Heterocyclic Building Blocks-Isoquinoline

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-04-8,5-Bromoisoquinoline,as a common compound, the synthetic route is as follows.

Synthesis of 5-bromo-8-nitroisoquinoline Into a 500 mL 3-necked round-bottom flask, was placed a solution of 5-bromoisoquinoline (22.24 g, 106.87 mmol) in H2SO4 (120 mL). This was followed by the addition of a solution of KNO3 (15.1 g, 149.36 mmol) in H2SO4 (100 mL), which was added dropwise with stirring, while cooling to a temperature of 20 C. over a time period of 1 h. The resulting solution was allowed to react, with stirring, for 1 h while the temperature was maintained at room temperature. The reaction progress was monitored by TLC (EtOAc/PE 1:5). The reaction mixture was then quenched by the adding 600 mL of H2O/ice-Adjustment of the pH to 8-10 was accomplished by the addition of NH3.H2O (30%). A filtration was performed. The filter cake was washed 2 times with 500 mL of H2O. The solid was dried in an oven under reduced pressure. This resulted in 25.59 g (90%) of 5-bromo-8-nitroisoquinoline as a yellow solid.

34784-04-8, 34784-04-8 5-Bromoisoquinoline 736487, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; US2008/318941; (2008); A1;,
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Isoquinoline | C9H7N – PubChem

1109230-25-2, 5-Bromo-3,4-dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

5-bromo-3,4-dihydroisoquinoline-1(2H)-one (1.05 g, 4.64 mmol) was dissolved in concentrated sulfuric acid in a 50 mL single-mouth bottle(15mL), at -10C,KNO3 (1.04 g, 7.00 mmol) was slowly added, the solution was pale yellow and stirred for 1.0 h. After warming to room temperature, the reaction was continued for 3.0 h.The reaction was monitored by TLC, poured into ice water and extracted with EA (15 mL¡Á3).Dry over anhydrous sodium sulfate,Concentrate, silica gel column chromatography, rinse with PE/EA=20/1-10/1,Obtained white solid 0.42g, yield 33%,, 1109230-25-2

The synthetic route of 1109230-25-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Lin Xinglong; Xie Hongming; Hu Yangxiao; Li Shiguang; Zhang Yingjun; Tan Yumei; Yuan Mingyun; (124 pag.)CN108948019; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

90.0 mg of (1S)-N’,N’-dimethyl-1-phenyl-ethane-1,2-diamine (550 mumol) was dissolved in 10.0 mL of DMF, to which 153 mg of HBTU (600 mumol), 105 mg of 6-isoquinolinecarboxylic acid (600 mumol) and 284 g of N, N-diisopropyl ethylamine (2.19 mmol) were added. The reaction mixture was stirred for 1 h and extracted with ethyl acetate and water. Then the aqueous phase was extracted twice with ethyl acetate, and the organic phases were combined, dried with anhydrous sodium sulfate, desolventized under vacuum and purified by column chromatography to give 52 mg of benzyl-N-((2S)-2-(isoquinoline-6-formamide)-2-phenyl-ethyl) carbamate (0.13 mmol) with a yield of 24%., 106778-43-2

The synthetic route of 106778-43-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Hitgen Ltd.; LI, Jin; ZHANG, Dengyou; FENG, Jingchao; LIAO, Wei; LIN, Li; LI, Si; CHEN, Wei; (41 pag.)EP3640242; (2020); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

119-65-3, Isoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

lntermediate-12: 3-Bromoisoquinoline: To a stirred solution of isoquinoline (24 g, 186 mmol) in AcOH (50 mL) was added NBS (36.2 g, 204.6 mmol) at RT and the reaction mixture was heated to 100 2C overnight. Then it was cooled to RT and concentrated under reduced pressure. The crude product obtained was purified by flash column chromatography (5% EtOAc:Hexanes) to furnish the title compound (9.2 g, 23.8%) as an oil., 119-65-3

As the paragraph descriping shows that 119-65-3 is playing an increasingly important role.

Reference£º
Patent; LUPIN LIMITED; KULKARNI, Sanjeev, Anant; MADAN, Sachin; JANA, Nirmal, Kumar; TALE, Prashant, Vitthalrao; CHEEMALA, Narasimha, Murthy; MAHANGARE, Sachin, Jaysing; VIDHATE, Prashant, Popatrao; KULKARNI, Chaitanya, Prabhakar; PATEL, Sapana, Suresh; PATIL, Amolsing, Dattu; ZADE, Seema, Prabhakar; SHINDE, Rohan, Mahadev; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2013/5168; (2013); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52986-70-6,6-Methoxyisoquinoline,as a common compound, the synthetic route is as follows.

52986-70-6, General procedure: A flame-dried and nitrogen flushed 50 mL Schlenk flask, equipped with a magnetic stirringbar, was charged with the appropriate isoquinoline 7a-c (prepared according to lit. [1,2])(2.00 mmol) in dry THF (10 mL). TMPMgClLiCl (1.0 M in THF/toluene; 3.00 mL, 3.00 mmol)was added to this solution dropwise over 2 min. The reaction mixture was stirred at roomtemperature for 4 h. After cooling to 0 C, a solution of iodine (0.761 g, 3.00 mmol) in dryTHF (3 mL) was added dropwise to the reaction mixture. The cooling bath was removed andthe mixture was stirred at room temperature for 1 h. Then the mixture was quenched withsatd. aqueous NH4Cl solution (4 mL) and satd. aqueous Na2S2O3 solution (4 mL). Afterextraction with dichloromethane (3 ¡Á 20 mL), the combined organic layers were dried withNa2SO4, and concentrated under reduced pressure. The residue was purified by flashcolumn chromatography (ethyl acetate/dichloromethane = 1:5).

52986-70-6 6-Methoxyisoquinoline 11040978, aisoquinoline compound, is more and more widely used in various.

Reference£º
Article; Melzer, Benedikt C.; Bracher, Franz; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 1564 – 1571;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

34784-05-9, 6-Bromoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

[0187] 6-bromoisoquinoline (1.80g, 8.66 mmol) was dissolved in DCM (40 mL), after cooling down the reaction to 0C m-CPBA (2.30 g, 1.3 eq, 77% max) was added slowly in small portion. The reaction was warmed up to RT to become a kind of white suspension. In 4 hours, 1 OOmL DCM was added into the solution, and washed with saturated Na2C03 solution, water and brine. The separated organic layer was dried over Na2S04 and removed under the vacuum to get the yellow solid N-oxide 6-bromoisoquinoline without further purification (1.82 g, yield -93%).

34784-05-9, As the paragraph descriping shows that 34784-05-9 is playing an increasingly important role.

Reference£º
Patent; AN, Songzhu; CUREGENIX, INC.; WO2014/159733; (2014); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80278-67-7,Isoquinoline-5-carbaldehyde,as a common compound, the synthetic route is as follows.

General procedure: To a dried two-neck round-bottom flask containing DMF (0.7mL for 1.10mmol of starting material) chilled in an ice bath, POCl3 (1.95 equiv) was added slowly. After stirring for 20min, a solution of an indole derivative (1.0 equiv) in DMF (3mL for 1.10mmol of starting material) was added dropwise. The reaction was allowed to warm to room temperature and allowed to stir for 1.5h. The reaction was quenched by adding ice followed by 1N NaOH (40mL) dropwise in an ice bath. The crude mixture was allowed to stand at room temperature and the precipitate formed was filtered to afford the 3-formyl-indole derivative product., 80278-67-7

The synthetic route of 80278-67-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; See, Cheng Shang; Kitagawa, Mayumi; Liao, Pei-Ju; Lee, Kyung Hee; Wong, Jasmine; Lee, Sang Hyun; Dymock, Brian W.; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 344 – 367;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

66491-03-0,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.66491-03-0,7-Amino-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

Intermediate 16 (400mg) was dissolved with 10ml of acetone, was added trimethylsilyl cyanide (2ml) and acetic acid 2ml, sealed tube, heated to 60 deg.] C overnight.The reaction was cooled to room temperature, concentrated under reduced pressure after adding water, an aqueous solution (100ml ¡Á 3) and extracted with ethyl acetate, the ethyl acetate layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, filtered and concentrated to dryness to give a yellow oil It was flash column chromatography (petroleum ether: ethyl acetate = 2: 1) to give the intermediate 17 (460mg).

The synthetic route of 66491-03-0 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences,; Duan, WenHu; Wan, huixin; Xia, GuangXin; Mei, deCheng; Lin, Yipeng; Liu, Xuejun; Shen, JingKang; (53 pag.)CN103804358; (2016); B;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6624-49-3, The compound 3-isoquinolinecarboxylic acid (0801-132) (1.0 g, 5.78 mmol, 1.0 eq.)Dissolved in 30 ml of methanol,Sulfuric acid (0.5 ml) was then added and the reaction was refluxed overnight.After the reaction is finished, add sodium bicarbonate solutionpH to 8, extracted with dichloromethane, liquid-separated, and the organic phase dried over anhydrous sodium sulfate.Spin-drying afforded the compound 3-isoquinolinecarboxylic acid methyl ester (810 mg, 75percent).

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Patent; Guangzhou Bi Beite Pharmaceutical Co., Ltd.; Cai Xiong; Qian Changgeng; Weng Yunwo; Qing Yuanhui; Liu Bin; Lin Mingsheng; Wang Yanyan; (126 pag.)CN107383024; (2017); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.164148-92-9,tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate,as a common compound, the synthetic route is as follows.

Step-3: Synthesis of tert-butyl 6-((2-cyclopropyl-1-(6-(2-fluoropropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate To a stirred solution of 1-(6-(tert-butyl)pyridin-2-yl)-2-cyclopropyl-6-(methylthio)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one (260 mg, 0.722 mmol, 1.0 eq) in (5.0 mL) of toluene was added m-CPBA (249 mg, 1.444 mmol, 2.0 eq) and allowed to stir at rt for 30 minutes. tert-butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate (358 mg, 1.444 mmol, 2.0 eq) and DIPEA (0.5 mL, 2.888 mmol, 4.0 eq) were added and allowed to stir at rt for overnight. After completion of reaction, the reaction mixture was diluted with water and extracted with EtOAc (50 mL*2). The combined organic layer was washed with water (50 mL), brine solution (50 mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford crude product, which was purified by flash chromatography [silica gel 100-200 mesh; elution 0-50% EtOAc in hexane] to afford the desired compound, tert-butyl 6-((2-cyclopropyl-1-(6-(2-fluoropropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3,4-dihydroisoquinoline-2(1H)-carboxylate (100 mg, 24.75%) as an off white solid.

164148-92-9, 164148-92-9 tert-Butyl 6-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate 2756371, aisoquinoline compound, is more and more widely used in various.

Reference£º
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; Gupta, Ashu; KUMAR, Varun; (498 pag.)US2019/106427; (2019); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem