Praveen, Chandrasekaran; Ayyanar, Asairajan; Perumal, Paramasivan Thirumalai published the article 《Gold(III) chloride catalyzed regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones and evaluation of anticancer potential towards human cervix adenocarcinoma》. Keywords: pyranoindolone preparation anticancer; iodoindolecarboxylate preparation alkyne cross coupling hydrolysis cycloisomerization gold catalyst.They researched the compound: Methyl 5-methoxyindole-2-carboxylate( cas:67929-86-6 ).Category: isoquinoline. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:67929-86-6) here.
A highly regioselective synthesis of pyrano[3,4-b]indol-1(9H)-ones via gold(III) chloride catalyzed cycloisomerization of 3-ethynyl-indole-2-carboxylic acid was achieved in good to excellent yields. These compounds were screened for their in vitro cytotoxicity against human cervical (HeLa) cell lines. Out of ten compounds, three compounds I (R = Me, Et, H) showed comparable proliferation inhibitory activity against the standard drug cisplatin. Compound I (r = Me) was found to be the most efficacious with IC50 value of 0.22 μM.
After consulting a lot of data, we found that this compound(67929-86-6)Category: isoquinoline can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem