Tag: M.W=100-150

Ponpao, Nipaphorn published the artcileMetal- and solvent-free synthesis of aniline- and phenol-based triarylmethanes via Bronsted acidic ionic liquid catalyzed Friedel-Crafts reaction, Product Details of C8H10O2, the main research area is benzene aryl aldehyde ionic liquid catalyst Friedel Crafts reaction; phenol aryl aldehyde ionic liquid catalyst Friedel Crafts reaction; aromatic amine aldehyde ionic liquid catalyst Friedel Crafts reaction; triarylmethane preparation regioselective green chem.

A beneficial, scalable and efficient methodol. for the synthesis of aniline-based triarylmethanes was established through the double Friedel-Crafts reaction of com. aldehydes and primary, secondary or tertiary anilines using Bronsted acidic ionic liquid as a powerful catalyst, namely [bsmim][NTf2] (4-sulfono-1-butylmethylimidazolium trifluoromethanesulfonimide). This protocol was successfully performed under metal- and solvent-free conditions with a broad range of substrates, giving the corresponding aniline-based triarylmethane products in good to excellent yields (up to 99%). In addition, alternative aromatic nucleophiles such as phenols and electron-rich arenes were also studied using this useful approach to achieve a diversity of triarylmethane derivatives in high to excellent yields.

RSC Advances published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wexler, Ryan P. published the artcileElectrochemically Enabled Chan-Lam Couplings of Aryl Boronic Acids and Anilines, COA of Formula: C8H11NO, the main research area is aryl amine preparation; aniline aryl boronic acid Chan Lam coupling reaction.

The Chan-Lam reaction remains a highly utilized transformation for C-N bond formation. However, anilines remain problematic substrates due to their lower nucleophilicity. To address this problem, we developed an electrochem. mediated Chan-Lam coupling of aryl boronic acids and amines utilizing a dual copper anode/cathode system. The mild conditions identified have enabled the preparation of a wide range of functionalized biarylanilines in good yields and chemoselectivities.

Organic Letters published new progress about Chan-Lam coupling reaction. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jiang, Lei published the artcileSelective N-Monomethylation of Anilines with Methanol Catalyzed by Commercial Pd/C as an Efficient and Reusable Catalyst, SDS of cas: 5961-59-1, the main research area is monomethyl aniline preparation chemoselective; amine aryl methanol palladium catalyst chemoselective methylation.

In this paper, the N-monomethylation of aniline derivatives using Pd/C catalyst and methanol as the methylation reagent was investigated. The N-monomethylation of various aryl amines was achieved with high activity and selectivity under relatively mild reaction conditions, and the yield of N-monomethyl anilines ArNHMe [Ar = Ph, 4-pyridyl, 2-MeC6H4, etc.] was over 90 %. Notably, the com., readily available, and inexpensive heterogeneous catalyst, Pd/C, could be easily recovered and reused more than five times with only a slight decrease in activity; gram-scale experiments were also successfully performed.

Asian Journal of Organic Chemistry published new progress about Chemoselectivity. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Chen published the artcileA robust and facile method for desulfonation to amines, Formula: C8H11NO, the main research area is amine preparation; aromatic aliphatic sulfonamide desulfonation.

In this study, a robust and facile method for desulfonation to achieve secondary amines is demonstrated. Diphenylphosphine (Ph2PH) was shown to significantly expedite the cleavage of sulfonamides under basic conditions. Aromatic and aliphatic sulfonamides were cleanly converted, with a rapid reaction time, into the required amines with good to excellent chem. yields. Moreover, the functional groups tested were generally well tolerated.

Organic Chemistry Frontiers published new progress about Desulfonation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sukowski, Verena published the artcileS,O-Ligand Promoted meta-C-H Arylation of Anisole Derivatives via Palladium/Norbornene Catalysis, Application In Synthesis of 151-10-0, the main research area is biphenyl terphenyl alkoxy preparation; aryl ether regioselective arylation aryl halide palladium norbornene catalyst; Arylation; C−H Activation; Ligand Design; Palladium; Reaction Mechanisms.

Here, a new catalytic system based on palladium/norbornene and an S,O-ligand for the meta-C-H arylation of aryl ethers that significantly outperforms previously reported systems has been developed. The unique ability of this system to employ alkoxyarene substrates bearing electron donating and withdrawing substituents is demonstrated. Addnl., ortho-substituted aryl ethers are well tolerated, overcoming the “”ortho constraint””, which is the necessity to have a meta-substituent on the alkoxyarene to achieve high reaction efficiency, by enlisting novel norbornene mediators. Remarkably, for the first time the monoarylation of alkoxyarenes is achieved efficiently enabling the subsequent introduction of a second, different aryl coupling partner to rapidly furnish unsym. terphenyls. Further insight into the reaction mechanism was achieved by isolation and characterization of some Pd-complexes-before and after meta C-H activation-prior to evaluation of their resp. catalytic activities.

Angewandte Chemie, International Edition published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application In Synthesis of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Yinling published the artcileRedox-neutral photocatalytic strategy for selective C-C bond cleavage of lignin and lignin models via PCET process, Name: 1,3-Dimethoxybenzene, the main research area is phenoxy phenylethanol preparation iridium photocatalyst proton coupled electron transfer; benzaldehyde phenyl ether preparation.

A redox-neutral photocatalytic strategy to accomplish this goal in both β-O-4 and β-1 lignin models at room temperature (RT) via proton-coupled electron transfer (PCET) process without any pretreatments of substrate, by adjusting the alkalinity of base to obtain a lignin models/base PCET pair with a bond dissociation free energy close to 102 kcal/mol was developed. Without breaking down Cβ-Cγ bond and any C-O bonds, this PCET method is 100% atom economy and produces exclusive Cα-Cβ bond cleavage products, such as benzaldehydes (up to 97%) and Ph ethers (up to 96%), in high to excellent yields and selectivities. Preliminary studies indicated that the PCET strategy was also effective for the depolymerization of native lignin at RT, thus providing significantly important foundation to the depolymerization of lignin.

Science Bulletin published new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Hornink, Milene Macedo published the artcileBiobased Spiroimides from Itaconic Acid and Formamides: Molecular Targets for a Novel Synthetic Application of Renewable Chemicals, Synthetic Route of 5961-59-1, the main research area is spiro dihydroquinolinone succinimide spiroindolinone glutarimide preparation; dihydroquinolinone indolinone itaconic acid anhydride formamide Fenton photochem flow.

Herein, a novel synthetic application of renewable chems., itaconic acid and formamides, is described. Proper exploitation of the reactivity of itaconic acid and formamide allows for the development of an efficient synthetic approach for the production of several new biobased spiroimides, spiro[dihydroquinolin-2-one-succinimides] I (R1 = H, Me, Cl, etc.; R2 = Me, Ph, Bn; R3 = H, Me) and spiro[indolin-2-one-glutarimides] II (R1 = H, OMe, CF3; R2 = Me, Bn; R3 = H, Me), in excellent overall yields (up to 98%).

Synthesis published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gou, Quan published the artcileDivergent Regioselective Csp2-H Difluoromethylation of Aromatic Amines Enabled by Nickel Catalysis, Safety of 4-Methoxy-N-methylaniline, the main research area is arylamine bromodifluoroacetate nickel catalyst regioselective difluoromethylation; difluoromethylarene preparation; difluorooxindole preparation.

Herein, the first catalytic protocol for nickel-catalyzed ortho or para position difluoromethylation of various aromatic amines was developed with the assistance of a bidentate phosphine ligand, offering an invaluable synthesis means to construct extensive p-difluoromethylated products and difluorooxindole derivatives with significant functional fragments. Furthermore, the gram-scale reaction, broad substrate scope, excellent functional-group compatibility, late-stage difluoromethylation of pesticides, and even formal synthesis of HDAC6 inhibitors further demonstrate the usefulness of this method.

Organic Letters published new progress about Aromatic amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gennaiou, Kyriaki published the artcileDivergent Synthesis of Bisphenols and Diaryl Ethers by Metal Compatible Organocatalytic Aerobic Oxidation of Boronic Acids, Safety of 1,3-Dimethoxybenzene, the main research area is arylboronic acid diketopiperazine catalyst chemoselective aerobic oxidation; phenol preparation; hydroxybenzene aylboronic acid diketopiperazine catalyst chemoselective oxidative coupling; diaryl ether preparation; bisphenol preparation.

The current study showed that pyrrole-proline 2,5-diketopiperazine (DKP) organocatalyst, in the presence of Hantzsch ester and HFIP was compatible with copper(II) salts for the activation of dioxygen. These findings allowed to selectively diverge the oxidation profile of boronic acids for the synthesis of phenols, bisphenols and diaryl ethers by DKP-promoted aerobic oxidation and subsequent metal oxidative-coupling or Chan-Lam-Evans type reaction of the formed phenols.

Advanced Synthesis & Catalysis published new progress about Chemoselectivity. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Peng published the artcileN-Methylation of Amines with Methanol in the Presence of Carbonate Salt Catalyzed by a Metal-Ligand Bifunctional Ruthenium Catalyst [(p-cymene)Ru(2,2′-bpyO)(H2O)], Synthetic Route of 5961-59-1, the main research area is sulfonamide methanol cesium carbonate ruthenium catalyst methylation green chem; methylsulfonamide preparation; amine methanol cesium carbonate ruthenium catalyst methylation green chem; methylamine preparation.

A ruthenium complex [(p-cymene)Ru(2,2′-bpyO)(H2O)] was found to be a general and efficient catalyst for the N-methylation of amines with methanol in the presence of carbonate salt. Moreover,a series of sensitive substituents such as nitro, ester, cyano and vinyl groups were tolerated under present conditions. It was confirmed that OH units in the ligand were crucial for the catalytic activity. Notably, this research exhibited the potential of metal-ligand bifunctional ruthenium catalysts for the hydrogen auto-transfer process.

Journal of Organic Chemistry published new progress about Amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem