Tag: M.W=100-150

Fischer, Oliver published the artcileShifted Selectivity in Protonation Enables the Mild Deuteration of Arenes Through Catalytic Amounts of Bronsted Acids in Deuterated Methanol, Product Details of C8H10O2, the main research area is Bronsted acid catalyzed deuteration arene deuterated methanol.

Taking advantage of the “”differentiating effect”” of the solvent methanol, deuterations of electron-rich aromatic systems can be carried out under mild acid catalysis and thus under far milder conditions than known so far. The exceptional functional group tolerance observed under the optimized conditions, which even includes highly acid-labile groups, results from a hitherto unexploited shifted selectivity in protonation, and enabled simple and straightforward access to complex deuterium-labeled compounds

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Rokade, Balaji V. published the artcileSynthesis of α-Aryl-Oxindoles by Friedel-Crafts Alkylation of Arenes, Related Products of isoquinoline, the main research area is arylindole preparation; isatin diethylphosphite arene phospho Brook rearrangement Friedel Crafts reaction.

Synthesis of α-aryl-oxindoles was reported from isatin via a two-step procedure involving a phospha-Brook rearrangement and a Friedel-Crafts alkylation in a one-pot procedure. The use of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent significantly extended the reaction substrate scope to include relatively less electron rich arenes including benzene. This new alkylation method is fast, straightforward and allows for the direct introduction of the oxindole moiety onto a range of aromatic compounds including phenols. Addnl., the application of arylated products was shown in decarboxylative asym. allylation and protonation.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kalaramna, Pratibha published the artcileTransition-Metal-Free HFIP-Mediated Organo Chalcogenylation of Arenes/Indoles with Thio-/Selenocyanates, Category: isoquinoline, the main research area is HFIP mediated chalcogenylation arene indole aryl chalcogenocyanate; chalcogenide synthesis.

We have developed a protocol for the synthesis of diaryl thio-/selenoethers by the reaction of aryl chalcogenocyanates with electron rich arenes/hetero arenes via HFIP promoted C-H activation. The reaction produces chalcogenides in good to excellent yields under mild conditions without the need of a transition metal as a catalyst. The HFIP-mediated reactions tolerated a wide range of functional groups and set the stage for the synthesis of diversely decorated chalcogenides. A mechanism involving activation of the C-H bond through hydrogen bonding is proposed.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Paul, Sanjay published the artcilePd(TFA)2-Catalyzed direct arylation of quinoxalinones with arenes, Name: 1,3-Dimethoxybenzene, the main research area is aryl quinoxalinone regioselective preparation; quinoxalinone arene cross coupling.

The direct C-3 arylation of quinoxalin-2-ones with arenes was achieved by a Pd(TFA)2-catalyzed cross-dehydrogenative coupling (CDC) reaction. A wide array of functionalities, including highly sensitive allyl- and benzyl group substituted quinoxalin-2(H)-ones I [R = Me, geranyl, Bn, 4-ClBn 4-MeBn; R1 = H, Me, F, Cl, Br, COOMe; R2 = H, Me, F, Cl, Br; R3 = Ph, 2-MeC6H4, 4-FC6H4, etc.], were readily assembled with arenes containing electron-donating and electron-withdrawing groups in this CDC reaction. Highly regioselective products were produced in good yields with stronger electron-donating groups than toluene and densely substituted arenes as coupling partners. This protocol represented an efficient technique to access various 3-arylbenzo[g]quinoxalinones II [R4 = Me, Bn; R5 = Ph, 4-ClC6H4, 4-OMeC6H4] and 2-aryl-4-methylpyrido[3,4-b]pyrazin-3(4H)-ones under mild conditions.

Organic Chemistry Frontiers published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Dong published the artcileTrifluoromethyl Sulfoxides: Reagents for Metal-Free C-H Trifluoromethylthiolation, HPLC of Formula: 151-10-0, the main research area is aryl heteroaryl trifluoromethyl thioether regioselective preparation; trifluoromethyl sulfoxide regioselective trifluoromethylthiolation heteroarene mediated triflic anhydride diethylamine; regioselective trifluoromethylation arene trifluoromethyl sulfoxide mediated triflic anhydride diethylamine; ethoxycarbonylmethyl methylphenyl trifluoromethylsulfonium triflate mol crystal structure; Pummerer reaction; arenes; reaction mechanisms; sulfoxides; trifluoromethylthiolation.

Indoles, pyrroles, thiophenes, a benzothiophene, a benzofuran, and arenes underwent metal-free regioselective trifluoromethylthiolation with trifluoromethyl sulfoxides RCH2S(:O)CF3 (R = Ph, EtO2C) mediated by triflic anhydride and diethylamine in acetonitrile or nitromethane to yield heteroaryl and aryl trifluoromethyl thioethers. An aryl(ethoxycarbonylmethyl)(trifluoromethyl)sulfonium triflate was isolated as a trifluoromethylthiolation intermediate and its structure determined by X-ray crystallog., supporting an interrupted Pummerer reaction mechanism for the trifluoromethylthiolation.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jud, Wolfgang published the artcileCathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex, Safety of 1,3-Dimethoxybenzene, the main research area is cathodic fluoromethylation arene heteroarene in situ triflyltriethylammonium complex.

While several trifluoromethylation reactions involving the electrochem. generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes is reported. The method is based on the electrochem. reduction of an unstable triflyltriethylammonium complex generated in situ from inexpensive triflyl chloride and triethylamine, which produces CF3 radicals that are trapped by the arenes on the cathode surface.

Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Hongru published the artcileGraphene-Oxide-Catalyzed Cross-Dehydrogenative Coupling of Oxindoles with Arenes and Thiophenols, HPLC of Formula: 151-10-0, the main research area is graphene oxide catalyst dehydrogenative coupling oxindole arene thiophenol.

Here, the authors explore the GO-catalyzed cross-dehydrogenative coupling of oxindoles with arenes and thiophenols for the rapid synthesis of 3-aryloxindoles and 3-sulfenylated oxindoles. Control experiments and small-mol. mimicking studies reveal that the acidic nature and quinone-type functionalities of GO are synergistically used for the coupling reaction. The reaction proceeds under simple and mild reaction conditions, exhibits good functional group tolerance, and can be easily scaled up to the gram level.

Advanced Synthesis & Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Chao published the artcileFeCl3-catalyzed three-component aryl-selenylation of alkenes, Category: isoquinoline, the main research area is diarylethyl arylselane preparation; alkene aromatic hydrocarbon diselenide three component selenylation iron catalyst.

FeCl3-catalyzed three-component aryl-selenylation of alkenes 4-R-C6H4CH=CH2 (R = H, F, Me, Ph, etc.) with good to excellent yields has been disclosed. This method is characterized by synthesis of complicated products 4-R-C6H4CH(Ar)CH2Se(2-R1-3-R2-4-R3C6H2) [Ar = 2,4,6-trimethoxyphenyl, 2,4-dimethoxyphenyl, 1H-indol-3-yl, etc.; R1 = H, Cl; R2 = H, Me; R3 = H, F, Cl, Br, Me, OMe, CF3] in a single-step reaction, simple operation and readily available com. reagents. Finally, a reasonable mechanism of FeCl3-catalyzed aryl-selenylation is proposed.

Tetrahedron published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Qinghua published the artcileAccess to Phenothiazine Derivatives via Iodide-Mediated Oxidative Three-Component Annulation Reaction, Related Products of isoquinoline, the main research area is phenothiazine preparation iodide annulation aniline cyclohexanone sulfur.

Herein, a new iodide-mediated three-component annulation reaction of secondary anilines, cyclohexanones, and elemental sulfur is demonstrated, which allows access to various phenothiazines with the merits of formation of multiple chem. bonds in one single operation, high step and atom efficiency, readily available feedstocks and catalyst system, and good substrate and functional group compatibility. The developed chem. capable of constructing novel phenothiazines with structural diversity offers a significant basis for further applications.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (secondary). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Huang, Shuang published the artcileBimetallic Bis-NHC-Ir(III) Complex Bearing 2-Arylbenzo[d]oxazolyl Ligand: Synthesis, Catalysis, and Bimetallic Effects, COA of Formula: C8H11NO, the main research area is potential energy surface iridacycle complex catalyzed methylation aniline DFT; bimetallic biscarbene iridium complex containing arylbenzooxazolyl ligand preparation catalyst; crystal structure bimetallic biscarbene iridium complex containing arylbenzooxazolyl ligand; mol structure bimetallic biscarbene iridium complex containing arylbenzooxazolyl ligand; isotope effect iridium carbene complex catalyzed methylation aniline.

Herein, an unprecedented bimetallic bis-NHC Cp*Ir complex 1 bearing 2-arylbenzo[d]oxazolyl and NHC ligands is reported. A significantly increase in activity was observed for N-methylation of amines and reduction of aldehydes with MeOH catalyzed by 1 compared to the monometallic analogs (2-11). Under the optimal conditions, it showed to be highly effective in N-methylation of nitroarenes with MeOH as both C1 and H2 source. Substrates, including aromatic amines, ketones and nitro compounds with various functional groups, can be well tolerated. Mechanistic studies and DFT calculation highlights the significance of bimetallic centers cooperativity.

Organometallics published new progress about Anilines Role: SPN (Synthetic Preparation), PREP (Preparation) (N-Me). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem