Abdelhamid, Yusra published the artcileIsothiourea-Catalyzed [2+2] Cycloaddition of C(1)-Ammonium Enolates and N-Alkyl Isatins, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is beta hydroxyamide preparation diastereoselective enantioselective; alkyl isatin anhydride ammonium enolate cycloaddition ring opening isothiourea.
Enantioselective [2+2] cycloaddition of C(1)-ammonium enolates generated catalytically using the isothiourea HyperBTM with N-alkyl isatins gives spirocyclic β-lactones. In situ ring-opening with an amine nucleophile generates isolable highly enantioenriched products I (R1 = H, 6-Cl, 5-OCF3, etc.; R2 = Me, Bn, allyl; R3 = Ph, 4-MeOC6H4, 1-naphthyl, etc.; Nuc = NHCH2C6H5, N-morpholinyl, N-pyrrolidinyl) in up to 92:8 dr and in >99:1 er.
Organic Letters published new progress about [2+2] Cycloaddition reaction catalysts (stereoselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem