Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 67929-86-6, is researched, Molecular C11H11NO3, about Arylthioindoles, Potent Inhibitors of Tubulin Polymerization, the main research direction is arylthioindole preparation tubulin polymerization inhibitor.Related Products of 67929-86-6.
Several arylthioindoles had excellent activity as inhibitors both of tubulin polymerization and of the growth of MCF-7 human breast carcinoma cells. Me 3-[(3,4,5-trimethoxyphenyl)thio]-5-methoxy-1H-indole-2-carboxylate (I), the most potent derivative, showed IC50 = 2.0 μM, 1.6 times more active than colchicine and about as active as combretastatin A-4 (CSA4). Compound I inhibited the growth of the MCF-7 cells at IC50 = 13 nM. Colchicine and CSA4 had 13 nM and 17 nM IC50 values, resp., with these cells.
After consulting a lot of data, we found that this compound(67929-86-6)Related Products of 67929-86-6 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem