Tag: M.W=150-200

Maddila, Suresh published the artcileMicrowave-Assisted Multicomponent Reaction: A Green and Catalyst-Free Method for the Synthesis of Poly-Functionalized 1,4-Dihydropyridines, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is benzaldehyde aniline malononitrile dimethylacetylenedicarboxylate multicomponent reaction microwave irradiation; dimethyl phenyl phenyldihydropyridinedicarboxylate preparation green chem.

A facile and an efficient procedure for the synthesis of poly-substituted 1,4-dihydropyridine derivatives under catalyst-free conditions was established by a one-pot multi-component reaction in EtOH solvent under microwave irradiation (150 W). The remarkable benefits of this approach were: simple operation, non-toxic, short reaction time (< 5 min), excellent yields (93-98%), no column chromatog., clean reaction profile and environmentally friendly reaction. ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Calva-Estrada, S. J. published the artcileThermal properties and volatile compounds profile of commercial dark-chocolates from different genotypes of cocoa beans (Theobroma cacao L.) from Latin America, Name: 5-Methyl-2-phenylhex-2-enal, the main research area is Theobroma cacao thermal property volatile compound dark chocolate genotype; 2,3-Butanediol (PubChem CID 262); 2-Methylpropanoic acid (PubChem CID 6590); 2-Nonanone (PubChem CID 13187); 2-Phenylethyl acetate (PubChem CID 7654); 2-Phenylethyl alcohol (PubChem CID 6054); 3-Methyl-butanal (PubChem CID 11552); Benzaldehyde (PubChem CID 240); Chemometrics; Differential scanning calorimetry; Furfural (PubChem CID 7362); Hierarchical cluster analysis heatmap; Polymorphism; Principal component analysis; Tetramethylpyrazine (PubChem CID 14296); Trimethylpyrazine (PubChem CID 26808).

There is a growing interest in the identification of chemometric markers that allow the distinction and authentication of dark-chocolates according to their cocoa geog. origin and/or genotype. However, samples derived from Latin American cocoa, including specimens from North and South America, have not been studied in this context. An exploration of the melting behavior, fat composition, bioactive content, and volatile profile of com. darkchocolates was conducted to identify possible patterns related to the genotype and/or origin of cocoa from Latin America. The melting properties were evaluated by DSC and related to fat content and fatty acids profile. Total polyphenol, anthocyanin, methylxanthine, and catechin content were analyzed. Finally, the volatile compounds were extracted and identified by HS-SPME/GC-MS and were analyzed through Principal Component Anal. (PCA) and the Hierarchical Cluster Anal. Heatmap (HCA Heatmap). The fatty acids profile showed a relationship with the melting properties of dark chocolate. The samples exhibited two glass-transition temperatures (Tg) at 19°C and 25.5°C, possibly related to traces of unstable polymorphic forms of monounsaturated triacylglycerides. The anal. of bioactive compounds demonstrated great variability among samples independent of the cocoa origin, genotype, and content. The PCA and HCA Heatmaps allowed discriminating against the chocolates in relation to the cocoa origin and genotype. Compounds like tetramethylpyrazine, trimethylpyrazine, benzaldehyde, and furfural could be considered as dark-chocolate aroma markers derived from Latin American cocoas (North American region). The 2-phenylethyl alc., 2-methylpropanoic acid, 2,3-butanediol, 2-nonanone, and limonene for derived from South America. And the 2-phenylethyl acetate, 3-methyl-butanal, and cinnamaldehyde could allow to distinguishing between regional genotypes.

Food Research International published new progress about Anthocyanins Role: ANT (Analyte), ANST (Analytical Study). 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Name: 5-Methyl-2-phenylhex-2-enal.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Abdelhamid, Yusra published the artcileIsothiourea-Catalyzed [2+2] Cycloaddition of C(1)-Ammonium Enolates and N-Alkyl Isatins, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is beta hydroxyamide preparation diastereoselective enantioselective; alkyl isatin anhydride ammonium enolate cycloaddition ring opening isothiourea.

Enantioselective [2+2] cycloaddition of C(1)-ammonium enolates generated catalytically using the isothiourea HyperBTM with N-alkyl isatins gives spirocyclic β-lactones. In situ ring-opening with an amine nucleophile generates isolable highly enantioenriched products I (R1 = H, 6-Cl, 5-OCF3, etc.; R2 = Me, Bn, allyl; R3 = Ph, 4-MeOC6H4, 1-naphthyl, etc.; Nuc = NHCH2C6H5, N-morpholinyl, N-pyrrolidinyl) in up to 92:8 dr and in >99:1 er.

Organic Letters published new progress about [2+2] Cycloaddition reaction catalysts (stereoselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lin, Zhiyang published the artcileSynthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C-F and C-O Bond Cleavage, Product Details of C11H12O3, the main research area is alkene trifluoromethyl acetal nickel allylic defluorinative coupling reaction catalyst; difluoroalkene preparation.

By merging C-O and C-F bond cleavage in cross-electrophile coupling, we developed a method for efficient synthesis of gem-difluoroalkenes with an alkoxy-substituent on the homoallylic position using easily accessible acetals as coupling partners with α-trifluoromethyl alkenes. Remarkably, this Ni-catalyzed allylic defluorinative cross-coupling reaction demonstrates high tolerance of a wide range of sensitive functional groups and proves to be applicable in late-stage functionalization of structurally complex compounds

ACS Catalysis published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Upadhyay, Rahul published the artcileV2O5@TiO2 Catalyzed Green and Selective Oxidation of Alcohols, Alkylbenzenes and Styrenes to Carbonyls, Synthetic Route of 86-51-1, the main research area is aldehyde ketone preparation green chem; alc alkylbenzene styrene selective oxidation vanadia titania catalyst.

The versatile application of different functional groups such as alcs. (1° and 2°), alkyl arenes, and (aryl)olefins to construct carbon-oxygen bond via oxidation is an area of intense research. Here, a reusable heterogeneous V2O5@TiO2 catalyzed selective oxidation of various functionalities utilizing different mild and eco-compatible oxidants under greener reaction conditions has been reported. The method was successfully applied for the alc. oxidation, oxidative scission of styrenes, and benzylic C-H oxidation to their corresponding aldehydes and ketones. The utilization of mild and eco-friendly oxidizing reagents such as K2S2O8, H2O2 (30% aqueous), TBHP (70% aqueous), broad substrate scope, gram-scale synthesis, and catalyst recyclability are notable features of the developed protocol.

ChemCatChem published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Synthetic Route of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Li, Peijun published the artcileA Platform for Decarboxylative Couplings via Photoredox Catalysis: Direct Access to Carbocations from Carboxylic Acids for Carbon-Oxygen Bond Formation, COA of Formula: C9H10O3, the main research area is ether chemoselective preparation; ruthenium photoredox catalyst oxidative decarboxylative etherification carboxylic acid alc.

Within the past decade, photoredox catalysis has enabled numerous decarboxylative transformations to couple carboxylic acids with a variety of partners primarily through carbon-centered radical intermediates. Herein, we describe a method for the construction of carbon-oxygen bonds using a dual photoredox/iodine(III) platform directly from simple carboxylic acids and alcs. This activation platform enables the direct utilization of readily available acids and alcs. without the need for prefunctionalization and works broadly across primary, secondary, and tertiary carboxylic acid substrates. We propose that this transformation proceeds via a radical-polar crossover event to generate a discrete carbocation intermediate which is intercepted by a nucleophilic coupling partner, thereby overcoming the electronically mismatched nature inherent in previous radical-based decarboxylative couplings. The application of this mechanistic approach toward addnl. nucleophiles is also demonstrated using water, enabling a direct decarboxylative-hydroxylation reaction. Finally, we demonstrated that the decarboxylative etherification can be applied to a peptide substrate, selectively functionalizing serine over other nucleophilic residues, providing support for future potential bioconjugation applications.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Xuewei published the artcileYnamide-Mediated Intermolecular Esterification, COA of Formula: C9H10O3, the main research area is ester preparation; carboxylic acid phenol alc intermol esterification ynamide.

An ynamide-mediated one-pot, two-step intermol. esterification via the condensation of carboxylic acids with nucleophilic hydroxyl species is reported. A broad substrate scope with respect to carboxylic acids, alcs., and phenols is observed The α-acyloxyenamide intermediates formed by the addition of carboxylic acids to ynamides proved to be effective acylating reagents for the esterification of alc. and phenol derivatives with the assistance of base catalysis. Notably, the racemization of the α-chiral center of carboxylic acids can be avoided.

Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ke, Lei published the artcileCatalytic Selective Oxidative Coupling of Secondary N-Alkylanilines: An Approach to Azoxyarene, Formula: C11H12O3, the main research area is azoxyarene preparation anticancer catalyst oxidative coupling secondary alkylaniline.

Azoxyarenes are among important scaffolds in organic mols. Direct oxidative coupling of primary anilines provides a concise fashion to construct them. However, whether these scaffolds can be prepared from secondary N-alkylanilines is not well explored. Here, the authors present a catalytic selective oxidative coupling of secondary N-alkylaniline to afford azoxyarene with tungsten catalyst under mild conditions. In addition, azoxy can be viewed as a bioisostere of alkene and amide. Several “”azoxyarene analogs”” of the corresponding bioactive alkenes and amides showed comparable promising anticancer activities.

Organic Letters published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Evdokimov, Nikolai M. published the artcileOne-Step, Three-Component Synthesis of Pyridines and 1,4-Dihydropyridines with Manifold Medicinal Utility, Formula: C11H12O3, the main research area is aldehyde thiol malononitrile cyclization pyridine enamino nitrile preparation.

Privileged medicinal scaffolds based on the structures of 2-amino-3,5-dicyano-6-sulfanylpyridines and the corresponding 1,4-dihydropyridines have been prepared via a single-step, three-component reaction of structurally diverse aldehydes with various thiols and malononitrile. Mechanistic studies revealed that 1,4-dihydropyridines undergo oxidation by the intermediate Knoevenagel adducts rather than by air oxygen. Although the latter process undermines the yields of pyridines, it results in the formation of substituted enamino nitriles, promising antiinflammatory agents.

Organic Letters published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Formula: C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Qinfang published the artcileConstruct indeno[1,2-b]oxepine or cis-cyclopropylacrylate by sulfur ylides, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is indenooxepine preparation; malononitrile aldehyde crotonate derived sulfur ylide annulation; cyclopropyl acrylate diastereoselective preparation; arylideneindenedione aldehyde crotonate derived sulfur ylide annulation.

For the first time, the [4 + 3] or [2 + 1] annulation of crotonate-derived sulfur ylides with arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione was reported using Na2CO3 as the base. This protocol was advantageous as it does not require prior preparation of arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione substrates, due to the independent participation of the base in the two reactions. This mild, operationally multicomponent process could be employed for the transformation of a wide variety of com. available aldehydes into the corresponding indeno[1,2-b]oxepines I [R = H, 4-CNC6H4, 2-OMeC6H4, etc.; R1 = Me, Et] or cyclopropyl acrylate core II in moderate to excellent yields under mild conditions.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem