Tag: M.W=100-150

Yao, Wubing published the artcileSodium Triethylborohydride-Catalyzed Controlled Reduction of Unactivated Amides to Secondary or Tertiary Amines, Quality Control of 5961-59-1, the main research area is secondary tertiary amine preparation; tertiary amide reduction sodium triethylborohydride catalyst.

The first transition-metal-free catalytic protocol for controlled reduction of amide functions using cheap and bench-stable hydrosilanes as reducing agents has been established. By altering the hydrosilane and solvent, the new method enables the selective cleavage of unactivated C-O bonds in amides and allows the C-N bonds to selectively break via the deacylated cleavage. Overall, this novel process may offer a versatile alternative to current methodologies employing stoichiometric metal systems for the controlled reduction of carboxamides.

Journal of Organic Chemistry published new progress about Amides, tertiary Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hu, Sha published the artcileTfOH-Catalyzed N-H Insertion of α-Substituted-α-Diazoesters with Anilines Provides Access to Unnatural α-Amino Esters, COA of Formula: C8H11NO, the main research area is alpha amino ester preparation regioselective chemoselective; diazoester aniline insertion triflic acid catalyst.

A time-economical TfOH-catalyzed N-H insertion between anilines and α-alkyl and α-aryl-α-diazoacetates provides a straightforward approach to access unnatural α-amino esters, which readily underwent various transformations and can thus be used for the synthesis of pharmaceutically relevant mols. The α-amino esters were obtained in moderate to excellent yields.

Journal of Organic Chemistry published new progress about Amino esters Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ojha, Subhadra published the artcileN-Methoxy arenesulfonamide as a Sulfonyl Equivalent For Palladium-Catalyzed Sulfonylation of Arenes Through C-H Activation, Formula: C8H10O2, the main research area is diaryl sulfone preparation; arene methoxy arenesulfonamide sulfonylation carbon hydrogen activation palladium catalyst.

A palladium-catalyzed protocol for synthesizing diaryl sulfones RS(O)2R1 (R = Ph, 1-naphthyl, 2-thienyl, etc.; R1 = Ph, 2,4,6-trimethylphenyl, 2-naphthyl, etc.) from the arenes R1H through C-H activation is described. N-methoxy arenesulfonamide RS(O)2NHOMe was exploited as a potential sulfonyl donor by the cleavage of S-N bond through a radical pathway. The present methodol. has several advantages: a simple, readily available catalytic system; the use of a stable sulfonyl donor; a relatively moderate excess of arene coupling partner for an undirected C-H activation process, along with the tolerances of aryl bromides and iodides, which in turn permits further cross-coupling reactions to afford cross-coupled sulfones.

Asian Journal of Organic Chemistry published new progress about Arenesulfonamides Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Prasad, Sure Siva published the artcileOne-pot access to 2-amino-3-arylbenzofurans: direct entry to polyheterocyclic chemical space, Quality Control of 151-10-0, the main research area is amino arylbenzofuran preparation; aryl aldehyde trimethylsilyl cyanide aromatic alc coupling reaction.

Two efficient one-pot sequential coupling routes to 2-amino-3-arylbenzofurans and 2-amino-3-arylnaphtho[2,1-b]furans I (R = Cl, propan-2-yl, Ph, etc.; R1 = H, OMe, Ph; RR1 = -OCH2O-; R2 = H, Me; R3 = H, OMe; RR3 = -CH=CH-CH=CH-; Ar = 4-hydroxy-3-methoxyphenyl, thiophen-2-yl, 6-bromo-2H-1,3-benzodioxol-5-yl, etc.) were established. Further ring formation (six- and seven-membered rings) with the resulting amine moiety at the C2 position of benzofurans I were realized, leading to further expansion of benzofuran-based chem. space.

Organic & Biomolecular Chemistry published new progress about Aromatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Omrani, Assia published the artcileBi(OTf)3-catalyzed regioselective arylation of Morita-Baylis-Hillman type allylic electrophiles, COA of Formula: C8H10O2, the main research area is allylic electrophile arene bismuth triflate regioselective Friedel Crafts arylation; aryl alkenone preparation.

The Friedel-Crafts reaction of a wide variety of arenes and heteroarenes was accomplished, in good to excellent yields (50-98%) and with high α-regioselectivity, using Morita-Baylis-Hillman acetates. Functionalized conjugated enones were obtained under Bi(OTf)3 catalysis (10 mol%) in dichloroethane (DCE) at 50°.

Tetrahedron Letters published new progress about Aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, COA of Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jia, Shikun published the artcileTrapping of Zwitterionic Intermediates by Isatins and Imines: Synthesis of Benzoxazines Bearing a C4-Quaternary Stereocenter, Computed Properties of 5961-59-1, the main research area is benzoxazine preparation zwitterion intermediate isatin imine.

Benzoxazines bearing a C4-quaternary stereocenter were accomplished via the rhodium-catalyzed electrophilic trapping of zwitterionic intermediates by isatins and imines, resp. The key intermediates of the strategy are proposed to generate from the reaction of donor-acceptor rhodium carbenes with secondary amides. Usage of chiral BINOL-phosphoric acid co-catalyst resulted in enrichment of enantioselectivity in the trapping process with imines.

Organic Letters published new progress about Benzoxazines Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ruiz-Moyano, Santiago published the artcileSelection and application of antifungal VOCs-producing yeasts as biocontrol agents of grey mould in fruits, Related Products of isoquinoline, the main research area is antifungal volatile compound yeast gray mold fruit; Antifungal volatile compounds; Botrytis cinerea; Cherry; Postharvest; Strawberry.

Rotting caused by gray mold (Botrytis cinerea) is a concerning disease for numerous crops both pre- and postharvest stages. Application of antagonistic yeasts is a promising strategy for controlling gray mold incidence which could mitigate undesirable consequences of using synthetic fungicides. In this work, a screening for detection of yeasts isolated from figs producers of antifungal volatile organic compounds (VOCs) were performed by confrontation in double dishes systems. Eleven out of 34 yeasts confronted reduced B. cinerea growth parameter in vitro. This reduction was correlated (p ≤ 0.050) with the production of 10 volatile compounds: two acids (acetic acid and octanoic acid), 7 esters (Et propionate, n-Pr acetate, Iso-Bu acetate, 2-methylbutyl acetate, furfuryl acetate, phenylmethyl acetate, 2-phenylethyl acetate) and one ketone (Heptan-2-one). In bases on in vitro assay, Hanseniaspora uvarum 793 was applied to in vivo assays with strawberries and cherries. The reduction of incidence of B. cinerea in strawberries at 7°C and 25°C was 54.9 and 72.1% after 6 and 3 days, resp. The reduction of incidence of B. cinerea in cherries at 7°C and 25°C was 48.9 and 45.6% after 5 and 4 days, resp. These results showed that VOCs produced by Hanseniaspora uvarum 793 are effective in the control of incidence of Botrytis cinerea in fruits, being a potential alternative to chem. fungicide.

Food Microbiology published new progress about Acyclic hydrocarbons Role: ANT (Analyte), ANST (Analytical Study). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sarki, Naina published the artcileSimple RuCl3-catalyzed N-Methylation of Amines and Transfer Hydrogenation of Nitroarenes using Methanol, Computed Properties of 5961-59-1, the main research area is amine preparation methylation; nitroarene transfer hydrogenation RuCl3 catalyst.

Methanol is a potential hydrogen source and C1 synthon, which finds interesting applications in both chem. synthesis and energy technologies. The effective utilization of this simple alc. in organic synthesis is of central importance and attracts scientific interest. Herein, a clean and cost-competitive method with the use of methanol as both C1 synthon and H2 source for selective N-methylation of amines by employing relatively cheap RuCl3.xH2O as a ligand-free catalyst. This readily available catalyst tolerates various amines comprising electron-deficient and electron-donating groups and allows them to transform into corresponding N-methylated products in moderate to excellent yields. In addition, few marketed pharmaceutical agents (e.g., venlafaxine and imipramine) were also successfully synthesized via late-stage functionalization from readily available feedstock chems., highlighting synthetic value of this advanced N-methylation reaction. Using this platform, also attempted tandem reactions with selected nitroarenes to convert them into corresponding N-methylated amines using MeOH under H2-free conditions including transfer hydrogenation of nitroarenes-to-anilines and prepared drug mols. (e.g., benzocaine and butamben) as well as key pharmaceutical intermediates. Further enable one-shot selective and green syntheses of 1-methylbenzimidazole using ortho-phenylenediamine (OPDA) and methanol as coupling partners.

ChemCatChem published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jamil, A. R. Md. published the artcileN-Methylation of amines and nitroarenes with methanol using heterogeneous platinum catalysts, HPLC of Formula: 5961-59-1, the main research area is amine nitroarene methylation methanol heterogeneous platinum catalysis.

Herein the selective N-methylation of amines and nitroarenes with methanol under basic conditions using carbon-supported Pt nanoparticles (Pt/C) as a heterogeneous catalyst was reported. This method is widely applicable to four types of N-methylation reactions: (1) N,N-dimethylation of aliphatic amines under N2, (2) N-monomethylation of aliphatic amines under 40 bar H2, (3) N-monomethylation of aromatic amines under N2, and (4) tandem synthesis of N-Me anilines from nitroarenes and methanol under 2 bar H2. All these reactions under the same catalytic system showed high yields of the corresponding methylamines for a wide range of substrates, high turnover number (TON), and good catalyst reusability. Mechanistic studies suggested that the reaction proceeded via a borrowing hydrogen methodol. Kinetic results combined with d. functional theory (DFT) calculations revealed that the high performance of Pt/C was ascribed to the moderate metal-hydrogen bond strength of Pt.

Journal of Catalysis published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kumar, Arun published the artcileCatalyst free N-formylation of aromatic and aliphatic amines exploiting reductive formylation of CO2 using NaBH4, Category: isoquinoline, the main research area is aromatic aliphatic amine formylation sodium borohydride carbon dioxide.

Herein, a sustainable approach for N-formylation of aromatic as well as aliphatic amines using sodium borohydride and carbon dioxide gas is reported. The developed approach is catalyst free, and does not need pressure or a specialized reaction assembly. The reductive formylation of CO2 with sodium borohydride generates formoxy borohydride species in situ, as confirmed by 1H and 11B NMR spectroscopy. The in situ formation of formoxy borohydride species is prominent in formamide based solvents and is critical for the success of the N-formylation reactions. The formoxy borohydride is also found to promote transamidation reactions as a competitive pathway along with reductive functionalization of CO2 with amine leading to N-formylation of amines.

RSC Advances published new progress about Aliphatic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem