Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.486-73-7,Isoquinoline-1-carboxylic acid,as a common compound, the synthetic route is as follows.

Isoquinoline carboxylic acid a (5.0 g, 28.9 mmol), N.O-dimethy-hydroxylamine hydrochloride (3.1 g, 31.8 mmol) EDC (6.1 g, 32 mmol), DIPEA (5.7 mL, 32 mmol) and MeCN (50 mL) were mixed together and stirred at rt overnight. The MeCN was removed under reduced pressure and the residue partitioned between water (200 mL) and EtOAc (200 mL). The phases were separated and the aqueous phase was extracted with EtOAc (2 x 50 mL). The combined organic phases were b as a colorless solid.

486-73-7, The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; GENENTECH, INC.; WO2006/69063; (2006); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

19493-45-9, 3-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Tris(dibenzylideneacetone)dipalladium (0) (0.05 g, 0.06 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (0.015 g, 0.03 mmol), cesium carbonate (0.5 g, 2.0 mmol) and 2-chloroquinoline (0.085 g, 0.52 mmol) were added sequentially to a stirred solution of N-[1-(4-amino-benzenesulfonyl)-piperidin-4-yl]-acrylamide in dry dioxane (5 ml) under a nitrogen atmosphere. The mixture was heated to 110 C. for 12 hours. After this time the mixture was cooled to room temperature, filtered through a pad of celite, the celite was washed with EtOAc (50 ml) and the filtrate was washed sequentially with citric acid (10% solution, 20 ml) and brine (20 ml). The organic layer was separated, dried (MgSO4), filtered and concentrated. The resulting residue was purified by prep HPLC to give the title compound (0.002 g, 0.5% yield) as a white solid.

19493-45-9, The synthetic route of 19493-45-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Prime, Michael; Courtney, Stephen Martin; Marston, Richard; Dominguez, Celia; Macdonald, Douglas; Wityak, John; US2012/302539; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-91-8,4-Chloroisoquinoline,as a common compound, the synthetic route is as follows.

1532-91-8, Intermediate 88 (375 mg) was dissolved in concentrated sulfuric acid (2 ml), then added with potassium nitrate (260 mg) with ice cooling and stirred for 2 hours. The reaction mixture was added with 28% aqueous ammonia (10 ml) and extracted twice with ethyl acetate (15 ml for each time). The organic layer was dried over anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (332 mg).

1532-91-8 4-Chloroisoquinoline 640974, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Yamada, Rintaro; Seto, Minoru; US2005/20623; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.27104-72-9,Methyl isoquinoline-1-carboxylate,as a common compound, the synthetic route is as follows.

A solution of methyl 1-isoquinolinecarboxylate (1.00 g, 5.34 mmol) in dry THF (30 mL) was cooled to -70 C in a dry ice/MeOH bath. To that solution was added a suspension of LiAlH4 (0.10 g, 2.67 mmol) in THF (10 mL). The resulting brown reaction mixture was stirred for 15 min followed by a quench with glacial acetic acid (1.3 mL). Once the mixture warmed to RT the aluminum salts were precipitated with a few drops 1 N NaOH. The heterogeneous mixture was filtered, and the solvent was removed under vacuum. The residue was dissolved into a small portion of CH2Cl2 and chromatographed on silica (1:1 hexanes: EtOAc, Rf = 0.79) affording 1-isoquinolinecarboxaldehyde (0.28 g, 33%) as a crystalline white solid. 1H NMR (CDCl3): 10.40 ppm (1H, s); 9.33 ppm (1H, m); 8.76 ppm (1H, d, J = 5.6 Hz); 7.91 ppm (2H, m); 7.77 ppm (2H, m). 13C NMR (CDCl3): 195.63, 149.79, 142.41, 136.85, 130.74, 130.01, 126.91, 126.31, 125.70, 125.45 ppm. IR (KBr pellet): 3033, 2844, 1703 cm-1., 27104-72-9

27104-72-9 Methyl isoquinoline-1-carboxylate 21196988, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; Nyiranshuti, Lea; Kennedy, Daniel P.; DiPasquale, Antonio G.; Rheingold, Arnold L.; Planalp, Roy P.; Polyhedron; vol. 109; (2016); p. 147 – 153;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

63006-93-9,63006-93-9, (1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 1. Preparation of a combinatorial library of substituted 2-aminomethyl-5-hydroxy-1H-indole-3-carboxylic acids esters of general formula 1.1. A mixture of 0.357 mmol of ester 2, 0.43 mmol of a secondary amine 3, and 0.43 mmol of formaldehyde in the form of formalin in 3 ml of dioxane is heated at 70-80C at stirring for 12 to 48 hours. Progress of the reaction is monitored by chromato-mass-spectrometry. Upon completion of the reaction, the reaction mass is diluted with water, the residue is filtered and recrystallized from a suitable solvent, or purified by chromatography.

As the paragraph descriping shows that 63006-93-9 is playing an increasingly important role.

Reference£º
Patent; Alla Chem, LLC.; Ivashchenko, Andrey, Alexandrovich; EP2036889; (2009); A2;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3336-43-4,1-Chloroisoquinolin-4-ol,as a common compound, the synthetic route is as follows.

The mixture of 1-chloroisoquinolin4-ol (0.5 g, 2.8 mmol) and [6-({[tert- butyl (dimethyl) silyl] oxy} methyl) pyridin-2-yl] methyl methanesulfonate (0.9 g, 2.8 mmol) in anhydrous DMF (15 mL) was treated with potassium hydroxide (0.16 g, 2.8 mmol) at rt. After 12, the mixture was partitioned between saturated aqueous NaHC03 (10 mL) and EtOAc (20 mL). The phases were separated and the aqueous layer was extracted with EtOAc (3 x 20 mL). The combined organic layers were dried (MgSO4), filtered, and concentrated. The residue was purified on silica gel (20: 1 hexane-ethyl acetate) to provide 4-{ [6-({ [tert-butyl (dimethyl) silyl] oxy} methyl) pyridin-2-yl] methoxy}-1-chloroisoquinoline as an orange oil : LRMS (ESI) m/z 416 (416 calcd for C22H27ClN202Si, M+H).

3336-43-4, As the paragraph descriping shows that 3336-43-4 is playing an increasingly important role.

Reference£º
Patent; MERCK & CO., INC.; WO2005/41971; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-06-0,7-Chloroisoquinoline,as a common compound, the synthetic route is as follows.

7-chloroisoquinoline (9 g, 55.0 mmol, 1.0 equiv)[mixture of 7-isoquinoline 3-5a and 8-isoquinoline 3-5b (a/b=3/2)]was dissolved in nitrobenzene (180 mL) and heated at 180 C. Bromine was added dropwise to this dark orange solution (3.11 ml, 60.5 mmol, 1.1 equiv.). The reaction mixture was stirred at 180 C. for 10 hours. LCMS showed that almost complete conversion. The reaction mixture was cooled to room temperature, 2M HCl in Et2O (30 mL) was added, followed by dilution with Et2O and Hexane. The precipitate was collected then taken up with EtOAc (200 mL), neutralized with saturated Na2CO3, and separated. The organic layer was dried over Na2SO4, filtered and concentrated. The crude residue was purified with silica gel chromatography (EtOAc/Hexane=0->30%) to give the title product 3-4. LRMS m/z (M+H) 242.2 found, 241.9 required., 34784-06-0

As the paragraph descriping shows that 34784-06-0 is playing an increasingly important role.

Reference£º
Patent; Arrington, Kenneth L.; Brnardic, Edward J.; Dudkin, Vadim Y.; Fraley, Mark E.; Huang, Shaei Y.; Wang, Cheng; US2007/254879; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.347146-33-2,1-Chloroisoquinolin-6-amine,as a common compound, the synthetic route is as follows.

SYNTHETIC EXAMPLE 62b 1-Chloro-6-(4-chlorobenzenesulfonylamino)isoquinoline The title compound was obtained using 6-amino-1-chloro-isoquinoline (Production Example 23b) and 4-chlorobenzenesulfonyl chloride in the same method as in Synthetic Example 1b. 1H-NMR(CDCl3) delta (ppm): 7.33(1H, brs), 7.39(1H, dd, J=2.0, 8.8 Hz), 7.44(2H, d, J=8.8 Hz), 7.50(1H, d, J=5.6 Hz), 7.58(1H, d, J=2.0 Hz), 7.81 (2H, d, J=8.8 Hz), 8.24 (1H, d, J=5.6 Hz), 8.25 (1H, d, J=8.8 Hz). FAB-MS: 353., 347146-33-2

347146-33-2 1-Chloroisoquinolin-6-amine 22674114, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Wakabayashi, Toshiaki; Funahashi, Yasuhiro; Hata, Naoko; Semba, Taro; Yamamoto, Yuji; Haneda, Toru; Owa, Takashi; Tsuruoka, Akihiko; Kamata, Junichi; Okabe, Tadashi; Takahashi, Keiko; Nara, Kazumasa; Hamaoka, Shinichi; Ueda, Norihiro; US2004/18192; (2004); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

6624-49-3, Isoquinoline-3-carboxylic acid (500 mg, 2.89 mmol), glycine methyl ester hydrochloride (363 mg, 2.89 mmol, 1 eq), PyBOP (1.65 g, 3.18 mmol, 1.2 eq) and Et3N (400 mu, 2.89 mmol, 1 eq) were dissolved in the anhydrous DMF (10 mL) and stirred at room temperature for 24h. Upon completion of the reaction the DMF was evaporated in vacuo and the resultant residue was suspended in CH2CI2 (20 mL) and washed with H20 (2 x 10 mL). The organic phase was dried over MgS04, filtered and subjected to the column chromatography (eluent system: cHex/EtOAc). The obtained product was dissolved in a mixture of THF/H20 (1 : 1, 10 mL) and treated with LiOH H20 (600 mg, 14.45 mmol, 5 eq). The reaction was stirred at room temperature for 12h. The TFIF was evaporated in vacuo and the remaining aqueous solution was neutralized with cone. HCl. The precipitate was collected by filtration and dried in vacuo to yield the desired product (266 mg, 1.16 mmol, 40percent). 1H NMR (400 MHz, DMSO-i) delta = 9.42 (s, 1 H, H6), 9.14 (t, J=6.0 Hz, 1 H, H), 8.58 (si H, H5), 8.27 (d, J=8.0 Hz, 1 H, H3), 8.22 (d, J=8.0 Hz, 1 H, H4) 7.90 (ddd, J=8.0, 7.0, 1.0 Hz, 1 H, H2) 7.83 (ddd, J=8.0, 7.0, 1.0 Hz, 1 H, HI) 4.05 (d, J=6.0 Hz, 2 H, H7 , H7//)ppm. 13C NMR (101 MHz, DMSO-i) delta = 171.7, 164.9, 152.1, 143.8, 135.8, 131.9, 129.8, 129.7, 128.5, 128.3, 120.3, 41.6 ppm. Mp = 208-210 ¡ãC (223-224 ¡ãC)21. HRMS (ESI-TOF) calcd for Ci2Hi0N2NaO3 [M+Na+] : 253.0584, found: 253.0595, FT-IR vmax (neat): 3378, 1733, 1631, 1531, 1233, 766 cm”1.

The synthetic route of 6624-49-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ISIS INNOVATION LIMITED; SCHOFIELD, Christopher Joseph; RYDZIK, Anna; MCDONOUGH, Michael; CHOWDHURY, Rasheduzzaman; WO2015/92412; (2015); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1041423-28-2, 3-Chloro-6-fluoroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 4: 16.5 g of (cis-4-hydroxy-cyclohexyl)-carbamic acid tert-butyl ester were dissolved in 210 ml of diglyme and treated with 4.1g 50% NaH under nitrogen. The resulting mixture was stirred for 1 h at room temperature, then 14.8 g of the product from Step 3 were added. The mixture was allowed to stir for 1 day at room temperature, then 100 ml of toluene were added and the resulting mixture was washed with water 3 times. The organic phases were collected and the solvent was removed in vacuo., 1041423-28-2

As the paragraph descriping shows that 1041423-28-2 is playing an increasingly important role.

Reference£º
Patent; SANOFI-AVENTIS; WO2008/77554; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem