With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.34784-06-0,7-Chloroisoquinoline,as a common compound, the synthetic route is as follows.
7-chloroisoquinoline (9 g, 55.0 mmol, 1.0 equiv)[mixture of 7-isoquinoline 3-5a and 8-isoquinoline 3-5b (a/b=3/2)]was dissolved in nitrobenzene (180 mL) and heated at 180 C. Bromine was added dropwise to this dark orange solution (3.11 ml, 60.5 mmol, 1.1 equiv.). The reaction mixture was stirred at 180 C. for 10 hours. LCMS showed that almost complete conversion. The reaction mixture was cooled to room temperature, 2M HCl in Et2O (30 mL) was added, followed by dilution with Et2O and Hexane. The precipitate was collected then taken up with EtOAc (200 mL), neutralized with saturated Na2CO3, and separated. The organic layer was dried over Na2SO4, filtered and concentrated. The crude residue was purified with silica gel chromatography (EtOAc/Hexane=0->30%) to give the title product 3-4. LRMS m/z (M+H) 242.2 found, 241.9 required., 34784-06-0
As the paragraph descriping shows that 34784-06-0 is playing an increasingly important role.
Reference£º
Patent; Arrington, Kenneth L.; Brnardic, Edward J.; Dudkin, Vadim Y.; Fraley, Mark E.; Huang, Shaei Y.; Wang, Cheng; US2007/254879; (2007); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem