Day: November 10, 2022

Gao, Hui published the artcileElectrochemical benzylic C-H arylation of xanthenes and thioxanthenes without a catalyst and oxidant, Safety of 1,3-Dimethoxybenzene, the main research area is aryl xanthene preparation; xanthene arene electrochem arylation reaction; arylthioxanthene preparation; arene thioxanthene electrochem arylation reaction.

A catalyst-free and oxidant-free C-H arylation of xanthenes and thioxanthenes I (R1 = H, Me, OH, Cl, etc.; R2 = H, OMe; R3R4 = -CH=CH-CH=CH-; X = O, S) using electrochem. has been developed, which affords a number of cross-coupling products II (R5 = 4-methoxyphenyl, 4-methoxy-3-methylphenyl, 4-methoxy-3,5-dimethylphenyl, 2H-1,3-benzodioxol-5-yl, etc.) in moderate to good yields. This method is atom- and step-economical as it uses cheap and easily available arenes and heteroarenes as partners directly and the C(sp2)-H/C(sp3)-H type cross-coupling reaction.

Organic Chemistry Frontiers published new progress about Arylation. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tran, Phuong Hoang published the artcileMagnetically recoverable γ-Fe2O3 nanoparticles as a highly active catalyst for Friedel-Crafts benzoylation reaction under ultrasound irradiation, Category: isoquinoline, the main research area is recoverable magnetic iron oxide nanocatalyst preparation surface structure; arene benzoyl chloride iron oxide nanocatalyst Friedel Crafts benzoylation; diaryl ketone regioselective preparation ultrasonication irradiation green chem.

A simple, facile and efficient method was developed for the Friedel-Crafts benzoylation of arenes using magnetic γ-Fe2O3 nanoparticles under solvent-free sonication. The γ-Fe2O3 nanoparticles were used as an efficient and magnetically recoverable catalyst for the synthesis of aromatic ketones in good to excellent yields at room temperature under solvent-free conditions. The reaction occurred with high regioselectivity under mild condition. The magnetic γ-Fe2O3 nanoparticles were economically synthesized in large-scale, easily separated from the reaction mixture by an external magnet and able to be reused several times without significant loss of the catalytic performance, which made them easy application to industrial processes.

Arabian Journal of Chemistry published new progress about Aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Narobe, Rok published the artcilePhotocatalytic Oxidative Iodination of Electron-Rich Arenes, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is arene anthraquinone photocatalyst regioselective oxidative iodination green chem; iodoarene preparation.

A visible-light-mediated oxidative iodination of electron-rich arenes was developed. 2.5 mol% of unsubstituted anthraquinone as photocatalyst were used in combination with elementary iodine, trifluoroacetic acid and oxygen as the terminal oxidant. The iodination proceeded upon irradiation in non- or weakly-electron donating solvents (DCM, DCE and benzene) wherein a spectral window in strongly colored iodine solutions was observed at around 400 nm. The method provided good to excellent yields (up to 98%) and showed excellent regioselectivity and good functional group tolerance (triple bonds, ketone, ester, amide). Moreover, the photo-iodination was also upscaled to a 5 mmol scale (1.1 g). Mechanistic investigations by intermediate trapping and competition experiments indicate a photocatalytic arene oxidation and the subsequent reaction with iodine as a likely mechanistic pathway.

Advanced Synthesis & Catalysis published new progress about Aryl iodides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Abudken, Ahmed M. H. published the artcileFluorinations of unsymmetrical diaryliodonium salts containing ortho-sidearms; influence of sidearm on selectivity, Synthetic Route of 151-10-0, the main research area is arene fluoroiodane fluorination; fluoroarene preparation.

Activated aromatics were reacted with two different fluoroidoane reagents in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane the unsym. diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alc. sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Organic & Biomolecular Chemistry published new progress about Aryl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Deng, Jing published the artcileQuality comparison of sweet flour pastes produced via natural and temperature-controlled fermentation, Name: 5-Methyl-2-phenylhex-2-enal, the main research area is sweet flour paste quality natural temperature controlled fermentation.

The quality of sweet flour pastes (SFP) produced via natural and temperature-controlled fermentation was investigated. Temperature-controlled fermentation shortened the production time with no significant (p<0.05) differences between sample types in amino nitrogen, total acid, reducing sugar, and organic acid concentrations observed at the end of fermentation Naturally fermented SFP exhibited higher concentrations of free amino acids than temperature-controlled fermented SFP. Anal. of SFP volatile compounds showed that naturally fermented SFP samples had higher concentrations of aroma constituents. Et palmitate was the dominant ester in SFP with a 5.2× higher content of Et palmitate than for naturally fermented SFP. In addition, 4-Et guaiacol and 4-vinyl guaiacol were only identified in naturally fermented SFP samples. Temperature-controlled fermentation accelerates the production process, and naturally fermented SFP exhibited a higher quality. Food Science and Biotechnology published new progress about Fermentation. 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Name: 5-Methyl-2-phenylhex-2-enal.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tian, Li published the artcileCopper-catalyzed ring-opening C(sp3)-N coupling of cycloketone oxime esters: access to 1°, 2° and 3° alkyl amines, HPLC of Formula: 5961-59-1, the main research area is cycloalkanone oxime ester secondary amine copper ring opening coupling; cyanoalkyl arylamine preparation.

A novel copper-catalyzed C(sp3)-N coupling of cycloketone oxime esters with nitrogen nucleophiles were realized. All of the N-aryl/alkylanilines, anilines and benzophenone imine were employed in this protocol to produce a variety of 1°, 2° and 3° alkyl amines in one or two steps. These resultant cyano-containing alkyl amines were proved to be versatile synthetic building blocks in a variety of chem. transformations.

Chemical Communications (Cambridge, United Kingdom) published new progress about Coupling reaction. 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Habert, Loic published the artcilePhotoinduced Aerobic Iodoarene-Catalyzed Spirocyclization of N-Oxy-amides to N-Fused Spirolactams, Computed Properties of 104-01-8, the main research area is oxyamide fused spirolactam preparation photoinduced aerobic iodoarene catalyst spirocyclization; aerobic photoredox reaction; dual organocatalysis; hypervalent iodine; pyrylium.

Iodoarene catalysis is a powerful methodol. that usually requires an excess of oxidant, or of redox mediator if the terminal oxidant is dioxygen, to generate the key hypervalent iodine intermediate to proceed efficiently. The authors report that, using the spiro-cyclization of amides as a benchmark reaction, aerobic iodoarene catalysis can be enabled by relying on a pyrylium photocatalyst under blue light irradiation This unprecedented dual organocatalytic system allows the use of low catalytic loading of both catalysts under very mild operating conditions.

Angewandte Chemie, International Edition published new progress about Spiro lactams Role: SPN (Synthetic Preparation), PREP (Preparation) (N-Fused). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bonderoff, Sara A. published the artcileSuperacid-catalyzed Friedel-Crafts cyclization of unactivated alkenes, Computed Properties of 1205-17-0, the main research area is unactivated alkene preparation intramol Friedel Crafts cyclization trifluoromethanesulfonimide; spiro benzoxocine cyclopropane preparation mol crystal structure; tetralin preparation; trifluoromethanesulfonimide intramol Friedel Crafts cyclization superacid catalyst.

Trifluoromethanesulfonimide is an effective catalyst for Friedel-Crafts cyclizations of simple, nonpolarized alkenes with a variety of pendant arenes. A catalyst loading of 0.5 – 1.0 mol % effects clean cyclization to form 5- to 7-membered carbocycles with generally short reaction times and good to excellent yields under reflux or microwave heating. X-rays single crystal structure of compound I is shown.

Tetrahedron Letters published new progress about Crystal structure. 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Computed Properties of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Guang-Li published the artcilePalladium-Catalyzed Reaction of 2,3-Allenols with Amines: Synthesis of [3]Dendralenes and 1,3-Dienes Containing Allylic Amino and Hydroxy Groups, HPLC of Formula: 5961-59-1, the main research area is allenol amine palladium catalyst chemoselective diastereoselective nucleophilic addition; dendralene preparation; amine allenol palladium catalyst chemoselective diastereoselective nucleophilic addition; alkadienol preparation.

Palladium-catalyzed reaction of 2,3-allenols with amines was carried out to construct conjugated polyenes with allylic amino and hydroxy groups. [Pd(π-allyl)Cl]2/P(2-furyl)3-catalyzed reaction in MeOH led to (Z)-configurated [3]dendralene derivatives and Pd(OAc)2/P(2-furyl)3-catalyzed reaction in iPrOH resulted in (1Z,3E)-1,3-diene derivatives

Advanced Synthesis & Catalysis published new progress about Alkadienes Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Schwarz, J. Luca published the artcileDialkylation of 1,3-Dienes by Dual Photoredox and Chromium Catalysis, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is homoallylic alc diastereoselective enantioselective preparation; aldehyde Hatzsch ester diene multicomponent photoredox dialkylation chromium catalyst.

The direct conversion of feedstock chems. into value-added products is of broad interest in chem. research. Herein, we present a regioselective and diastereoselective three-component dialkylation of feedstock 1,3-dienes with Hantzsch esters and aldehydes for the synthesis of homoallylic alcs. The reaction is enabled by dual photoredox and chromium catalysis and can also be performed enantioselectively by employing chromium-bisoxazoline complexes.

ACS Catalysis published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Recommanded Product: 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem