6624-49-3, Isoquinoline-3-carboxylic acid is a isoquinoline compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation 69Methyl 3-({Gamma(1 R)-1 -(2,4-difluorophenyl)propyll(isoquinolin-3-ylcarbonyl)amino} methvDbenzoate lsoquinoline-3-carboxylic acid (32.6mg, 0.188mmol) was dissolved in dichloromethane (4ml_) and HBTU (77.4mg, 0.204mmol) was added followed by triethylamine (65.7muIota_, 0.471 mmol). The resulting solution was allowed to stir at room temperature for 10mins prior to the addition of amine from preparation 4 (50mg, 0.16mmol). The resulting reaction mixture was then allowed to stir at room temperature over night. The crude mixture was diluted with dichloromethane (20ml_) and washed with water (20ml_), the aqueous phase was then re-extracted with dichloromethane (20ml_) and the combined organics dried (MgS04) and concentrated in vacuo to give the title compound as a clear oil (74mg, 100percent) which was used . LCMS Rt 1.77mins, (ES APCI) m/z 497 [M+Na]+ (Analysis System 4)., 6624-49-3
As the paragraph descriping shows that 6624-49-3 is playing an increasingly important role.
Reference£º
Patent; PFIZER LIMITED; GLOSSOP, Paul Alan; PALMER, Michael John; ANDREWS, Mark David; WO2012/120398; (2012); A1;,
Isoquinoline – Wikipedia
Isoquinoline | C9H7N – PubChem