Tag: M.W:100-200

3336-43-4, 1-Chloroisoquinolin-4-ol is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step 1: Preparation of 1-chloro-4-methoxyisoquinoline To a solution of 1-chloroisoquinolin-4-ol (5.0 g, 27.8 mmol) in acetonitrile (50 mL) was added TMS-diazomethane (12.73 g, 111.2 mmol) at 0 C. The reaction mixture was allowed to come to room temperature and stirred for 2 h. Solvent was evaporated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography to get 1-chloro-4-methoxyisoquinoline (2.5 g, 46.4%) as off-white solid. 1H NMR (400 MHz, CD3OD): delta ppm 8.29-8.17 (m, 2H), 7.97 (s, 1H), 7.91-7.82 (m, 2H), 4.05 (s, 3H); MS: MS m/z 194.7 (M++1).

3336-43-4, As the paragraph descriping shows that 3336-43-4 is playing an increasingly important role.

Reference£º
Patent; Bristol-Myers Squibb Company; Hiebert, Sheldon; Rajamani, Ramkumar; Sun, Li-Qiang; Mull, Eric; Gillis, Eric P.; Bowsher, Michael S.; Zhao, Qian; Meanwell, Nicholas A.; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Babu, P. V. K. Suresh; Scola, Paul Michael; US2013/115190; (2013); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.216099-46-6,6-Aminoisoquinolin-1-ol,as a common compound, the synthetic route is as follows.

Example 13Synthesis of 1-benzyl-3-(1-oxo-1,2-dihydro-isoquinolin-6-yl)-urea. Method 4 6-Amino-2H-isoquinolin-1-one (0.2 mmol, 39 mg) and benzyl isocyanate (0.2 mmol, 27 mg) were dissolved in 1 mL DMA. The mixture was allowed to stir at 60 C. overnight. The product was obtained by HPLC purification. MS (M+1) 294., 216099-46-6

The synthetic route of 216099-46-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Young, Erick Richard; Liu, Weimin; Prokopowicz, Anthony S.; Schlyer, Sabine K.; Shih, Cheng-Kon; Snow, Roger John; Bosanac, Todd; Ginn, John David; Hickey, Eugene Richard; Kirrane, Thomas Martin; Turner, Michael Robert; Wu, Frank; US2008/161297; (2008); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Preparation 69Methyl 3-({Gamma(1 R)-1 -(2,4-difluorophenyl)propyll(isoquinolin-3-ylcarbonyl)amino} methvDbenzoate lsoquinoline-3-carboxylic acid (32.6mg, 0.188mmol) was dissolved in dichloromethane (4ml_) and HBTU (77.4mg, 0.204mmol) was added followed by triethylamine (65.7muIota_, 0.471 mmol). The resulting solution was allowed to stir at room temperature for 10mins prior to the addition of amine from preparation 4 (50mg, 0.16mmol). The resulting reaction mixture was then allowed to stir at room temperature over night. The crude mixture was diluted with dichloromethane (20ml_) and washed with water (20ml_), the aqueous phase was then re-extracted with dichloromethane (20ml_) and the combined organics dried (MgS04) and concentrated in vacuo to give the title compound as a clear oil (74mg, 100percent) which was used . LCMS Rt 1.77mins, (ES APCI) m/z 497 [M+Na]+ (Analysis System 4)., 6624-49-3

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Patent; PFIZER LIMITED; GLOSSOP, Paul Alan; PALMER, Michael John; ANDREWS, Mark David; WO2012/120398; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6624-49-3,Isoquinoline-3-carboxylic acid,as a common compound, the synthetic route is as follows.

6624-49-3, General procedure: To a solution of carboxylic acid (3 equiv) in DMF was added N-(3-dimethylaminopropyl)-N?-ethylcarbodiimide hydrochloride (EDCI, 3 equiv), hydroxybenzotriazole (HOBt, 3 equiv), molecular sieves, and Et3N (5 equiv) on an ice-water bath under N2 protection. After 15min, a solution of 17 (1 equiv) in DMF was added. The reaction mixture was stirred overnight at room temperature. The mixture was filtered through celite and the filtrate was concentrated in vacuum to remove DMF. The residue was dissolved in CH3OH and added potassium carbonate (2 equiv). The resulting mixture was stirred overnight at room temperature. After concentration, the residue was partitioned between water and CH2Cl2.The water layer was extracted with CH2Cl2, the combined extract was washed with brine,and dried over Na2SO4. After concentration, the residue was purified by silica gel column with a CH2Cl2/CH3OH (50:1) (1percent NH3H2O) solvent system as eluent to give the target product.

As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.

Reference£º
Article; Zhang, Yan; Elbegdorj, Orgil; Yuan, Yunyun; Beletskaya, Irina O.; Selley, Dana E.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 13; (2013); p. 3719 – 3722;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.106778-43-2,6-Isoquinolinecarboxylic Acid,as a common compound, the synthetic route is as follows.

Benzyl-N-(2-amino-2-phenyl-ethyl)carbamate (2.00 g, 7.40 mmol)Soluble in DMF (10.0mL),Add benzotriazole-N,N,N’,N’-tetramethylurea hexafluorophosphate (2.07 g, 8.14 mmol),Isoquinoline-6-carboxylic acid (1.28 g, 7.40 mmol)And N,N-diisopropylethylamine (3.38 g, 29.6 mmol),After stirring for 1 hour, it was extracted with ethyl acetate and water.The solvent was distilled off under reduced pressure.Purification by column chromatography gave benzyl-N-((S)-2-(isoquinolin-6-carboxamide)-2-phenyl-ethyl)carbamate (1.98 g, 4.21 mmol, yield 57 %).

106778-43-2, As the paragraph descriping shows that 106778-43-2 is playing an increasingly important role.

Reference£º
Patent; Chengdu Xiandao Pharmaceutical Development Co., Ltd.; Li Jin; Zhang Dengyou; Feng Jingchao; Liao Wei; Lin Li; Li Si; Chen Wei; (12 pag.)CN109134433; (2019); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.18881-17-9,(S)-(1,2,3,4-Tetrahydroisoquinolin-3-yl)methanol,as a common compound, the synthetic route is as follows.,18881-17-9

Compound 2 (5.3 g, 16.47 mmol) and (S)-(1,2,3,4-tetrahydroisoquinolin-3-yl)methanol (2.96 g, 18.12 mmol) were dissolved in DCM (47.1 mL). The reactionmixture was cooled to 0 oc and TEA (3.44 mL, 24.71 mmol) was added dropwise underAr. The reaction mixture was then warmed to rt and was stirred overnight. The solutionwas concentrated and the crude product was purified by silica gel chromatography(EtOAc/hexanes, gradient, 0% to 80%) to obtain compound 3 (7.22 g, 16.10 mmol, 98% yield). LCMS = 5.482 min (8 min method). Mass observed (ESI+): 449.25 (M+H).

The synthetic route of 18881-17-9 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; IMMUNOGEN, INC.; MILLER, Michael, Louis; SHIZUKA, Manami; (163 pag.)WO2018/195243; (2018); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

1196-38-9, 3,4-Dihydroisoquinolin-1(2H)-one is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

c 7-nitro-1,2,3,4-tetrahydroisoquinolin-1-one To a cold solution consisting of potassium nitrate (8.2 g, 81.6 mmol) in sulfuric acid (40 mL) was added 1,2,3,4-tetrahydroisoquinolin-1-one (10 g, 68mmol) dropwise over a period of five minutes. The reaction mixture was stirred overnight at room temperature and then poured into ice. The solution was filtered. After washing with water several times, the solid was dried to yield the title compound (9.85 g, 76%).

1196-38-9, As the paragraph descriping shows that 1196-38-9 is playing an increasingly important role.

Reference£º
Patent; Smithkline Beecham Corporation; US5602145; (1997); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

90806-58-9, 5-Methoxyisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,90806-58-9

Step 2: Synthesis of 1-amino-5-hydroxyisoquinoline monohydrobromide: 900 mg (5.66 mmol) of 5-methoxyisoquinoline was dissolved in 20 ml of xylene. 4.26 ml (28.3 mmol) of N,N,N’,N’-tetramethylenediamine and 1.17 g (30.0 mmol) of sodium amide were added to the obtained solution, and they were stirred at 140C for 1 hour. After the treatment with ethyl acetate as the extraction solvent in an ordinary manner, 10 ml of hydrobromic acid was added to the obtained crude product and they were heated under reflux for 6 hours. The solvent was evaporated to obtain the title compound. Yield: 240 mg (1.0 mmol)

90806-58-9 5-Methoxyisoquinoline 13754283, aisoquinoline compound, is more and more widely used in various fields.

Reference£º
Patent; Ajinomoto Co., Inc.; EP1065200; (2001); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.23687-26-5,6-Aminoisoquinoline,as a common compound, the synthetic route is as follows.

EXAMPLE II N-(2-Hydroxyethyl)-N’-(isoquinolin-6-yl)-N-[4-[2-(methoxycarbonyl)ethyl]phenyl]-urea To 7.2 g of imidazole and 10.1 g of N,N’-carbonyldiimidazole in 100 ml of dimethylformamide are added dropwise, at a temperature of 0¡ã to 10¡ã C., 9.0 g of 6-aminoisoquinoline in 70 ml of dimethylformamide. After 2 hours stirring at ambient temperature, 15.3 g of N-(2-hydroxyethyl)-4-[2-(methoxycarbonyl)ethyl]aniline in 20 ml of dimethylformamide are added dropwise and the mixture is stirred for 21/2 days at ambient temperature. The mixture is diluted with 750 ml of ethyl acetate and extracted twice with water and saturated saline solution. The organic phase is separated off, dried and evaporated down. The residue is purified by chromatography over a silica gel column using ethyl acetate/methylene chloride/methanol=70:30:10. Yield: 4.8 g (19percent of theory), Rf value: 0.48 (silica gel; methylene chloride/methanol/ethyl acetate=20:1:1), 23687-26-5

The synthetic route of 23687-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Karl Thomae GmbH; US5519036; (1996); A;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem

23687-26-5, 6-Aminoisoquinoline is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To (S)-3-[(tert-butoxycarbonyl)amino)]-2-(4-{[(2,4-dimethylbenzoyl) oxy]methyl}phenyl)propanoic acid (8) (2.3 g, 5.5 mmol) in DMF (33 mL) cooled to 0 ¡ãC was added 6-aminoisoquinoline (1.0 g, 7.1 mmol) and 2,4,6-trimethylpyridine (947 muL, 7.1 mmol). After 10 min at 0 ¡ãC, a solution of 2,2,2-trichloro-1,1-dimethylethyl chloroformate (1.7 g, 7.1 mmol) in DMF (8.6 mL) was added and the reaction stirred at 0 ¡ãC for 2 h. The mixture was poured into NaHCO3 (sat.)/EtOAc and extracted with EtOAc. The organic layers were then washed with NaCl (sat.), dried (Na2SO4) filtered and evaporated. Column chromatography (70percent EtOAc/hexanes) gave pure (S)-4-{3-[(tert-butoxycarbonyl) amino]-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl}benzyl 2,4-dimethylbenzoate (9) (1.93 g, 63percent, 98percent ee) as a off-white solid. Recrystallization from EtOAc/hexanes gave 9 (1.43 g, 47percent, 99.7percent ee, S,SWhelk-01) as a off-white crystalline solid. Mp 155-156 ¡ãC. IR (ATR): 1713, 1644, 1527 cm-1. 1H NMR (500 MHz, DMSO-d6): delta = 9.14 (s, 1H), 8.39 (d, J = 5.7 Hz, 1H), 8.38 (s, 1H), 8.02 (d, J = 8.7 Hz, 1H), 7.75 (d, J = 7.9 Hz, 1H), 7.69- 7.66 (m, 2 H), 7.43 (s, 4 H), 7.11 (s, 1H), 7.07 (d, J = 8.4 Hz, 1H), 7.02 (br t, J = 5.4 Hz, 1H), 5.25 (s, 2 H), 4.13-4.10 (m, 1H), 3.58-3.53 (m, 1H), 3.34-3.30 (m, 1H), 2.49 (s, 3 H), 2.29 (s, 3 H), 1.32 (s, 9 H). 13C NMR (125 MHz, DMSO-d6): delta = 171.0, 166.4, 155.8, 151.5, 143.2, 142.4, 140.4, 139.5, 137.8, 136.1, 135.2, 132.3, 130.4, 128.5, 128.1, 128.0, 126.6, 126.1, 125.0, 121.0, 120.0, 113.1, 77.8, 65.6, 51.7, 42.9, 28.2, 21.2, 20.8. LC-MS (ES+): m/z = 554 [M + 1]+, 576 [M + 23]+. Anal Calcd for C33H35N3O5: C, 71.59; H, 6.37; N, 7.59. Found: C, 71.54; H, 6.51; N, 7.58.

23687-26-5, The synthetic route of 23687-26-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Delong, Mitchell A.; Sturdivant, Jill M.; Synthesis; vol. 51; 4; (2019); p. 953 – 959;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem