Tag: M.W:100-200

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4456-77-3,Isoquinoline-1,3(2H,4H)-dione,as a common compound, the synthetic route is as follows.,4456-77-3

EXAMPLE IX 1,3(2H,4H)-Dioxoisoquinoline-4-carboxanilide A solution containing 1,3(2H,4H)-dioxoisoquinoline (4.0 g., 0.025 mole), triethylamine (2.6 g., 0.026 mole) and phenylisocyanate (3.1 g., 0.026 mole), in 100 ml. of tetrahydrofuran was refluxed for 2 hours. The solution was then poured into an excess of ice water containing 5 ml. of hydrochloric acid. The resulting precipitate was collected by filtration, washed with water, dried and recrystallized from acetic acid, to give 1,3(2H,4H)-dioxoisoquinoline-4-carboxanilide, m.p. 249-250 C. Anal. Calc’d for C16 H11 N2 O3: C, 68.56; H, 4.32; N, 10.00. Found: C, 68.86; H, 4.37; N, 9.80.

The synthetic route of 4456-77-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US3998954; (1976); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1532-91-8, 4-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1532-91-8

General procedure: 2 mol% Pd(OAc)2/3 mol% Nixantphos, anhydrous DMF (1.0 ml) were added to an oven-dried 10 ml reaction vial equipped with a stir bar, the mixture was stirred at 45 C under an argon atmosphere for 1h to be a dark brown solution. 1 mol% CuI/1.1 mol% Nixantphos, anhydrous DMF (1.0 ml) were added to an oven-dried 10 ml reaction vial equipped with a stir bar, the mixture was stirred at 60 C under an argon atmosphere for 2h to be a colorless transparent solution. The amount of catalyst and solvent should scaled up by the number of reactions. Benzoxazoles (0.25 mmol), aryl chlorides (0.3 mmol) and K3PO4*7H2O (42.3 mg, 0.125 mmol, 0.5 equiv) were added to an oven-dried 10 ml reaction vial equipped with a stir bar. A stock solution of Pd(OAc)2/Nixantphos and CuI/Nixantphos in 1 ml of dry DMF was taken up by syringe and added to the reaction vial. The reaction vial filled with argon was then sealed with a septum. The reaction mixture was stirred for12 h or 24 h at 120 C, quenched with two drops of H2O, diluted with 3 mL of ethyl acetate, and filtered over a pad of MgSO4 and silica. The pad was rinsed with additional ethyl acetate, and the solution was concentrated in vacuo. The crude material was loaded onto a silica gel column and purified by flash chromatography.

The synthetic route of 1532-91-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Zheng, Ling-Li; Yin, Bo; Tian, Xing-Chuan; Yuan, Ming-Yong; Li, Xiao-Huan; Gao, Feng; Tetrahedron Letters; vol. 60; 51; (2019);,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1198-30-7,1-Isoquinolinecarbonitrile,as a common compound, the synthetic route is as follows.

1198-30-7, Preparation 149 N’-Hydroxy-1-isoquinolinecarboximidamide The title compound was obtained as a white solid from 1-cyanoisoquinoline using a similar method to that described in Preparation 110. 1H NMR (300 MHz, D6-DMSO) delta 5.94 (s, 2H), 7.67 (dd, 1H), 7.78 (dd, 1H), 7.86 (d, 1H), 7.99 (d, 1H), 8.52 (d, 1H), 9.07 (d, 1H), 10.11 (s, 1H).

As the paragraph descriping shows that 1198-30-7 is playing an increasingly important role.

Reference£º
Patent; Bailey, Simon; Fish, Paul Vincent; James, Kim; Whitlock, Gavin Alistar; US2003/69291; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

119-65-3, Isoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a stirred solution of isoquinoline (24 g, 186 mmol) in AcOH (50 mL) was added NBS (36.2 g, 204.6 mmol) at RT and the reaction mixture was heated to 100 C. overnight. Then it was cooled to RT and concentrated under reduced pressure. The crude product obtained was purified by flash column chromatography (5% EtOAc:Hexanes) to furnish the title compound (9.2 g, 23.8%) as an oil.

119-65-3, The synthetic route of 119-65-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LUPIN LIMITED; KULKARNI, Sanjeev Anant; MADAN, Sachin; JANA, Nirmal Kumar; TALE, Prashant Vitthalrao; CHEEMALA, Narasimha Murthy; MAHANGARE, Sachin Jaysing; VIDHATE, Prashant Popatrao; KULKARNI, Chaitanya Prabhakar; PATEL, Sapana Suresh; PATIL, Amolsing Dattu; ZADE, Seema Prabhakar; SHINDE, Rohan Mahadev; PALLE, Venkata P.; KAMBOJ, Rajender Kumar; US2013/178457; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22246-04-4,7-Methoxy-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.

To a solution of 31.25g(0.29 mol) of sodium hydride in 50 mL of dry N,N-dimethylformamide a solution of 11.50 g (65.0 mmol) 7-methoxy-3,4-dihydroisoquinolin-1(2H)-onein 30 mL of N,N-dimethylformamideand 10.15g (71.5mmol) iodomethane was added dropwise under ice-cooling. The reaction mixture was stirred at room temperature (20C) for 1.5 hrs. The reaction was quenched with 480ml water,extracted with ethyl acetate (100 mL x 3), washed with brine,and dried over Na2SO4.The organic phase was evaporated under reduced pressure togivecrude oil.The residue was purified withcolumn chromatography (eluent: ethyl acetate : hexane = 1 : 5) to afford yellowoil(11.17 g, 58.5mmol, 90% yield)., 22246-04-4

As the paragraph descriping shows that 22246-04-4 is playing an increasingly important role.

Reference£º
Article; Dou, Fei; Cao, Xudong; Jing, Peng; Wu, Chunyan; Zhang, Yuxin; Chen, Yin; Zhang, Guisen; Bioorganic and Medicinal Chemistry Letters; vol. 29; 12; (2019); p. 1492 – 1496;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

19493-45-9, 3-Chloroisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound A1 (5 mmol) and compound B1 (6 mmol) were weighed into a three-neck flask and Pd(pph3)4 (0.15 mmol) was added as a catalyst.K2CO3 (16 mmol) was added, vacuum was applied to the double-row tubes, nitrogen-filled vacuum was applied, and the mixture was recycled three times. Finally, the reaction system was protected with nitrogen.Add 15 mL each of dimethyl ether and water with a syringe and heat to reflux. The reaction was refluxed for 24 h and cooled to room temperature. After vortexing, the column was purified and product 11 was obtained.

19493-45-9, The synthetic route of 19493-45-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Shanghai Hehui Optoelectric Co., Ltd.; Liang Hua; (13 pag.)CN107586308; (2018); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.80278-67-7,Isoquinoline-5-carbaldehyde,as a common compound, the synthetic route is as follows.

80278-67-7, General procedure: To a dried two-neck round-bottom flask containing DMF (0.7mL for 1.10mmol of starting material) chilled in an ice bath, POCl3 (1.95 equiv) was added slowly. After stirring for 20min, a solution of an indole derivative (1.0 equiv) in DMF (3mL for 1.10mmol of starting material) was added dropwise. The reaction was allowed to warm to room temperature and allowed to stir for 1.5h. The reaction was quenched by adding ice followed by 1N NaOH (40mL) dropwise in an ice bath. The crude mixture was allowed to stand at room temperature and the precipitate formed was filtered to afford the 3-formyl-indole derivative product.

80278-67-7 Isoquinoline-5-carbaldehyde 7016853, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Article; See, Cheng Shang; Kitagawa, Mayumi; Liao, Pei-Ju; Lee, Kyung Hee; Wong, Jasmine; Lee, Sang Hyun; Dymock, Brian W.; European Journal of Medicinal Chemistry; vol. 156; (2018); p. 344 – 367;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

18881-17-9, (S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

18881-17-9, The experimental procedure used for this reaction was adapted from the literature.15 To a solution of (S)-3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 4 (1.42 g, 8.70 mmol) in dioxane (20 mL) and water (10 mL) at 0 C, was added dropwise a solution of potassium hydrogen carbonate (4.30 g, 41.0 mmol) in water (10 mL) over 15 min followed by addition of CbzCl (1.63 g,9.50 mmol). The mixture was stirred for 1.5 h at 0 C and then atambient temperature for a further 1.5 hours. Completion of the reaction was monitored by TLC in hexane:ethyl acetate (60:40,Rf = 0.32). The solvent was removed under reduced pressure to afford the crude compound (S)-benzyl 3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-2-carboxylate 5, which was purified by column chromatography using 0-40% ethyl acetate in hexane as the eluent to yield pure compound 5 as an oil. Yield1.85 g (74%). [alpha]D20 (c = 0.35, in CH2Cl2). IR numax/cm-1 = 3418, 3030,2945, 1676, 1415, 1345, 1219, 1119, 1027 and 741. NMR spectrumare reported for a mixture of two rotamers.20.21 1H NMR(400 MHz, CDCl3) delta = 2.83 (brd, 1H, J = 15.15 Hz), 3.04 (dd, 1H,J=6.08, 15.95 Hz) , 3.36-3.63 (m, 2H), 4.29-4.47 (m, 1H), 4.48-4.64(m, 1H), 4.70-4.95 (m, 1H), 5.19 (s, 2H) and 7.01-7.43 (m, 9H). TheOH proton was not observed. 13C NMR (100 MHz, CDCl3) delta =156.9, 136.4, 132.8, 132.5, 129.8, 128.8, 128.5, 128.0, 127.9, 127.8,127.0, 126.4, 126.0, 125.9, 67.4, 63.3, 52.3, 43.7 and 29.8.HRESI MS:m/z = 320.2159 [M+ Na]+ (calcd. for C18H19NNaO3 = 320.1257).

As the paragraph descriping shows that 18881-17-9 is playing an increasingly important role.

Reference£º
Article; Kawthekar, Rahul B.; Peters, Byron K.; Govender, Thavendran; Kruger, Hendrik G.; Maguire, Glenn E.M.; South African Journal of Chemistry; vol. 63; (2010); p. 195 – 198;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.119-65-3,Isoquinoline,as a common compound, the synthetic route is as follows.

General procedure: To an 8 mL dram vial was added iodobenzene diacetate (0.6 mmol, 1.5 equiv), and heteroarene(0.4 mmol, 1 eq.), anhydrous dichloroethane (1 mL), then chloride source (5 equiv). The solutionwas allowed to stir (1000 rpm) at 50 C for the indicated amount of time. After which the solutionwas washed with saturated sodium bicarbonate, followed by saturated sodium thiosulfate andconcentrated. The crude mixture was then purified by column chromatography.

119-65-3, The synthetic route of 119-65-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

486-73-7, Isoquinoline-1-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(Step 1) Synthesis of methyl (3-chloro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate In DMF (15 ml) were dissolved 1-isoquinolinecarboxylic acid (1.00 g, 5.77 mmol), methyl 4-amino-3-chlorophenylacetate (1.23 g, 6.16 mmol), HOBt (0.16 g, 1.15 mmol), and DMAP (0.14 g, 1.15 mmol). To the resulting solution was added EDC HCl (1.33 g, 6.93 mmol), followed by stirring at room temperature for 14 hours. The reaction mixture was poured into water (40 ml). The crystals precipitated were collected by filtration under reduced pressure, washed with water and ether, dried under reduced pressure to give methyl (3-chloro-4-((1-isoquinolinylcarbonyl)amino)phenyl)acetate (1.14 g, 56%) as a brown solid. 1H-NMR (CDCl3) delta: 3.62 (s, 2H), 3.72 (s, 3H), 7.29 (m, 1H), 7.40 (d, J=1.9Hz, 1H), 7.71-7.78 (m, 2H), 7.88-7.91 (m, 2H), 8.58 (d, J=5.4Hz, 1H), 8.65 (d, J=8.3Hz, 1H), 9.71 (m, 1H), 11.02 (m, 1H). MS (ESI) m/z 355 (M++1).

486-73-7, The synthetic route of 486-73-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; EP1346982; (2003); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem