Tag: M.W=100-150

Xu, Rui published the artcileThree-component difluoroalkylamination of alkenes mediated by photoredox and iron cooperative catalysis, Computed Properties of 5961-59-1, the main research area is alkene photochem difluoroalkylamination aryl amine difluorobromoacetate iron catalyst; ester arylamino difluoro preparation.

A three-component difluoroalkylamination of alkenes R1CH:CHR2 (R1 = Ph, 4-MeC6H4, 3-BrC6H4, C6F5, PhCH2, etc., R2 = H; R1 = Ph, R2 = Me) with BrCF2CO2Et and amines R3NHR4 (R3 = Ph, 4-MeC6H4, 4-MeOC6H4, R4 = Me; R3 = Ph, R4 = H) mediated by visible-light photoredox and iron cooperative catalysis to produce fluorinated amino esters R3R4NCHR1CHR2CF2CO2Et is described. Electron rich, electron poor and internal styrenes were all tolerated giving the desired products in good yields. The Csp3-Csp3 and Csp3-N bonds were simultaneously formed under mild conditions. A radical pathway was proposed by exptl. studies.

Organic & Biomolecular Chemistry published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Xuchao published the artcileRedox-Neutral Nickel-Catalyzed Cross-Coupling Reactions of (Homo)allylic Alcohols and Aryltriflates, Computed Properties of 151-10-0, the main research area is alkenyl alc aryltriflate nickel catalyst cross coupling; aryl alkanone preparation.

A redox-neutral Ni-catalyzed cross-coupling reaction of two readily available precursors to produce the corresponding ketones that are an important structural motif in numerous biol. active entities. By the use of a com. available nickel/Triphos catalytic system, a range of easily accessible alkenyl primary alcs. and aryltriflates can be converted in a rapidly assembled fashion to valuable ketones with good yields and wide functional group tolerance. The utility of this transformation shown by late-stage functionalization of a large set of complex mols. with good efficiency, which offers a distinct entry to more functionalized aromatic ketones.

ACS Catalysis published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Computed Properties of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Shaofei published the artcileUnlocking the Friedel-Crafts arylation of primary aliphatic alcohols and epoxides driven by hexafluoroisopropanol, Formula: C8H10O2, the main research area is alc preparation regioselective; epoxide arene ring opening Friedel Crafts arylation Bronstedacid catalyst; arylethane preparation; aliphatic alc arene Friedel Crafts arylation Bronsted acid catalyst.

The limitations thar easily overcome using Bronsted acid catalysis in hexafluoroisopropanol (HFIP) as a solvent were reported. Electron-poor aromatic epoxides and aliphatic epoxides undergo stereospecific arylation to give alcs. RC(R1)(Ar)CH2OH/RCH(OH)CH(Ar)OH, and based on the reaction conditions, it can partake in a second nucleophilic substitution with a different arene ArH in one pot. Ph ethanols R3(CH2)2OH (R3 = Ph, 2,6-dichlorophenyl, 2,4,6-trimethylphenyl, etc.) react through a phenonium intermediate, whereas simple aliphatic alcs. e.g., cyclopentanol participate in a rare intermol. SN2 Friedel-Crafts process, delivering linear products e.g., 1,3,5-trimethyl-2-phenethylbenzene exclusively. In this work, an alternative to metal-catalyzed cross-couplings was provided for accessing important scaffolds, and widening the range of applications of the Friedel-Crafts reaction.

Chem published new progress about Aromatic hydrocarbons Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Formula: C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yadav, Naveen published the artcileRapid Access to Arylated and Allylated Cyclopropanes via Bronsted Acid-Catalyzed Dehydrative Coupling of Cyclopropylcarbinols, Name: 1,3-Dimethoxybenzene, the main research area is cyclopropane preparation regioselective; cyclopropylcarbinol carbon nucleophile allyltrimethylsilane dehydrative coupling Brookhart acid catalyst.

A regioselective protocol for the synthesis of cyclopropyl derivatives that relies on Brookhart acid-catalyzed dehydrative coupling over substituted cyclopropylcarbinols without rearrangement is reported herein. The reactions proceed promptly at 25° with only 2.0 mol % catalyst loading and produce the cyclopropyl derivatives in excellent yields. This method is well tolerated with a vast range of cyclopropylcarbinols including aliphatic cyclopropylcarbinols, where no elimination product was obtained, demonstrating the protocol’s utility. Further, the Hammett correlation suggested the formation of a cyclopropylcarbinyl cation followed by a coupling reaction. An extremely effective gram-scale reaction has also been demonstrated with a high turnover number

Journal of Organic Chemistry published new progress about Bronsted acids Role: CAT (Catalyst Use), USES (Uses). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ma, Wei published the artcileIron-Catalyzed Anti-Markovnikov Hydroamination and Hydroamidation of Allylic Alcohols, COA of Formula: C8H11NO, the main research area is allylic alc iron catalyst anti Markovnikov hydroamination hydroamidation.

Hydroamination allows for the direct access to synthetically important amines. Controlling the selectivity of the reaction with efficient, widely applicable, and economic catalysts remains challenging, however. This paper reports an iron-catalyzed formal anti-Markovnikov hydroamination and hydroamidation of allylic alcs., which yields γ-amino and γ-amido alcs., resp. Homoallylic alc. is also feasible. The catalytic system, consisting of a pincer Fe-PNP complex (1-4 mol %), a weak base, and a nonpolar solvent, features exclusive anti-Markovnikov selectivity, broad substrate scope (>70 examples), and good functional group tolerance. The reaction could be performed at gram scale and applied to the synthesis of drug mols. and heterocyclic compounds When chiral substrates are used, the stereochem. and enantiomeric excess are retained. Further application of the chem. is seen in the functionalization of amino acids, natural products, and existing drugs. Mechanistic studies suggest that the reaction proceeds via two cooperating catalytic cycles, with the iron complex catalyzing a dehydrogenation/hydrogenation process while the amine substrate acts as an organocatalyst for the Michael addition step.

Journal of the American Chemical Society published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Asako, Sobi published the artcileOrganosodium compounds for catalytic cross-coupling, Synthetic Route of 151-10-0, the main research area is organosodium compound preparation cross coupling reaction reactivity.

Herein, it was demonstrate that, contrary to common belief, organosodium compounds can be easily prepared from aryl chlorides or (hetero)arenes and easy-to-handle sodium dispersion and, after being transmetallated to the corresponding zinc and boron compounds, they readily participate in the Negishi and Suzuki-Miyaura cross-coupling reactions, fundamental carbon-carbon bond-forming reactions in organic synthesis. Direct coupling reactions with organosodium species were also possible.

Nature Catalysis published new progress about Aromatic hydrocarbons Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Guo, Wei published the artcilePhotodriven Photocatalyst/Metal-Free Direct C-C/C-N Bond Formation: Synthesis of Indoles via EDA Complexes, Related Products of isoquinoline, the main research area is alkylindoledicarboxylate preparation; photochem aerobic oxidative cycloaddition acetylenedicarboxylate alkylaniline; charge transfer complex methylaniline acetylenedicarboxylate evidence radical mechanism.

Under LED UV irradiation, N-alkylanilines such as N-methylaniline underwent aerobic oxidative cycloaddition reactions with di-Me and di-Et acetylenedicarboxylates mediated by Et3N and C4F9I in MeCN to yield N-alkylindoledicarboxylates such as I without added photocatalysts or metals. The 1:1 complex of N-methylaniline and di-Et acetylenedicarboxylate was detected by NMR, and intermediates in the reaction were observed by mass spectrometry; the reaction was inhibited by radical inhibitors.

Journal of Organic Chemistry published new progress about Charge transfer complexes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Haiyan published the artcileDABCO as a practical catalyst for aromatic halogenation with N-halosuccinimides, Related Products of isoquinoline, the main research area is aromatic compound halosuccinimide DABCO catalyst halogenation; aryl halide regioselective preparation.

A simple and practical synthetic approach for synthesis of aromatic halides was developed. Simple Lewis base, DABCO, was used as the catalyst. This arene halogenation process proceeded conveniently and efficiently at ambient conditions, providing the desired products in good to excellent yields and selectivity.

RSC Advances published new progress about Aryl halides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Takenaga, Naoko published the artcileNucleophilic arylation of halopurines facilitated by Bronsted acid in fluoroalcohol, Related Products of isoquinoline, the main research area is aryl substituted purine preparation; halopurine aromatic compound nucleophilic arylation triflic acid facilitated; aromatic substitution; arylation; fluoroalcohol; nucleobase; purine.

Various aryl-substituted purine derivatives I [Ar = 4-HO-1-naphthyl, 4-MeO-1-naphthyl, 1-Me-indol-3-yl, 1-Ph-indol-3-yl; R = H, Bn] II [Ar1 = 2,4-di-OH, 4-HO-1-naphthyl, 1H-indol-3-yl, etc.] were synthesized through the direct arylation of halopurines with aromatic compounds, facilitated by the combination of triflic acid and fluoroalc. This metal-free method was complementary to conventional coupling reactions using metal catalysts and reagents for the syntheses of aryl-substituted purine analogs.

Molecules published new progress about Arylation. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Prasitwatcharakorn, Watcharapon published the artcileSynthesis of 4-Aryl-1,2-naphthoquinones via a conjugate addition-oxidation reaction catalyzed by p-toluenesulfonic acid, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is aryl naphthoquinone preparation; naphthoquinone arene conjugate addition oxidation para toluenesulfonic acid catalyst.

A catalytic conjugate addition-oxidation reaction of 1,2-naphthoquinones has been investigated. P-Toluenesulfnoic acid was found to be the most effective catalyst for the reaction. This developed method provides a short, simple, convenient, and low-cost synthesis of 4-aryl-1,2-naphthoquinones.

Results in Chemistry published new progress about Biaryls Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem