Tag: M.W=100-150

Xu, Yingzhou published the artcileRegioselective bromination of arenes mediated by triphosgene-oxidized bromide, Name: 1,3-Dimethoxybenzene, the main research area is bromoarene preparation regioselective; arene bromination triphosgene oxidized bromide mediated.

This article first time described triphosgene (BTC) as an oxidant while the non-toxic and easy-to-handle potassium bromide (KBr) as the source of bromine for the bromination reaction of aromatic substrates to afford bromoarenes. The novel brominating protocol gave excellent para-regioselectivity of the alkoxyl/hydroxyl arenes and high yield, offering good potential of com. scale applications. The mechanism of “”triphosgene oxidize bromide”” was proposed.

Tetrahedron published new progress about Aryl bromides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bomon, Jeroen published the artcileEfficient demethylation of aromatic methyl ethers with HCl in water, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is alc aryl preparation green chem; aryl methyl ether demethylation hydrochloric acid catalyst.

A green, efficient and cheap demethylation reaction of aromatic Me ethers, e.g., 2H-1,3-benzodioxole-5-carbaldehyde with mineral acid (HCl or H2SO4) as a catalyst in high temperature pressurized water provided the corresponding aromatic alcs.e.g., 3,4-dihydroxybenzaldehyde in high yield. 4-Propylguaiacol was chosen as a model, given the various applications of the 4-propylcatechol reaction product. This demethylation reaction could be easily scaled and biorenewable 4-propylguaiacol from wood and clove oil could also be applied as a feedstock. Greenness of the developed method vs. state-of-the-art demethylation reactions was assessed by performing a quant. and qual. Green Metrics anal. Versatility of the method was shown on a variety of aromatic Me ethers containing (biorenewable) substrates, yielding up to 99% of the corresponding aromatic alcs., in most cases just requiring simple extraction as work-up.

Green Chemistry published new progress about Alkyl aryl ethers Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lui, Yuen Wai published the artcileMethylation with Dimethyl Carbonate/Dimethyl Sulfide Mixtures: An Integrated Process without Addition of Acid/Base and Formation of Residual Salts, HPLC of Formula: 151-10-0, the main research area is methylphenol preparation; methylbenzoate preparation; phenylpropanenitrile preparation; alkylation; dimethyl carbonate; green solvent; lignin; organocatalysis.

Di-Me sulfide, a major byproduct of the Kraft pulping process, was used as an inexpensive and sustainable catalyst/co-reagent (Me donor) for various methylations with di-Me carbonate (as both reagent and solvent), which afforded excellent yields of O-methylated phenols and benzoic acids, and mono-C-methylated arylacetonitriles. Furthermore, these products could be isolated using a remarkably straightforward workup and purification procedure, realized by di-Me sulfide’s neutral and distillable nature and the absence of residual salts. The likely mechanisms of these methylations were elucidated using exptl. and theor. methods, which revealed that the key step involves the generation of a highly reactive trimethylsulfonium methylcarbonate intermediate. The phenol methylation process represents a rare example of a Williamson-type reaction that occurs without the addition of a Bronsted base.

ChemSusChem published new progress about Alkylphenols Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shang, Yaping published the artcileRhodium(III)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is alkyl indole preparation; internal alkyne aniline transient oxidizing directing group rhodium catalyst.

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compds I (R1 = Me, allyl, C6H5, etc.; R2 = 5-Me, 6-CH2OMe, 5-NO2, etc.) and II (R1 = Me, Et, i-Pr, etc.; R2 = H, 5-Me, 5-CO2Me, etc.; R3 = n-Bu, C6H5, 4-MeC6H5, etc.; R4 = Me, COMe, 3-FC6H5, etc.). This work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkynes, internal Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jud, Wolfgang published the artcileElectrochemical α-Arylation of Ketones via Anodic Oxidation of in situ Generated Silyl Enol Ethers, Name: 1,3-Dimethoxybenzene, the main research area is aryl ketone electrochem arylation arene; aralkyl ketone preparation.

An electrochem. procedure for the α-arylation of ketones has been developed. The method is based on the generation and one-pot anodic oxidation of silyl enol ethers in the presence of an arene. This strategy avoids isolation of the silyl enol intermediate and the utilization of external supporting electrolytes. Intermol. arylations, which had not been reported so far, are possible when electron-rich arenes are utilized as coupling partners. The method has been demonstrated for a wide variety of aryl ketones and activated arenes in moderate to good yields (up to 69%). Mechanistic insights and a theor. rationale that explained the ketone α-arylation vs. dimerization selectivity are also presented.

Journal of Organic Chemistry published new progress about Aralkyl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pradhan, Suman published the artcileRegiodivergent Aromatic Electrophilic Substitution Using Nitrosoarenes in Hexafluoroisopropanol: A Gateway for Diarylamines and p-Iminoquinones Synthesis, Application of 1,3-Dimethoxybenzene, the main research area is diaryl amine iminoquinone regiodivergent preparation; arene nitrosoarene regiodivergent aromatic electrophilic substitution.

A metal-free aromatic electrophilic substitution reaction using nitrosoarenes as electrophiles in 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) was reported. HFIP activates nitrosoarene toward the electrophilic C-H amination followed by a concomitant N-O bond cleavage to deliver diarylamines, e.g. I (R1 = H, Cl, I, CF3, R2 = H; R1 = H, R2 = Br, Me, EtO2C) from 1,3,5-trimethoxybenzene, without requiring any extra reagent or further treatment. The dual electrophilic nature of nitrosoarene permitted a switch-over of selectivity to C-H oxygenation furnishing dearomatized p-iminoquinones, such as II, following a unique mechanistic rationale of two consecutive [2,3] sigmatropic rearrangement in nitroso-chem.

Advanced Synthesis & Catalysis published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pandey, Vipin K. published the artcileSimple silver(I)-salt catalyzed selective hydroboration of isocyanates, pyridines, and quinolines, SDS of cas: 5961-59-1, the main research area is hydroboration isocyanate pyridine quinoline preparation formamide amine dihydropyridine tetrahydroquinoline; silver hexafluoroantimonate catalyst hydroboration reduction isocyanate pyridine quinoline.

AgSbF6 has been established as an effective catalyst for the hydroboration of structurally and electronically diverse isocyanates under ligand- and solvent-free conditions which selectively yielded either N-boryl formamides or N-boryl methylamines under different conditions. Further, various N-heterocycles can be selectively hydroborated using this simple catalytic system; pyridine derivatives undergo preferential 1,4 hydroboration whereas the formation of tetrahydroquinoline (after hydrolysis) via complete heterocycle hydrogenation was observed for quinolines.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bonnefoy, Clemence published the artcileStudy of Carbamoyl Fluoride: Synthesis, Properties and Applications, Category: isoquinoline, the main research area is carbamoyl fluoride preparation stability; amine fluorocarbonylation dinitrotrifluoromethoxybenzene; radiolabeled carbamoyl fluoride preparation; carbamoyl fluorides; dinitrotrifluoromethoxybenzene; fluorine; radiochemistry; trifluoromethoxide.

In this study, the little-explored carbamoyl fluorides have been studied in order to bring relevant information for their application to the community of chemists. A new easy, safe, inexpensive, and metal-free synthesis method is also described. Finally, a potential use in radiochem. through a 18F/19F isotopic exchange is demonstrated.

Chemistry – A European Journal published new progress about Acid fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cabrera-Lobera, Natalia published the artcileBronsted acid-catalyzed synthesis of tetrasubstituted allenes and polysubstituted 2H-chromenes from tertiary propargylic alcohols, COA of Formula: C8H10O2, the main research area is allene preparation tertiary propargylic alc allyl trimethylsilane; chromene preparation tertiary propargylic alc methoxyarene.

A practical and environmentally benign Bronsted acid-catalyzed protocol for the preparation of all-carbon tetrasubstituted allenes, consisting in the direct SN’ addition of tri- or dimethoxy arenes or allyltrimethylsilane to tertiary propargylic alcs., has been developed. In addition, a straightforward synthesis of densely substituted 2H-chromenes by metal-free tandem allenylation/heterocyclization reaction of methoxyphenols and tertiary alkynols is presented.

Tetrahedron published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kalita, Gitumoni published the artcilePara-Toluenesulfonic Acid Catalyzed Synthesis of Indenes a Tandem Friedel-Crafts Alkylation/Hydroarylation of Tertiary Propargylic Alcohols with Electron-Rich Arenes, HPLC of Formula: 151-10-0, the main research area is aryl phenylpropynol arene acid tandem Friedel Crafts alkylation hydroarylation; diaryl indene preparation regioselective.

A simple protocol to synthesize indenes efficiently by PTSA catalyzed tandem Friedel-Crafts alkylation/hydroarylation of tertiary propargylic alc. with electron-rich arenes was described. The desired indenes were obtained regioselectively in good to very good yields under mild reaction conditions. The allene intermediate was isolated to get an insight into the mechanistic pathway of the indene forming reaction.

Catalysis Letters published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem