With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1532-91-8,4-Chloroisoquinoline,as a common compound, the synthetic route is as follows.
1532-91-8, Intermediate 88 (375 mg) was dissolved in concentrated sulfuric acid (2 ml), then added with potassium nitrate (260 mg) with ice cooling and stirred for 2 hours. The reaction mixture was added with 28% aqueous ammonia (10 ml) and extracted twice with ethyl acetate (15 ml for each time). The organic layer was dried over anhydrous sodium sulfate, and then the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (n-hexane:ethyl acetate=1:1) to obtain the title compound (332 mg).
1532-91-8 4-Chloroisoquinoline 640974, aisoquinoline compound, is more and more widely used in various fields.
Reference£º
Patent; Yamada, Rintaro; Seto, Minoru; US2005/20623; (2005); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem