With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.4456-77-3,Isoquinoline-1,3(2H,4H)-dione,as a common compound, the synthetic route is as follows.,4456-77-3
EXAMPLE IX 1,3(2H,4H)-Dioxoisoquinoline-4-carboxanilide A solution containing 1,3(2H,4H)-dioxoisoquinoline (4.0 g., 0.025 mole), triethylamine (2.6 g., 0.026 mole) and phenylisocyanate (3.1 g., 0.026 mole), in 100 ml. of tetrahydrofuran was refluxed for 2 hours. The solution was then poured into an excess of ice water containing 5 ml. of hydrochloric acid. The resulting precipitate was collected by filtration, washed with water, dried and recrystallized from acetic acid, to give 1,3(2H,4H)-dioxoisoquinoline-4-carboxanilide, m.p. 249-250 C. Anal. Calc’d for C16 H11 N2 O3: C, 68.56; H, 4.32; N, 10.00. Found: C, 68.86; H, 4.37; N, 9.80.
The synthetic route of 4456-77-3 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; Pfizer Inc.; US3998954; (1976); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem