Wood, Jill; Bagi, Cedo M.; Akuche, Christiana; Bacchiocchi, Antonietta; Baryza, Jeremy; Blue, Marie-Luise; Brennan, Catherine; Campbell, Ann-Marie; Choi, Soongyu; Cook, James H.; Conrad, Patricia; Dixon, Brian R.; Ehrlich, Paul P.; Gane, Todd; Gunn, David; Joe, Ted; Johnson, Jeffrey S.; Jordan, Jerold; Kramss, Richard; Liu, Peiying; Levy, Joan; Lowe, Derek B.; McAlexander, Ian; Natero, Reina; Redman, Aniko M.; Scott, William J.; Town, Christopher; Wang, Ming; Wang, Yamin; Zhang, Zhonghua published the article 《4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate》. Keywords: pyrrolidinone preparation hydroxysteroid dehydrogenase inhibitor SAR.They researched the compound: 2-(5-Bromothiophen-2-yl)pyridine( cas:123784-07-6 ).Formula: C9H6BrNS. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:123784-07-6) here.
A series of 4,5-disubstituted cis-pyrrolidinones was investigated as inhibitors of 17β-HSD II for the treatment of osteoporosis. Biochem. data for several compounds are given. Compound I was selected as the lead candidate.
The article 《4,5-Disubstituted cis-pyrrolidinones as inhibitors of type II 17β-hydroxysteroid dehydrogenase. Part 3. Identification of lead candidate》 also mentions many details about this compound(123784-07-6)Formula: C9H6BrNS, you can pay attention to it, because details determine success or failure
Reference:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem