With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22246-04-4,7-Methoxy-3,4-dihydroisoquinolin-1(2H)-one,as a common compound, the synthetic route is as follows.
To a solution of 31.25g(0.29 mol) of sodium hydride in 50 mL of dry N,N-dimethylformamide a solution of 11.50 g (65.0 mmol) 7-methoxy-3,4-dihydroisoquinolin-1(2H)-onein 30 mL of N,N-dimethylformamideand 10.15g (71.5mmol) iodomethane was added dropwise under ice-cooling. The reaction mixture was stirred at room temperature (20C) for 1.5 hrs. The reaction was quenched with 480ml water,extracted with ethyl acetate (100 mL x 3), washed with brine,and dried over Na2SO4.The organic phase was evaporated under reduced pressure togivecrude oil.The residue was purified withcolumn chromatography (eluent: ethyl acetate : hexane = 1 : 5) to afford yellowoil(11.17 g, 58.5mmol, 90% yield)., 22246-04-4
As the paragraph descriping shows that 22246-04-4 is playing an increasingly important role.
Reference£º
Article; Dou, Fei; Cao, Xudong; Jing, Peng; Wu, Chunyan; Zhang, Yuxin; Chen, Yin; Zhang, Guisen; Bioorganic and Medicinal Chemistry Letters; vol. 29; 12; (2019); p. 1492 – 1496;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem