Tag: M.W=100-150

Yasukawa, Naoki published the artcileGold-Catalyzed Tandem Oxidative Coupling Reaction between β-Ketoallenes and Electron-Rich Arenes to 2-Furylmethylarenes, Product Details of C8H10O2, the main research area is furylmethylarene preparation; ketoallene arene tandem oxidative coupling reaction gold catalyst.

A tandem oxidative coupling reaction of β-ketoallenes R1C(O)CH(R2)CH=C=CH2 (R1 = Ph, n-nonyl, 2-methoxyphenyl, etc.; R2 = H, n-pentyl; R1R2 = -(CH2)4-) and arenes ArH (Ar = 2,4,6-triemthoxyphenyl, 1H-indol-3-yl, 2-methoxy-9-methyl-9H-carbazol-3-yl, etc.) was developed, which leads to the formation of 2-furylmethylarenes I using AuCl3 and phenyliodine diacetate. The AuIII salt catalyzed the cyclization of β-ketoallenes to form a 2-furylmethyl gold intermediate, and the subsequent C-H functionalization of arenes proceeded smoothly. During the oxidative coupling, nucleophilic additions occurred at the center and terminal carbon atoms of the allene moiety to form C-O and C-C bonds.

Organic Letters published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent) (keto). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Guangkuan published the artcileA Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters, Synthetic Route of 151-10-0, the main research area is chloroaminal arene Friedel Crafts alkylation amino ester regioselective preparation.

A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/Bronsted acid pair mechanism, we also report a catalytic enantioselective example of the reaction.

Organic Letters published new progress about Aminals Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Luo, Zhenli published the artcileBF3·Et2O as a metal-free catalyst for direct reductive amination of aldehydes with amines using formic acid as a reductant, Application of 4-Methoxy-N-methylaniline, the main research area is aldehyde amine reductive amination formic acid reductant boron trifluoride.

A versatile metal- and base-free direct reductive amination of aldehydes with amines using formic acid as a reductant under the catalysis of inexpensive BF3·Et2O has been developed. A wide range of primary and secondary amines and diversely substituted aldehydes are compatible with this transformation, allowing facile access to various secondary and tertiary amines in high yields with wide functional group tolerance. Moreover, the method is convenient for the late-stage functionalization of bioactive compounds and preparation of commercialized drug mols. and biol. relevant N-heterocycles. The procedure has the advantages of simple operation and workup and easy scale-up, and does not require dry conditions, an inert atm. or a water scavenger. Mechanistic studies reveal the involvement of imine activation by BF3 and hydride transfer from formic acid.

Green Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cho, Jin Hee published the artcileA bimetallic PdCu-Fe3O4 catalyst with an optimal d-band centre for selective N-methylation of aromatic amines with methanol, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is amine methanol methylation; bimetallic palladium copper iron oxide nanoparticle catalyst preparation.

Catalytic methylation utilizing methanol as a sustainable C1 building block and hydrogen source continues to attract attention due to its atom-economical, cost-effective, and simple one-pot method. So far, research on heterogeneous systems has been limited to noble monometallic catalysts such as Ir, Pd, and Pt. A bimetallic catalyst containing a non-noble metal can be an ideal tool to modulate the reactivity and economic feasibility. Reported herein is a bimetallic PdCu-Fe3O4 nanoparticle (NP) catalyst for the selective N-methylation of aniline with methanol as a carbon source in the presence of K2CO3 via a “”hydrogen-borrowing strategy””. The PdCu alloy showed synergistic catalytic activity, superior to monometallic Pd and Cu catalysts. The best catalytic activity for N-methylation of aniline was achieved when the Pd/Cu metal ratio was 1:0.6 and on an Fe3O4 support. To explain the details of the synergistic effect according to the metal composition, authors investigated the electronic properties of the catalytic surface of PdxCuy on Fe3O4 NPs through the d. functional theory (DFT). DFT calculation and kinetic studies successfully delineated the catalytic activities of N-methylation depending on varying Pd/Cu ratios. Highly efficient monomethylation of a wide range of aromatic amines was possible using the optimally chosen Pd1Cu0.6 catalyst. Furthermore, the catalyst could be recycled and reused owing to the magnetic nature of the Fe3O4 support.

Catalysis Science & Technology published new progress about Aromatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

China, Hideyasu published the artcileRegiodivergent oxidation of alkoxyarenes by hypervalent iodine/oxone system, Application In Synthesis of 151-10-0, the main research area is monomethoxyarene iodobenzoic acid oxone regioselective oxidation green chem.

The combination of Oxone with an organoiodine compound, i.e., 2-iodobenzoic acid (2-IB), selectively yields p-quinones from monomethoxyarenes under mild conditions was reported. In this reaction system, an organoiodine compound was immediately oxidized by Oxone to generate cyclic hypervalent iodine (III) species in-situ, which served as the specific mediator for the selective p-quinone synthesis, preventing o-quinone formation.

Catalysis Today published new progress about Aromatic ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ambre, Ram published the artcileNickel Carbodicarbene Catalyzed Kumada Cross-Coupling of Aryl Ethers with Grignard Reagents through C-O Bond Activation, Application of 1,3-Dimethoxybenzene, the main research area is biaryl compound preparation; aryl ether Grignard reagent Kumada cross coupling carbodicarbene nickel.

The development of a cross-coupling reaction protocol between aryl ethers and Grignard reagents catalyzed by carbodicarbene (CDC) nickel complexes to afford biaryl compounds through C-O cleavage is reported. Aromatic substrates featuring a broad range of electron neutral, donating, or withdrawing groups are introduced at the desired position. The method has proven effective over a wide range of naphthyl Me ethers, anisoles, and Grignard reagents. The robustness of the protocol is validated by performing multiple cleavage reactions, gram scale synthesis, and arylation of a dimethoxy esterdiol derivative

European Journal of Inorganic Chemistry published new progress about Aromatic ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Xiao-Ya published the artcileDesign of Lewis base functionalized ionic liquids for the N-formylation of amines with CO2 and hydrosilane: The cation effects, Synthetic Route of 5961-59-1, the main research area is recyclable ionic liquid preparation; amine carbon dioxide hydrosilane ionic liquid formylation green chem; formamide preparation.

A series of functionalized ionic liquids (ILs) were developed for the reductive functionalization of CO2 with amine and hydrosilane to afford formamides under mild conditions. It was found that 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-based IL i.e. [DBUC12]Br showed high efficiency for the N-formylation reaction of amines without using any organic solvents or additives. Furthermore, control experiments suggested the cations with active hydrogen may weaken the nucleophilicity of anions through ion pairing interactions, thereby affecting the activation of hydrosilane. The reaction mechanism was then investigated by D. Functional Theory (DFT) calculations This protocol represented a highly efficient and environmentally friendly example for catalytic conversion of CO2 into value-added chems. such as formamide derivatives by employing DBU functionalized ILs.

Catalysis Today published new progress about Formamides Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

He, Xinxin published the artcileBis-selenonium Cations as Bidentate Chalcogen Bond Donors in Catalysis, SDS of cas: 151-10-0, the main research area is bis selenium cation catalyst preparation Lewis acid; imine diene selenium catalyst aza Diels Alder reaction; dienophile diene selenium catalyst Diels Alder reaction; arene selenium catalyst bromination.

Hydrolytically stable bidentate Lewis acid catalysts derived from selenonium dicationic centers were developed. The bis-selenonium catalysts were employed in the activation of imine and carbonyl groups in various transformations with good yields and selectivity. Lewis acidity of the bis-selenonium salts was found to be stronger than that of the monoselenonium systems, attributed to the synergistic effect of the two cationic selenonium centers. In addition, the bis-selenonium catalysts were not inhibited by strong bases or moisture.

ACS Catalysis published new progress about 1,3-Alkadienes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kang, Zhenghui published the artcilePrivilege-Structure-Oriented Three-Component Asymmetric Aminomethylation: Assembly of Chiral 3-Aminomethyl Indolones, Computed Properties of 151-10-0, the main research area is diazooxindole arene acetal dirhodium phosphoric acid chiral aminomethylation catalyst; indolone aminomethyl stereoselective preparation.

The asym. aminomethylation reaction of 3-diazooxindoles with electronic-rich arenes and N,O-acetals cooperatively catalyzed by achiral dirhodium complex and chiral phosphoric acid is reported. The reaction provides a novel method for the facile synthesis of chiral 3-aminomethyl oxindoles with an all-carbon quaternary center in good yields (82-98%) with high to excellent enantioselectivities (up to 97% ee). The transformation proceeds through a convergent addition of a reactive zwitterionic intermediate with a chiral methylene iminium generated in situ via asym. counteranion-directed catalysis (ACDC). This work represents the first asym. aminomethylation method of mixed 3,3′-bisindoles with structural diversity.

Organic Letters published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent) (N,O-). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Jian-Qiang published the artcileEfficient access to aliphatic esters by photocatalyzed alkoxycarbonylation of alkenes with alkyloxalyl chlorides, Application of 4-Methoxy-N-methylaniline, the main research area is ester preparation; alkene alkyloxalyl chloride alkoxycarbonylation photocatalyst.

A strategy to access aliphatic esters RC(O)OR1 (R = 2-chloro-2-(4-methylphenyl)ethyl, 2-chloroheptyl, 2-chloro-2-cyclohexylethyl, 2-chloro-3-(2,3-dihydro-1H-indol-1-yl)-2-methyl-3-oxopropyl, etc.; R1 = Et, 1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl, 4-phenylbutyl, etc.) from olefins RH through a photocatalyzed alkoxycarbonylation reaction was reported. Alkyloxalyl chlorides R1C(O)2C(O)Cl, generated in situ from the corresponding alcs. R1OH and oxalyl chloride, are engaged as alkoxycarbonyl radical fragments under photoredox catalysis. This transformation tolerates a broad scope of electron-rich and electron-deficient olefins and provides the corresponding β-chloro esters in good yields. Addnl., a formal β-selective alkene alkoxycarbonylation is developed. Moreover, a variety of oxindole-3-acetates I (R2 = H, t-Bu, CN, me, etc.; R3 = Me, Bn; R4 = Me, Et, Bn, i-Pr), Et 2-(1-methyl-2-oxo-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)acetate, Et 2-(7-methyl-6-oxo-1,2,3,4,6,7-hexahydroazepino[3,2,1-hi]indol-7-yl)acetate, Et 2-(1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[g]indol-3-yl)acetate and furoindolines II are prepared in good to excellent yields. A more concise formal synthesis of (±)-physovenine is accomplished as well. With these strategies, a wide range of natural-product-derived olefins and alkyloxalyl chlorides are also successfully employed.

Nature Communications published new progress about Acid chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Application of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem