Zhao, Guangkuan published the artcileA Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters, Synthetic Route of 151-10-0, the main research area is chloroaminal arene Friedel Crafts alkylation amino ester regioselective preparation.
A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/Bronsted acid pair mechanism, we also report a catalytic enantioselective example of the reaction.
Organic Letters published new progress about Aminals Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 151-10-0.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem