Day: November 17, 2022

Zhang, Yuanyuan published the artcileChiral Selenide-Catalyzed, Highly Regio- and Enantioselective Intermolecular Thioarylation of Alkenes with Phenols, Application of 1,3-Dimethoxybenzene, the main research area is chiral phenol preparation regioselective enantioselective diastereoselective; alkene phenol thiosuccinimide three component thioarylation chiral selenide catalyst.

Enantioselective electrophilic three-component thioarylation of alkenes by chiral selenide catalysis with free phenols as arylating sources is disclosed. A variety of chiral phenols, e.g., I, were prepared in high regio-, enantio-, and diastereoselectivities. Mechanistic studies revealed that this transformation went through carbon nucleophilic attack to give the products rather than the process of intramol. rearrangement of phenolic ether intermediates. The application of this organocatalytic method in the alkylation of methoxy-substituted benzenes elucidated its generality.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Lei published the artcileRhenium-catalyzed alkylarylation of alkenes with PhI(O2CR)2via decarboxylation to access indolinones and dihydroquinolinones, Product Details of C8H11NO, the main research area is indolinone preparation regioselective; alkene hypervalent iodine compound cyclization rhenium catalyst; dihydroquinolinone preparation regioselective diastereoselective; cinnamamide hypervalent iodine compound cyclization rhenium catalyst.

Rhenium-catalyzed alkylarylation of alkenes RN(R1)C(O)C(=CH2)R2 (R = C6H5, 4-FC6H4, 2-CH3C6H4, etc.; R1 = CH3, CH2CH3, CH(CH3)2, C(O)CH3; R2 = Me, Ph) and 4-R3C6H4N(Me)C(O)CH=CHAr (R3 = Me, F, OMe, etc.; Ar = C6H5, 4-ClC6H4) with hypervalent iodine(III) reagents (HIRs) PhI(O2CR4)2 (R4 = Me, i-Pr, cyclopropyl, etc.) via decarboxylation to access various 3,3-disubstituted indolinones I (R5 = 5-F, 7-Me, 5-CN, etc.) and trans-3,4-dihydroquinolinones trans-II (R6 = Me, F, CF3, etc.) is described. These transformations feature wide substrate scopes, good functional-group tolerance, and divergent regioselectivity. Mechanistic studies revealed a cascade sequence of decarboxylation/intermol. radical alkylation/intramol. radical arylation/oxidative re-aromatization.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Product Details of C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Shambhavi, Chikkabagilu Nagaraju published the artcileRh(III)-Catalyzed Enone Carbonyl/Ketone-Directed Aerobic C-H Olefination of Aromatics with Unactivated Olefins, Product Details of C9H10O3, the main research area is chalcone alkene rhodium catalyst regioselective diastereoselective olefination; alkenyl chalcone preparation.

A Rh(III)-catalyzed weak enone carbonyl/ketone-assisted aerobic oxidative C-H olefination of aromatics with unactivated alkenes was developed. This protocol involves cross-dehydrogenative Heck-type olefination reaction of various substituted biol. relevant chalcones and aromatic ketones such as acetophenones and chromones with various functionalized unactivated olefins in moderate to good yields. Further, ortho-alkylation of chalcones with norbornene was also demonstrated. A possible reaction mechanism involving weak chelation-assisted C-H activation/insertion/β-hydride elimination was proposed and supported by the deuterium labeling studies.

Journal of Organic Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Product Details of C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Mondal, Haripriyo published the artcileCooperativity within the catalyst: alkoxyamide as a catalyst for bromocyclization and bromination of (hetero)aromatics, SDS of cas: 151-10-0, the main research area is bromolactone aryl bromide chemoselective preparation; methoxybutanesulfonamide catalyst bromosuccinimide mediated bromocyclization bromination; chemoselective bromination bromocyclization methoxysulfonamide catalyst bromosuccinimide.

N-Methoxy-1-butanesulfonamide was a recyclable catalyst for the activation of N-bromosuccinimide to perform bromocyclization and bromination reactions of unsaturated carboxylic acids, alkenes and indoles with pendant nucleophiles, and arenes in heptane, where adequate suppression of the background reactions was observed, to yield bromolactones, bromomethyl-substituted heterocycles, fused indolines such as pyrroloindolines, and aryl bromides. The key feature of the active site is the alkoxy group attached to the sulfonamide moiety, which facilitates the acceptance as well as the delivery of bromonium species from the bromine source to the substrates.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Dalai, Pallaba Ganjan published the artcileGeneration of Dimethyl Sulfoxide Coordinated Thermally Stable Halogen Cation Pools for C-H Halogenation, Name: 1,3-Dimethoxybenzene, the main research area is arene DMSO coordinated halogen halogenation; haloarene preparation; alkene DMSO coordinated bromide halogenation; dibromoalkane preparation; diketone preparation; enamide DMSO coordinated bromide intramol cyclization; oxazole preparation.

A method to generate halogen cation pools from the reaction of 1,2-dihaloethanes (hal=Br, I) and DMSO (DMSO) for C-H halogenation of arenes and heteroarenes was reported. The initial reaction of DMSO and 1,2-dihaloethane generates the sulfur ylide, which undergoes pyrolytic elimination of ethylene by affording halonium ions. These ions were accumulated and stabilized by DMSO through coordination by forming halogen cation pools for the halogenation reaction. This protocol was selective for electrophilic monohalogenation of arenes at room temperature; however, polyhalogenated products were formed by raising the reaction temperature Late-stage halogenation of heteroarenes and some commonly marketed drugs signifies the synthetic utility of this protocol in pharmaceutical chem. Unlike the classical methods, the in-situ generated electrophilic bromonium ion was further exploited for the direct synthesis of α-diketones from the alkenes under base-free conditions.

Advanced Synthesis & Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Chen, Bi-Hong published the artcileOrganophotocatalytic Regioselective C-H Alkylation of Electron-Rich Arenes Using Activated and Unactivated Alkenes, Application of 1,3-Dimethoxybenzene, the main research area is heteroarene activated unactivated alkene carbon hydrogen alkylation regioselective organophotocatalyst; Alkenes; C−H Alkylation; Photocatalysis; Reaction Mechanisms; Regioselectivity.

Direct alkylation of the C-H bond arenes in a selective manner is a long-standing challenge. Herein, a metal-free photocatalytic regioselective C-H alkylation method for electron-rich arenes with both activated and unactivated alkenes was developed. The reaction tolerates a wide range of aromatic rings with diverse substitution patterns, as well as terminal and internal alkenes, providing a general and straightforward metal-free method for C-C bond formation from inert C-H bonds. Moreover, alkynes are also compatible to give the C-H vinylation of electron-rich arenes.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

He, Jing-Yao published the artcilePhotoredox One-Pot Synthesis of 3,4-Dihydroquinolin-2(1H)-ones, Name: 4-Methoxy-N-methylaniline, the main research area is dihydroquinolione preparation; alkene arylamine oxalyl chloride heterocyclization photoredox reaction iridium catalyst.

A photoredox one-pot strategy for efficient accessing 3,4-dihydroquinolin-2(1H)-ones I [R1 = H, Me, OMe, Cl; R2 = Me, Bn, allyl; R3 = H, Me; R4 = C(O)OEt, C(O)Et, S(O)2Ph, etc.; R3R4 = -CH2CH2OC(O)-] from anilines 4-R1C6H4NHR2, oxalyl chloride, and electron-deficient alkenes R3C(=CH2)R4 is disclosed. The new approach features excellent synthetic efficiency, readily available starting materials, and simple operations. It is compatible with a variety of anilines and electron-deficient alkenes. A broad array of 3,4-dihydroquinolin-2(1H)-ones I was prepared

Synlett published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Name: 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bielefeld, Jens published the artcileFast Titanium-Catalyzed Hydroaminomethylation of Alkenes and the Formal Conversion of Methylamine, Category: isoquinoline, the main research area is alkene hydroaminomethylation titanium catalyst methylamine conversion; amines; hydroaminoalkylation; methylamine; phenethylamine; titanium.

The scientific interest in catalytic hydroaminoalkylation reactions of alkenes has vastly increased over the past decade, but these reactions have struggled to become a viable option for general laboratory or industrial use because of reaction times of several days. The titanium-based catalytic system introduced in this work not only reduces the reaction time by several orders of magnitude, into the range of minutes, but the catalyst also is easily available from common starting materials, at a cost of � euro per mmol of catalyst. The authors were also able to formally perform C-H activation of methylamine and achieve coupling to a broad variety of alkenes, through silyl protection of the amine and simple deprotection by water.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Manssen, Manfred published the artcileUreate Titanium Catalysts for Hydroaminoalkylation: Using Ligand Design to Increase Reactivity and Utility, COA of Formula: C8H11NO, the main research area is methylamine alkene ureate titanium catalyst regioselective hydroaminoalkylation green chem; alkylamine prepb.

Herein, an earth-abundant and cost-efficient titanium catalyst generated in situ using com. available Ti(NMe2)4 and a simple to synthesize urea proligand was described. This system demonstrated high TOFs for hydroaminoalkylation with unactivated substrates and features easy to use com. available titanium amido precursors. Addnl., a high catalytic activity, scope of reactivity, and regioselectivity were all demonstrated in the transformation of unactivated terminal olefins with various alkyl and aryl secondary amines. Finally, syntheses of useful amine-containing monomers suitable for the generation of amine-containing materials, as well as amine-containing building blocks for medicinal chem., were disclosed. These preparative methods avoid the necessity of glovebox techniques and were modified to be useful to all synthetic chemists.

ACS Catalysis published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, COA of Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kaper, Tobias published the artcileHydroaminoalkylation/Buchwald-Hartwig amination sequences for the synthesis of benzo-annulated seven-membered nitrogen heterocycles, Computed Properties of 5961-59-1, the main research area is alkene bromophenyl amine titanium hydroaminoalkylation catalyst; aminoalkyl bromobenzene preparation palladium Buchwald Hartwig amination catalyst; azepane preparation.

Reaction sequences consisting of an initial intermol. titanium-catalyzed hydroaminoalkylation of a suitably ortho-bromophenyl-substituted alkene and a subsequent intramol. Buchwald-Hartwig amination are used for the synthesis of benzazepine, benzoxazepine, and benzothiazepine derivatives While in the latter two cases, the hydroaminoalkylation products obtained from an allyl (2-bromophenyl) ether or an allyl (2-bromophenyl) thioether must be purified prior to the subsequent palladium-catalyzed amination step, both reactions can be combined to an efficient one-pot procedure for the synthesis of 2,3,4,5-tetrahydrobenzo[b]azepines when 4-(2-bromophenyl)-1-butene and various N-methylanilines are used as the starting materials.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem