Li, Peijun published the artcileA Platform for Decarboxylative Couplings via Photoredox Catalysis: Direct Access to Carbocations from Carboxylic Acids for Carbon-Oxygen Bond Formation, COA of Formula: C9H10O3, the main research area is ether chemoselective preparation; ruthenium photoredox catalyst oxidative decarboxylative etherification carboxylic acid alc.
Within the past decade, photoredox catalysis has enabled numerous decarboxylative transformations to couple carboxylic acids with a variety of partners primarily through carbon-centered radical intermediates. Herein, we describe a method for the construction of carbon-oxygen bonds using a dual photoredox/iodine(III) platform directly from simple carboxylic acids and alcs. This activation platform enables the direct utilization of readily available acids and alcs. without the need for prefunctionalization and works broadly across primary, secondary, and tertiary carboxylic acid substrates. We propose that this transformation proceeds via a radical-polar crossover event to generate a discrete carbocation intermediate which is intercepted by a nucleophilic coupling partner, thereby overcoming the electronically mismatched nature inherent in previous radical-based decarboxylative couplings. The application of this mechanistic approach toward addnl. nucleophiles is also demonstrated using water, enabling a direct decarboxylative-hydroxylation reaction. Finally, we demonstrated that the decarboxylative etherification can be applied to a peptide substrate, selectively functionalizing serine over other nucleophilic residues, providing support for future potential bioconjugation applications.
ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, COA of Formula: C9H10O3.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem