Tag: M.W=100-150

Lu, Shang-Yuan published the artcilePyridinylidenaminophosphines as Versatile Organocatalysts for CO2 Transformations into Value-Added Chemicals, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is cyclic carbonate formyl amine preparation pyridinylidenaminophosphine catalyst.

The carboxylative cyclization of propargylic alcs. with CO2 was developed employing pyridinylidenaminophosphines (PYA-Ps) as organocatalyts for the first time. Moderate to good yields of α-methylene cyclic carbonates were obtained with excellent chemo- and stereo-selectivity. D. functional theory (DFT) calculations reveal that the catalytic reaction tends to proceed via the pyridinylidenaminophosphines-mediated basic ionic pair mechanism, and the intramol. cyclization should be the rate determining step. Furthermore, the catalytic diversity of PYA-Ps was investigated for the chem. transformations of CO2 to functionalized cyclic carbonates and N-formylated amines.

Asian Journal of Organic Chemistry published new progress about Alcohols, propargyl Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lux, Marcel published the artcileAdditions of Aldehyde-Derived Radicals and Nucleophilic N-Alkylindoles to Styrenes by Photoredox Catalysis, Product Details of C8H10O2, the main research area is photoredox catalyzed addition acyl radical alkylindole nucleophile styrene.

The consecutive addition of acyl radicals and N-alkylindole nucleophiles to styrenes was established, as well as some addnl. radical-nucleophile combinations. Both aryl and aliphatic aldehydes give reasonable yields. The reaction proceeds best for α-substituted styrenes, effectively creating a quaternary all-carbon center. Some iridium-based photoredox systems are catalytically active; furthermore, a base is needed in this transformation. Radicals are formed by reductive perester cleavage and hydrogen atom transfer.

Organic Letters published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Smith, Jordan N. published the artcileOne-Step Synthesis of C2v-Symmetric Resorcin[4]arene Tetraethers, Formula: C8H10O2, the main research area is tetraether resorcinarene preparation regioselective diastereoselective; alkyl aldehyde resorcinol dimethoxybenzene three component reaction.

The three-component reaction between a resorcinol, 1,3-dimethoxybenzene and alkyl aldehydes RCHO (R = Me, Et, iso-Pr, Bu, cyclohexyl, etc.) along with BF3.OEt2 affords a C2v-sym. resorcin[4]arene tetraethers I (R1 = H, Cl, Br, Me, OH; R2 = H, OH, Me, OMe) in one step; in most cases, the single isomer can be precipitated from the reaction mixture in moderate to excellent yields (up to 89%). The reaction is tolerant of 2-substituted resorcinols (R1 = OH, Cl, Br, Me), allowing a third type of functionality to be regioselectively incorporated during the macrocyclization.

Journal of Organic Chemistry published new progress about Aliphatic aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Krieg, Sara-Cathrin published the artcileOxyenamides as Versatile Building Blocks for a Highly Stereoselective One-Pot Synthesis of the 1,3-Diamino-2-ol-Scaffold Containing Three Continuous Stereocenters, COA of Formula: C8H10O2, the main research area is diamino alc diastereoselective one pot; oxyenamide preparation acylimine; 1,3-diamine; Lewis acid; enamides; one-pot reaction; stereoselective synthesis.

A highly diastereoselective one-pot synthesis of the 1,3-diamino-2-alc. unit bearing three continuous stereocenters is described. This method utilizes 2-oxyenamides as a novel type of building block for the rapid assembly of the 1,3-diamine scaffold containing an addnl. stereogenic oxygen functionality at the C2 position. A stereoselective preparation of the required (Z)-oxyenamides is reported as well.

Angewandte Chemie, International Edition published new progress about Amino alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Jiangjun published the artcileNickel-Catalyzed Intramolecular Desulfitative C-N Coupling: A Synthesis of Aromatic Amines, Product Details of C8H11NO, the main research area is aryl sulfonamide preparation nickel catalyst desulfonylative coupling; aromatic amine preparation.

A nickel-catalyzed intramol. C-N coupling reaction via SO2 extrusion was presented. The use of a catalytic amount of BPh3 allowed the transformation to take place under much milder conditions (60°C) than previously reported C-N coupling reactions by CO or CO2 extrusion (160-180°C). In addition, this method displayed good functional group tolerance and versatility, as it can be applied to the synthesis of dialkyl aryl amines, alkyl diaryl amines and triaryl amines. The robustness of the desulfitative C-N coupling was demonstrated by three high-yielding gram-scale reactions.

Journal of Organic Chemistry published new progress about Aminopyridines Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Fujita, Takeshi published the artcileAcid-mediated intermolecular C-F/C-H cross-coupling of 2-fluorobenzofurans with arenes: synthesis of 2-arylbenzofurans, Category: isoquinoline, the main research area is halobenzofuran arene acid promotor cross coupling reaction; aryl benzofuran preparation.

Transition-metal-free acid-promoted biaryl construction was achieved via intermol. C-F/C-H cross-coupling. By treating 2-fluorobenzofurans with arenes in the presence of AlCl3, 2-arylbenzofurans were obtained. This protocol was successfully applied to the short-step orthogonal synthesis of a bioactive 2-arylbenzofuran natural product, which allows independent transformations of C-F and C-Br bonds. Mechanistic studies indicated that α-fluorine-stabilized carbocations, generated via the protonation of 2-fluorobenzofurans, served as key intermediates. The Friedel-Crafts-type C-C bond formation between the α-fluorocarbocations and arenes, followed by hydrogen fluoride elimination, afforded 2-arylbenzofurans.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Pei, Xiaocong published the artcileSterically controlled C-H/C-H homocoupling of arenes via C-H borylation, Category: isoquinoline, the main research area is biaryl preparation regioselective; arene borylation homocoupling iridium copper catalyst.

A mild one-pot protocol for the synthesis of biaryls R-R [R = 3-chloro-5-methylphenyl, 3-bromo-2-fluoro-5-(trifluoromethyl)phenyl, naphth-2-yl, etc.] by sequential Ir-catalyzed C-H borylation and Cu-catalyzed homocoupling of arenes RH has been described. The regiochem. of the biaryls is sterically controlled as dictated by the C-H borylation step. The methodol. is also successfully extended to heteroarenes R1H (R1 = benzofuran-2-yl, 2-methylthiophen-5-yl, 3-chloropyridin-5-yl, etc.). Some of the products obtained by this approach are impossible to obtain via Ullmann or Suzuki coupling protocols. Finally, one-pot sequence describing C-H borylation/Cu-catalyzed homocoupling/Pd-catalyzed Suzuki coupling to obtain π-extended arene framework has been reported.

Organic & Biomolecular Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ding, Siyi published the artcileNNB-type tridentate boryl ligands enabling a highly active iridium catalyst for C-H borylation, Related Products of isoquinoline, the main research area is boryl ligand preparation iridium complex catalyst carbon hydrogen borylation; C–H borylation reaction; boryl ligand; iridium-catalyzed.

Boryl ligands play a very important role in catalysis because of their very high electron-donating property. NNB-type boryl anions were designed as tridentate ligands to promote aryl C-H borylation. In combination with [IrCl(COD)]2, they generate a highly active catalyst for a broad range of (hetero)arene substrates, including highly electron-rich and/or sterically hindered ones. This work provides a new NNB-type tridentate boryl ligand to support homogeneous organometallic catalysis.

Molecules published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Das, Arpan published the artcileNickel-Catalyzed C(sp2)-H Borylation of Arenes, Application In Synthesis of 151-10-0, the main research area is phenylimidazolidene NHC carbene cyclometalated nickel cyclooctadiene preparation crystal structure; catalyzed borylation alkyl alkoxy arene phenylimidazolidene carbene cyclometalated nickel; arylated boron compound preparation.

In this study, C(sp2)-H borylation of arenes was accomplished by a nickel catalyst, resulting in good yield. Alkyl and alkoxy arenes were successfully functionalized, affording C(sp2)-H borylated compounds It was unraveled that the well-defined abnormal N-heterocyclic carbene based Ni(II) complex breaks into Ni nanoparticles (Ni-NPs), which act as catalytically active species. A series of controlled reactions under stoichiometric conditions along with spectroscopic studies and single-crystal x-ray crystallog. study helped us to understand the formation of Ni-NPs along with formation of a boron(III) compound during this reaction.

Organometallics published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Haiwei published the artcileTwo Ligands Transfer from Ag to Pd: En Route to (SIPr)Pd(CF2H)(X) and Its Application in One-Pot C-H Borylation/Difluoromethylation, Computed Properties of 151-10-0, the main research area is fluoromethyl palladium imidazolinylidene complex preparation crystal structure fluoromethylation catalyst; crystal structure fluoromethyl palladium arylimidazolinylidene complex; mol structure fluoromethyl palladium arylimidazolinylidene complex; hetero arene borylation difluoromethylation palladium catalyst; fluoromethylated heteroarene preparation.

A process for the concurrent transfer of both the NHC ligand and difluoromethyl group from [(SIPr)Ag(CF2H)] to PdX2 (X = Cl, OAc and OPiv) for the preparation [(SIPr)Pd(CF2H)X] complexes is described. These complexes were air-stable and easily underwent transmetalation with aryl pinacol boronate/reductive elimination to generate ArCF2H in high yields. Based on this discovery, the 1st 1-pot C-H borylation and difluoromethylation for the preparation of difluoromethylated (hetero)arenes was developed.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem