Tag: M.W:200-300

Praveen, Chandrasekaran; Ayyanar, Asairajan; Perumal, Paramasivan Thirumalai published the article 《Gold(III) chloride catalyzed regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones and evaluation of anticancer potential towards human cervix adenocarcinoma》. Keywords: pyranoindolone preparation anticancer; iodoindolecarboxylate preparation alkyne cross coupling hydrolysis cycloisomerization gold catalyst.They researched the compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6 ).Category: isoquinoline. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:67929-86-6) here.

A highly regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones via gold(III) chloride catalyzed cycloisomerization of 3-ethynyl-indole-2-carboxylic acid was achieved in good to excellent yields. These compounds were screened for their in vitro cytotoxicity against human cervical (HeLa) cell lines. Out of ten compounds, three compounds I (R = Me, Et, H) showed comparable proliferation inhibitory activity against the standard drug cisplatin. Compound I (r = Me) was found to be the most efficacious with IC50 value of 0.22 μM.

After consulting a lot of data, we found that this compound(67929-86-6)Category: isoquinoline can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 67929-86-6, is researched, Molecular C11H11NO3, about Arylthioindoles, Potent Inhibitors of Tubulin Polymerization, the main research direction is arylthioindole preparation tubulin polymerization inhibitor.Related Products of 67929-86-6.

Several arylthioindoles had excellent activity as inhibitors both of tubulin polymerization and of the growth of MCF-7 human breast carcinoma cells. Me 3-[(3,4,5-trimethoxyphenyl)thio]-5-methoxy-1H-indole-2-carboxylate (I), the most potent derivative, showed IC50 = 2.0 μM, 1.6 times more active than colchicine and about as active as combretastatin A-4 (CSA4). Compound I inhibited the growth of the MCF-7 cells at IC50 = 13 nM. Colchicine and CSA4 had 13 nM and 17 nM IC50 values, resp., with these cells.

After consulting a lot of data, we found that this compound(67929-86-6)Related Products of 67929-86-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1671-88-1, is researched, SMILESS is NN1C(C2=NC=CC=C2)=NN=C1C3=NC=CC=C3, Molecular C12H10N6Journal, Inorganica Chimica Acta called Synthesis, x-ray structure, spectroscopic and magnetic properties of [bis(4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole-N’,N1)(aqua)copper(II)] bis(hydrogensulfate), Author is van Koningsbruggen, Petra J.; Goubitz, Kees; Haasnoot, Jaap G.; Reedijk, Jan, the main research direction is copper aminobispyridyltriazole complex preparation structure; crystal structure copper aminobispyridyltriazole complex; hydrogen bond copper aminobispyridyltriazole complex.Name: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine.

The synthesis, crystal structure, spectroscopic and magnetic properties of a five-coordinated mononuclear Cu(II) compound with the ligand 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole (abpt) (abbreviated as abpt) is reported. [Cu(abpt)2(H2O)](HSO4)2 crystallizes in the triclinic space group C2/c, with a 15.0685(9), b 9.6108(5), c 19.691(1) Å, β 93.611(5)°, V = 2846.0(3) Å3 and Z = 4. The least-squares refinement based on 2028 significant reflections, with I > 2.5σI, converged to R = 0.037 and Rw = 0.043. The mol. structure consists of a mononuclear five-coordinated Cu(II) cation. Two abpt ligands act as bidentate chelating ligands with Cu-N(1) = 1.958(3), Cu-N(51) = 2.066(3) Å and an N(1)-Cu-N(51) angle of 80.1(1)°. A H2O mol. is coordinated (Cu-O(1) = 2.124(4) Å). The Cu and O(1) are in special positions. The anions are the unusual hydrogensulfate (HSO4-) which have remarkably short acceptor H bonds to the same coordinating H2O mol. (O(1)-O(13) (1-x, y, 0.50-z) = 2.701(4), H(1)-O(13) (1-x, y, 0.50-z) = 1.74(4) Å, O(1)-H(1)···O(13) (1-x, y, 0.50-z) = 167(4)°). Absorptions of the (low symmetry) H bonded hydrogensulfate anion can easily be found in the IR spectrum. The X-band powder ESR spectra show the usual rhombic spectrum for a Cu(II) ion in a five-coordination. Despite the strong H-bonding network no evidence for Cu···Cu exchange splittings are observed, in agreement with the magnetic susceptibility measurements over the temperature range 4.2-290 K, where the product of the magnetic susceptibility and the temperature remains constant at 0.325 cm3 mol-1 K.

The article 《Synthesis, x-ray structure, spectroscopic and magnetic properties of [bis(4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole-N’,N1)(aqua)copper(II)] bis(hydrogensulfate)》 also mentions many details about this compound(1671-88-1)Name: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine, you can pay attention to it, because details determine success or failure

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wood, Jill; Bagi, Cedo M.; Akuche, Christiana; Bacchiocchi, Antonietta; Baryza, Jeremy; Blue, Marie-Luise; Brennan, Catherine; Campbell, Ann-Marie; Choi, Soongyu; Cook, James H.; Conrad, Patricia; Dixon, Brian R.; Ehrlich, Paul P.; Gane, Todd; Gunn, David; Joe, Ted; Johnson, Jeffrey S.; Jordan, Jerold; Kramss, Richard; Liu, Peiying; Levy, Joan; Lowe, Derek B.; McAlexander, Ian; Natero, Reina; Redman, Aniko M.; Scott, William J.; Town, Christopher; Wang, Ming; Wang, Yamin; Zhang, Zhonghua published the article 《4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate》. Keywords: pyrrolidinone preparation hydroxysteroid dehydrogenase inhibitor SAR.They researched the compound: 2-(5-Bromothiophen-2-yl)pyridine( cas:123784-07-6 ).Formula: C9H6BrNS. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:123784-07-6) here.

A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17β-HSD II for the treatment of osteoporosis. Biochem. data for several compounds are given. Compound I was selected as the lead candidate.

The article 《4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate》 also mentions many details about this compound(123784-07-6)Formula: C9H6BrNS, you can pay attention to it, because details determine success or failure

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Diphenyl-2-pyridylphosphine(SMILESS: P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=NC=CC=C3,cas:37943-90-1) is researched.Formula: C9H6BrNS. The article 《Two new micro-isostructural metal-organic polymers based on mixed-ligand copper(I): Structures and selective sensing of nitro explosives in water》 in relation to this compound, is published in Applied Organometallic Chemistry. Let’s take a look at the latest research on this compound (cas:37943-90-1).

Two new one-dimensional metal-organic polymers (MOPs) {[Cu2(L)(PPh2Py)2·I2]·CH3Cl}n (1) and {[Cu2(L)(PPh2Py)2·Br2]·CH3Cl}n (2) (L = (1E,2E)-1,2-bis(pyridine-4-ylmethylene)hydrazine) (4-bpmh) have been synthesized and elucidated by single crystal x-ray diffraction. The results of x-ray diffraction anal. unambiguously revealed that the two polymers are isostructural with the major intermol. CH···π and π···π interactions. Microstructures of these polymers were also synthesized using a sonochem. method in different concentrations and reaction times. Field emission SEM, powder x-ray diffraction, thermogravimetric anal. and IR spectroscopy were applied to fully characterize these compounds The photoluminescent properties of microrod MOPs were also evaluated to add to authors understanding of their potential ability for nitro compound sensing. These experiments showed that MOPs 1 and 2 are good luminescence sensors for detection of nitro explosives in aqueous media. The probes maintained their high sensitivity and selectivity for 4-nitrophenol (4-NP). The energy transfer process accompanied by electrostatic interactions of 4-NP with these MOPs can be considered as an influential reason for the selectivity of 4-NP. The competitive study of the quenching process has also shown superior operation with microparticles compared with bulky polymers. These results indicate that this method may be useful to synthesize luminescent materials possessing good sensing properties.

The article 《Two new micro-isostructural metal-organic polymers based on mixed-ligand copper(I): Structures and selective sensing of nitro explosives in water》 also mentions many details about this compound(37943-90-1)Recommanded Product: 37943-90-1, you can pay attention to it, because details determine success or failure

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Setifi, Zouaoui; Setifi, Fatima; Glidewell, Christopher; Gil, Diego M.; Kletskov, Alexey V.; Echeverria, Jorge; Mirzaei, Masoud published an article about the compound: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine( cas:1671-88-1,SMILESS:NN1C(C2=NC=CC=C2)=NN=C1C3=NC=CC=C3 ).Safety of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1671-88-1) through the article.

The solvothermal synthesis and structural characterization of the new high-spin iron(II) complex trans,trans,trans-[bis(azido)bis(4-amino-3,5-bis(2-pyridyl)-1,2,4-triazole)iron(II)] is reported. The complex crystallizes in the triclinic space group Pi with Z = 1, a 6.6648(3), b 8.4012(3), c 11.7970(5) Å, α 85.063(2), β 95.063(2), γ 98.5080(10)°. It is centrosym. with mutually trans pairs of azido, pyridyl and triazole N atoms, the Fe-N distances indicate a high-spin configuration. A combination of N-H···N hydrogen bonds and π···π stacking interactions generates a sheet structure in which the shortest Fe···Fe distance is 6.6648(3) Å. Hirshfeld surface anal. was performed for visualizing, exploring and quantifying intermol. interactions that stabilize the crystal packing of the complex. Noncovalent interactions present in the crystal structure also were analyzed by computational tools. The interaction energies associated with the different interaction topologies were calculated and QTAIM and NBO analyses were applied to study the origin and nature of the attractive forces.

The article 《An iron(II) complex of trans, trans, trans-bis(azido)bis(4-amino-3,5-bis(2-pyridyl)-1,2,4-triazole): Insight into molecular and supramolecular structures using Hirshfeld surface analysis and DFT studies》 also mentions many details about this compound(1671-88-1)Safety of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine, you can pay attention to it, because details determine success or failure

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine( cas:1671-88-1 ) is researched.Formula: C12H10N6.Guo, Jian; Tang, Min; Chen, Jing; Li, Cheng-Peng published the article 《Di-μ-chlorido-bis{[4-amino-3,5-bis(2-pyridyl)-4H-1,2,4-triazole-κN1]chloridomercury(II)}》 about this compound( cas:1671-88-1 ) in Acta Crystallographica, Section E: Structure Reports Online. Keywords: aminopyridyltriazole chlorido mercury crystal mol structure. Let’s learn more about this compound (cas:1671-88-1).

In the centrosym. binuclear title complex, [Hg2Cl4(C12H10N6)2], the Hg(II) ion is 5-coordinated by 2 N atoms and three chloride ions with a distorted square-pyramidal geometry. In the complex, there is an intramol. N-H···N H-bond. In the crystal, the binuclear units are connected by intermol. N-H···Cl H-bonds, as well as π-π stacking interactions [centroid-centroid distances = 3.526(2) and 3.696(2) Å], forming a 2D layered structure parallel to (010). Crystal data: orthorhombic, Pbca, a = 11.3634(4), b = 14.9962(6), c = 17.2328(7) Å, Z = 4, 2071 observed reflections with I > 2σ(I), 190 refined parameters, R[F2 > 2σ(F2)] = 0.022, wR(F2) = 0.058.

The article 《Di-μ-chlorido-bis{[4-amino-3,5-bis(2-pyridyl)-4H-1,2,4-triazole-κN1]chloridomercury(II)}》 also mentions many details about this compound(1671-88-1)Formula: C12H10N6, you can pay attention to it, because details determine success or failure

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Preti, Delia; Romagnoli, Romeo; Rondanin, Riccardo; Cacciari, Barbara; Hamel, Ernest; Balzarini, Jan; Liekens, Sandra; Schols, Dominique; Estevez-Sarmiento, Francisco; Quintana, Jose; Estevez, Francisco published an article about the compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6,SMILESS:O=C(C(N1)=CC2=C1C=CC(OC)=C2)OC ).Reference of Methyl 5-methoxyindole-2-carboxylate. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:67929-86-6) through the article.

Inhibition of microtubule function using tubulin targeting agents has received growing attention in the last several decades. The indole scaffold has been recognized as an important scaffold in the design of novel compounds acting as antimitotic agents. Indole-based chalcones, in which one of the aryl rings was replaced by an indole, have been explored in the last few years for their anticancer potential in different cancer cell lines. Eighteen novel (3′,4′,5′-trimethoxyphenyl)-indolyl-propenone derivatives with general structure were synthesized and evaluated for their antiproliferative activity against a panel of four different human cancer cell lines. The highest IC50 values were obtained against the human promyelocytic leukemia HL-60 cell line. This series of chalcone derivatives was characterized by the presence of a 2-alkoxycarbonyl indole ring as the second aryl system attached at the carbonyl of the 3-position of the 1-(3′,4′,5′-trimethoxyphenyl)-2-propen-1-one framework. The structure-activity relationship (SAR) of the indole-based chalcone derivatives was investigated by varying the position of the methoxy group, by the introduction of different substituents (hydrogen, Me, Et or benzyl) at the N-1 position and by the activity differences between methoxycarbonyl and ethoxycarbonyl moieties at the 2-position of the indole nucleus. The antiproliferative activity data of the novel synthesized compounds revealed that generally N-substituted indole analogs exhibited considerably reduced potency as compared with their parent N-unsubstituted counterparts, demonstrating that the presence of a hydrogen on the indole nitrogen plays a decisive role in increasing antiproliferative activity. The results also revealed that the position of the methoxy group on the indole ring is a critical determinant of biol. activity. Among the synthesized derivatives, compound , containing the 2-methoxycarbonyl-6-methoxy-N-1H-indole moiety exhibited the highest antiproliferative activity, with IC50 values of 0.37, 0.16 and 0.17 μM against HeLa, HT29 and MCF-7 cancer cell lines, resp., and with considerably lower activity against HL-60 cells (IC50: 18 μM). This derivative also displayed cytotoxic properties (IC50 values ∼1 μM) in the human myeloid leukemia U-937 cell line overexpressing human Bcl-2 (U-937/Bcl-2) via cell cycle progression arrest at the G2-M phase and induction of apoptosis. The results obtained also demonstrated that the antiproliferative activity of this mol. is related to inhibition of tubulin polymerization The presence of a methoxy group at the C5- or C6-position of the indole nucleus, as well as the absence of substituents at the N-1-indole position, contributed to the optimal activity of the indole-propenone-3′,4′,5′-trimethoxyphenyl scaffold.

The article 《Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3′,4′,5′-trimethoxyphenyl)-3-(2′-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach》 also mentions many details about this compound(67929-86-6)Reference of Methyl 5-methoxyindole-2-carboxylate, you can pay attention to it, because details determine success or failure

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Methyl 5-methoxyindole-2-carboxylate, is researched, Molecular C11H11NO3, CAS is 67929-86-6, about [Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source, the main research direction is indole alkaloid synthesis intramol cyclization porphyrin iron catalyst; tetrahydroquinoline alkaloid synthesis intramol cyclization porphyrin iron catalyst; dihydroquinazolinone alkaloid synthesis intramol cyclization porphyrin iron catalyst; quinazolinone alkaloid synthesis intramol cyclization porphyrin iron catalyst.Electric Literature of C11H11NO3.

The syntheses of alkaloids including indoles, indolines, tetrahydroquinolines, dihydroquinazolinones and quinazolinones were accomplished in moderate to excellent yields via [Fe(F20TPP)Cl] (I) catalyzed intramol. C-N bond formation using aryl azides as nitrogen source. E.g., dihydroquinazolinone derivative II was prepared with 83% yield by refluxing N3-2-C6H4CON(CH2Ph)2 with I in (ClCH2)2.

The article 《[Fe(F20TPP)Cl] catalyzed intramolecular C-N bond formation for alkaloid synthesis using aryl azides as nitrogen source》 also mentions many details about this compound(67929-86-6)Electric Literature of C11H11NO3, you can pay attention to it, because details determine success or failure

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Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine( cas:1671-88-1 ) is researched.Application In Synthesis of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine.Vahovska, Lucia; Bukrynov, Oleksandr; Potocnak, Ivan; Cizmar, Erik; Kliuikov, Andrii; Vitushkina, Svitlana; Dusek, Michal; Herchel, Radovan published the article 《New Cobalt(II) Field-Induced Single-Molecule Magnet and the First Example of a Cobalt(III) Complex with Tridentate Binding of a Deprotonated 4-Amino-3,5-bis(pyridin-2-yl)-1,2,4-Triazole Ligand》 about this compound( cas:1671-88-1 ) in European Journal of Inorganic Chemistry. Keywords: crystal structure cobalt pyridinyltriazole azido mononuclear dinuclear; cobalt pyridinyltriazole azido mononuclear preparation magnetic relaxation SMM. Let’s learn more about this compound (cas:1671-88-1).

From Co(NO3)2·6H2O – NaN3 – abpt reaction system, mononuclear [Co(abpt)2(N3)2] (abpt = 4-amino-3,5-bis(pyridin-2-yl)-1,2,4-triazole) (1) and dinuclear [Co2(abpt)(μ-abpt-H)2(N3)4]·1.12H2O (2) were obtained. The presence of neutral abpt, as well as azido ligands was proved by IR spectroscopy. X-ray crystallog. shows that 1 is a mol. CoII complex with two azido ligands coordinated in trans-positions, while 2 is a dinuclear CoIII complex bridged by two abpt-H ligands. π-π Stacking interactions between pyridyl rings of abpt and N-H···N and C-H···N H bonds in 1 and 2 stabilize their structures by creating a 3-dimensional supramol. network. The anal. of the magnetic properties of 1 revealed neg. zero-field splitting parameter D = -24.1 cm-1 supported also by CASSCF/NEVPT2 and CASSCF/CASPT2 theor. calculations The X-band ESR also gives an evidence for a strong rhombic character of the anisotropy. The study of the a.c. susceptibility measurements identified 1 as a field-induced single-mol. magnet, in which direct, Raman and Orbach relaxation processes are present.

The article 《New Cobalt(II) Field-Induced Single-Molecule Magnet and the First Example of a Cobalt(III) Complex with Tridentate Binding of a Deprotonated 4-Amino-3,5-bis(pyridin-2-yl)-1,2,4-Triazole Ligand》 also mentions many details about this compound(1671-88-1)Application In Synthesis of 3,5-Di(pyridin-2-yl)-4H-1,2,4-triazol-4-amine, you can pay attention to it, because details determine success or failure

Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem