Tag: M.W=100-150

Zhao, Junyan published the artcileIntramolecular Dehydrogenative Coupling Approach to 2-Oxindoles Using Fe(OAc)2/NaI/Na2S2O8, Quality Control of 5961-59-1, the main research area is oxindone preparation intramol dehydrogenative coupling aniline dicarbonyl.

Oxindole units are common structures that are featuring in natural products and drugs. A novel method for synthesizing 2-oxindoles from 1,3-dicarbonyl compounds based on ferrous salt and iodide catalyst was described. Using Fe(OAc)2/NaI/Na2S2O8, various 2-alkyl-3-phenylamino-3-oxopropanoates, bearing fluoro, chloro, bromo, alkyl, alkoxy, trifluoromethyl, cyano etc. on the benzene ring were converted smoothly into 2-oxindoles.

European Journal of Organic Chemistry published new progress about C-H bond formation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Quality Control of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zanghi, Joseph M. published the artcileEnantio- and Diastereoselective Synthesis of Functionalized Carbocycles by Cu-Catalyzed Borylative Cyclization of Alkynes with Ketones, Safety of 1,3-Dimethoxybenzene, the main research area is diastereoselective copper catalyzed borylative cyclization alkyne ketone alkynylcyclohexanedione; cyclohexandione alkynylation propargyl bromide; diboryl indenone preparation oxidation boryl elimination Martins sulfurane; crystal structure chiral diboryl allyl indenone; mol structure chiral diboryl allyl indenone.

A single-pot Cu-catalyzed enantio- and diastereoselective tandem hydroboration/borylative cyclization of alkynes with ketones for the synthesis of carbocycles is reported. The reaction proceeds via desymmetrization and generates four contiguous stereocenters, including an all-C quaternary center. The method provides rapid access to [6,5]- and [5,5]-bicycles and cyclopentane products. Catalyst-controlled diastereoselectivity by selection of bisphosphine ligand is noted. Utility of the products is demonstrated by site- and chemoselective transformations that afford valuable alkenyl and allyl organoborons.

Organic Letters published new progress about Alkynylation. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Luo, Zhenli published the artcileMetal-Free Reductive Amination of Ketones with Amines Using Formic Acid as the Reductant under BF3 · Et2O Catalysis, Computed Properties of 5961-59-1, the main research area is ketone amine formic acid boron trifluoride etherate reductive amination; alkylamine preparation.

BF3·Et2O was found to effectively catalyze reductive amination of ketones with amines employing formic acid as the reductant under metal-free conditions. This transformation tolerated a broad range of primary and secondary amines and differently decorated ketones, delivering N-alkylated amines in good to excellent yields with high compatibility of functional groups. The synthetic potential of this protocol was demonstrated by its application in the preparation of biol. and pharmaceutically relevant compounds

Asian Journal of Organic Chemistry published new progress about Ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liang, Shuaishuai published the artcileOne-pot synthesis of trifluoromethyl amines and perfluoroalkyl amines with CF3SO2Na and RfSO2Na, Computed Properties of 5961-59-1, the main research area is trifluoromethyl perfluoroalkyl amine preparation; secondary amine sodium fluoroalkylsulfinate trifluoromethylation perfluoroalkylation.

A newly developed CF3SO2Na-based trifluoromethylation of secondary amines has been disclosed, and the method has been successfully extended to the configuration of perfluoroalkyl amines using RfSO2Na, complementing the established synthesis strategy of trifluoromethyl amines. Advantages of the method include good functional group tolerance, mild conditions, and inexpensive or easy-to-handle materials. Mechanistic probes indicate that the thiocarbonyl fluoride formed in situ is the key intermediate in the reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Perfluoroalkylation. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Guang-Li published the artcilePalladium-Catalyzed Reaction of 2,3-Allenols with Amines: Synthesis of [3]Dendralenes and 1,3-Dienes Containing Allylic Amino and Hydroxy Groups, HPLC of Formula: 5961-59-1, the main research area is allenol amine palladium catalyst chemoselective diastereoselective nucleophilic addition; dendralene preparation; amine allenol palladium catalyst chemoselective diastereoselective nucleophilic addition; alkadienol preparation.

Palladium-catalyzed reaction of 2,3-allenols with amines was carried out to construct conjugated polyenes with allylic amino and hydroxy groups. [Pd(π-allyl)Cl]2/P(2-furyl)3-catalyzed reaction in MeOH led to (Z)-configurated [3]dendralene derivatives and Pd(OAc)2/P(2-furyl)3-catalyzed reaction in iPrOH resulted in (1Z,3E)-1,3-diene derivatives

Advanced Synthesis & Catalysis published new progress about Alkadienes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tian, Li published the artcileCopper-catalyzed ring-opening C(sp3)-N coupling of cycloketone oxime esters: access to 1°, 2° and 3° alkyl amines, HPLC of Formula: 5961-59-1, the main research area is cycloalkanone oxime ester secondary amine copper ring opening coupling; cyanoalkyl arylamine preparation.

A novel copper-catalyzed C(sp3)-N coupling of cycloketone oxime esters with nitrogen nucleophiles were realized. All of the N-aryl/alkylanilines, anilines and benzophenone imine were employed in this protocol to produce a variety of 1°, 2° and 3° alkyl amines in one or two steps. These resultant cyano-containing alkyl amines were proved to be versatile synthetic building blocks in a variety of chem. transformations.

Chemical Communications (Cambridge, United Kingdom) published new progress about Coupling reaction. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Abudken, Ahmed M. H. published the artcileFluorinations of unsymmetrical diaryliodonium salts containing ortho-sidearms; influence of sidearm on selectivity, Synthetic Route of 151-10-0, the main research area is arene fluoroiodane fluorination; fluoroarene preparation.

Activated aromatics were reacted with two different fluoroidoane reagents in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane the unsym. diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alc. sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Organic & Biomolecular Chemistry published new progress about Aryl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Narobe, Rok published the artcilePhotocatalytic Oxidative Iodination of Electron-Rich Arenes, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is arene anthraquinone photocatalyst regioselective oxidative iodination green chem; iodoarene preparation.

A visible-light-mediated oxidative iodination of electron-rich arenes was developed. 2.5 mol% of unsubstituted anthraquinone as photocatalyst were used in combination with elementary iodine, trifluoroacetic acid and oxygen as the terminal oxidant. The iodination proceeded upon irradiation in non- or weakly-electron donating solvents (DCM, DCE and benzene) wherein a spectral window in strongly colored iodine solutions was observed at around 400 nm. The method provided good to excellent yields (up to 98%) and showed excellent regioselectivity and good functional group tolerance (triple bonds, ketone, ester, amide). Moreover, the photo-iodination was also upscaled to a 5 mmol scale (1.1 g). Mechanistic investigations by intermediate trapping and competition experiments indicate a photocatalytic arene oxidation and the subsequent reaction with iodine as a likely mechanistic pathway.

Advanced Synthesis & Catalysis published new progress about Aryl iodides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dethe, Dattatraya H. published the artcileSc(OTf)3-Catalyzed Synthesis of Symmetrical Dithioacetals and Bisarylmethanes Using Nitromethane as a Methylene Source, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is scandium catalyzed synthesis sym thioacetal arylmethane nitromethane methylene source.

Use of nitromethane as an electrophilic methylene source for the synthesis of sym. dithioacetals and bisarylmethanes has been showcased using Sc(OTf)3 as a catalyst. The procedure allows straightforward access to densely functionalized dithioacetals and bisarylmethanes under mild conditions. Addnl., the method has been applied for the synthesis of antimalarial tetra-Me mellotojaponin C and anticancer dimeric phloroglucinol derivative

Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shi, Cuiying published the artcileRoom-Temperature C-H Bromination and Iodination with Sodium Bromide and Sodium Iodide Using N-Fluorobenzenesulfonimide as an Oxidant, SDS of cas: 151-10-0, the main research area is quinoline fluorobenzenesulfonimide regioselective oxidative halogenation green chem; benzene fluorobenzenesulfonimide regioselective oxidative halogenation green chem.

A transition-metal-free electrophilic bromination and iodination of arene through C-H cleavage at room temperature was developed in excellent to quant. yields with broad arene scope and good regioselectivity, in which environment-benign and readily available sodium halides, NaBr or NaI, were employed as halogen sources in accompany with N-fluorobenzenesulfonimide (NFSI) as an oxidant. Studies was demonstrated that, in this air- and moisture-resistant scalable halogenation under mild conditions, the oxidant NFSI was reduced to dibenzenesulfonimide which usually serves as the starting material for the preparation of NFSI, rendering this facile and versatile protocol promising potentials for future applications in organic synthesis.

ChemistrySelect published new progress about Bromination, regioselective (oxidative). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem