for the direct C-H bond arylation of thiazoles under relatively mild reaction conditions at a low catalyst loading of 0.5 mol%.

Safety of 4-Bromoisoquinoline, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., 1532-97-4.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Isoquinoline’s properties: Isoquinoline is a colorless hygroscopic liquid at temperatures above its melting point with a penetrating, 1532-97-4, formula is C9H6BrN, Name is 4-Bromoisoquinoline. unpleasant odor. Impure samples can appear brownish, as is typical for nitrogen heterocycles. Category: isoquinoline.

Song, A-Xiang;Zeng, Xiao-Xiao;Ma, Bei-Bei;Xu, Chang;Liu, Feng-Shou research published 《 Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions》, the research content is summarized as follows. With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsym. Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The use of this unsym. strategy led to much higher efficiency in comparison to the commonly used C₂-sym. Pd-PEPPSI-type NHC complexes. Also, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at ≥0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with the authors’ study, also the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

1532-97-4, 4-Bromoisoquinoline, also known as 4-Bromoisoquinoline, is a useful research compound. Its molecular formula is C9H6BrN and its molecular weight is 208.05 g/mol. The purity is usually 95%.

4-Bromoisoquinoline is an aryl halide that can be used in the cross-coupling reaction with other aryl halides. It has been shown to have anticancer activity and to inhibit the growth of tumour cell lines in vitro. This compound is also efficient for inhibiting leukemia cells. 4-Bromoisoquinoline has been shown to have an inhibitory effect on cancer cells through the inhibition of DNA synthesis and RNA transcription, as well as by inducing apoptosis. The mechanism of action may be due to its ability to bind to aromatic hydrocarbons and halides, which leads to thermodynamic changes and vibrational energy transfer., Category: isoquinoline

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem