Tag: M.W=100-150

Pan, Aaron published the artcileSynergistic Bronsted/Lewis acid catalyzed aromatic alkylation with unactivated tertiary alcohols or di-tert-butylperoxide to synthesize quaternary carbon centers, Product Details of C8H10O2, the main research area is aromatic hydrocarbon ditert butylperoxide acid catalyst regioselective alkylation green; tertiary alc aromatic hydrocarbon acid catalyst regioselective alkylation green; quaternary alkylarene preparation.

Dual Bronsted/Lewis acid catalysis involving environmentally benign, readily accessible protic acid and iron promotes site-selective tert-butylation of electron-rich arenes using di-tert-butylperoxide. This transformation inspired the development of a synergistic Bronsted/Lewis acid catalyzed aromatic alkylation that fills a gap in the Friedel-Crafts reaction literature by employing unactivated tertiary alcs. as alkylating agents, leading to new quaternary carbon centers. Corroborated by DFT calculations, the Lewis acid serves a role in enhancing the acidity of the Bronsted acid. The use of non-allylic, non-benzylic, and non-propargylic tertiary alcs. represents an underexplored area in Friedel-Crafts reactivity.

Chemical Science published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Singh, Dileep Kumar published the artcileOne-pot, three-component approach to diarylacetonitriles, Formula: C8H10O2, the main research area is aromatic aldehyde heteroarene trimethylsilyl cyanide three component reaction; diarylacetonitrile preparation one pot.

A novel one-pot, three-component reaction where aldehydes, electron-rich arenes, and TMSCN in the presence of BF3-OEt2 allowed direct access to a number of diarylacetonitriles under mild reaction conditions in good to excellent yields. Implementation of this assembly protocol to a concise synthetic approach to shoreaphenol, a bioactive oligostilbenoid natural product, was also demonstrated.

Organic Chemistry Frontiers published new progress about Acetonitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Yangsen published the artcilePhotocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride, Product Details of C8H11NO, the main research area is photocatalytic water splitting coupled alkanol oxidation; nitrogen alkylation palladium carbon nitride catalyst green chem; N-alkylation reaction; alkanol oxidation; carbon nitride; photocatalysis; water splitting.

Photocatalytic water splitting technol. (PWST) enables the direct use of water as appealing “”liquid hydrogen source”” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technol. highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chems. and pharmaceuticals from nitroarenes and amines with water and alkanols.

ChemSusChem published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Braun, Carolin published the artcilePlanar-chiral [2.2]Paracyclophane-based Pyridonates as Ligands for Tantalum-catalyzed Hydroaminoalkylation, HPLC of Formula: 5961-59-1, the main research area is planar chiral paracyclophane pyridonate ligand tantalum catalyzed hydroaminoalkylation.

By using planar chiral [2.2]paracyclophane-containing N,O-chelating ligands for tantalum-catalyzed hydroaminoalkylation, one of the most versatile catalytic systems for this reaction to date was obtained [e.g., 4-methoxy-N-methylaniline + 1-octene I (90%)]. Convenient Csp3-Csp3 bond formation of amines with terminal and internal alkenes was enabled by the same in situ synthesized catalytic system of [2.2]paracyclophane-based pyridonates and Ta(CH2TMS)3Cl2 that shows also very promising results for N-containing heterocycles.

ChemCatChem published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (internal). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vayer, Marie published the artcilePotassium Carbonate to Unlock a GaCl3-Catalyzed C-H Propargylation of Arenes, COA of Formula: C8H10O2, the main research area is electron rich arene bromoallene carbon hydrogen propargylation; gallium chloride catalyst potassium carbonate base.

A gallium-catalyzed C-H propargylation of electron-rich arenes using bromoallenes is described. The development of this reaction was first hampered by a side hydroarylation process catalyzed by adventitious protons, easily generated from the solvent (1,2-dichloroethane). This hidden Bronsted acid catalysis could be bypassed by using K2CO3 as insoluble base. The unexpected compatibility of this base with the Lewis acid catalyst GaCl3 allowed a strictly gallium-catalyzed process that was thoroughly studied by kinetics, 71Ga NMR experiments and DFT computations. The GaCl3/K2CO3 system triggers the C-H propargylation of a wide range of arenes and heteroaromatics using a variety of bromoallenes.

ACS Catalysis published new progress about Alkynes, aryl Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Magre, Marc published the artcileN-Methylation and Trideuteromethylation of Amines via Magnesium-Catalyzed Reduction of Cyclic and Linear Carbamates, Formula: C8H11NO, the main research area is methylation trideuteromethylation amine magnesium catalyst; cyclic linear carbamate reduction.

A new reduction of carbamates to N-Me amines is presented. The magnesium-catalyzed reduction reaction allows the conversion of cyclic and linear carbamates, including N-Boc protected amines, into the corresponding N-Me amines and amino alcs. which are of significant interest due to their presence in many biol. active mols. Furthermore, the reduction can be extended to the formation of N-trideuteromethyl labeled amines.

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (N-Me). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chaudhary, Priyanka published the artcileRegioselective Nitration of N-Alkyl Anilines using tert-Butyl Nitrite under Mild Condition, Recommanded Product: 4-Methoxy-N-methylaniline, the main research area is regioselective ring nitration alkyl aniline tert butyl nitrite.

Regioselective ring nitration of N-alkyl anilines is reported using tert-Bu nitrite. The reactions proceed efficiently with a wide range of substrates providing synthetically useful N-nitroso N-alkyl nitroanilines in excellent yields which can be easily converted into N-alkyl phenylenediamines and N-alkyl nitroanilines using Zn-AcOH and HCl/MeOH, resp.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent) (N-alkyl). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Recommanded Product: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Esteruelas, Miguel A. published the artcileDirect C-H Borylation of Arenes Catalyzed by Saturated Hydride-Boryl-Iridium-POP Complexes: Kinetic Analysis of the Elemental Steps, Safety of 1,3-Dimethoxybenzene, the main research area is carbon hydrogen bond borylation arene catalyst boryliridium hydride; isotope effect borylation arene catalyst boryliridium hydride; reductive elimination kinetics boryl iridium hydride pincer complex; B−H activation; C−H activation; arene borylation; iridium; pincer ligand.

The saturated trihydride IrH3{κ3-P,O,P-[xant(PiPr2)2]} (1; xant(PiPr2)2 = 9,9-dimethyl-4,5-bis(diisopropylphosphino)xanthene) activates the B-H bond of two mols. of pinacolborane (HBpin) to give H2, the hydride-boryl derivatives IrH2(Bpin){κ3-P,O,P-[xant(PiPr2)2]} (2) and IrH(Bpin)2{κ3-P,O,P-[xant(PiPr2)2]} (3) in a sequential manner. Complex 3 activates a C-H bond of two mols. of benzene to form PhBpin and regenerates 2 and 1, also in a sequential manner. Thus, complexes 1, 2, and 3 define two cycles for the catalytic direct C-H borylation of arenes with HBpin, which have dihydride 2 as a common intermediate. C-H bond activation of the arenes is the rate-determining step of both cycles, as the C-H oxidative addition to 3 is faster than to 2. The results from a kinetic study of the reactions of 1 and 2 with HBpin support a cooperative function of the hydride ligands in the B-H bond activation. The addition of the B atom of the borane to a hydride facilitates the coordination of the B-H bond through the formation of κ1- and κ2-dihydrideborate intermediates.

Chemistry – A European Journal published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gairola, Deepti published the artcileMethanesulfonic Acid Catalyzed Friedel-Crafts Reaction of Electron-Rich Arenes with N-Arylmaleimides: A Highly Efficient Metal-Free Route To Access 3-Arylsuccinimides, SDS of cas: 151-10-0, the main research area is succinimide diaryl green preparation; maleimide aryl Friedel Crafts coupling arene methanesulfonic acid catalyst.

Herein, a highly efficient, metal-free and environmentally benign protocol for the synthesis of 3-arylsuccinimides I [R = Ph, 4-MeOC6H4, 3-Cl-4-MeOC6H3, etc.; Ar = 2,4-(MeO)2C6H3, 2,4-(HO)2C6H3, 2,4,6-(MeO)3C6H2, 2-hydroxy-1-naphthyl, 1-methyl-3-indolyl] in high yields via F-C coupling of electron-rich arenes with N-arylmaleimides in the presence of a green reagent methanesulfonic acid under mild reaction conditions has been developed.

Synthesis published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lu, Shiyao published the artcileFriedel-Crafts trifluoromethylthiolation of electron-rich (hetero)arenes with trifluoromethylthio-saccharin in 2,2,2-trifluoroethanol (TFE), SDS of cas: 151-10-0, the main research area is arene trifluoromethylthio saccharin Friedel Crafts trifluoromethylthiolation; trifluoromethylthio arene preparation.

A promoter-free Friedel-Crafts trifluoromethylthiolation of electron-rich arenes and heteroarenes with N-trifluoromethylthiosaccharin using 2,2,2-trifluoroethanol (TFE) as the solvent was described. The reactions were conducted at 40° and a variety of common functional groups were compatible.

Chinese Chemical Letters published new progress about Aromatic compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem