Month: November 2022

Sugihara, Matthew N. published the artcileTiO2-photocatalyzed transformation of the recalcitrant x-ray contrast agent diatrizoate, Recommanded Product: Diatrizoic Acid, the main research area is x ray contrast agent diatrizoate wastewater photocatalytic treatment; diatrizoate wastewater photocatalytic degradation advanced oxidation reductive dehalogenation.

Iodinated x-ray contrast media (ICM) are biol. recalcitrant chems. that are often detected in wastewater-impacted environments at higher concentrations than other pharmaceutical micropollutants of concern. Diatrizoate is an anionic ICM that is especially resistant to conventional wastewater and drinking water treatment processes. This study examined the aqueous photocatalytic treatment of diatrizoate using nanophase titanium dioxide (TiO2). Experiments demonstrated that diatrizoate can be degraded in aqueous TiO2 suspensions illuminated with UV-A light. In oxic solutions, diatrizoate degraded principally via oxidation by adsorbed OH radicals, releasing iodine substituents stoichiometrically, but causing little mineralization of organic C and N. Introduction of OH scavengers significantly slowed the rate of photocatalytic degradation At circumneutral pH, diatrizoate was oxidized much more slowly than iopromide, a nonionic ICM, in part because of unfavorable electrostatic interactions with the neg. charged TiO2 surface; increased rates of oxidation observed at lower pH conditions can be attributed to more favorable diatrizoate-TiO2 sorptive interactions. Experiments also demonstrated that diatrizoate was degraded at appreciable rates in anoxic solutions, and reductive dehalogenation products are identified by liquid chromatog.-mass spectrometry. The higher selectivity of reductive processes suggests a promising strategy for targeted treatment of recalcitrant ICM in organic-rich matrixes like wastewater effluent.

Applied Catalysis, B: Environmental published new progress about Mass spectra (of diatrizoate and transformation products). 117-96-4 belongs to class isoquinoline, name is Diatrizoic Acid, and the molecular formula is C11H9I3N2O4, Recommanded Product: Diatrizoic Acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhou, Cong published the artcilePhotoredox-Catalyzed α-Aminomethyl Carboxylation of Styrenes with Sodium Glycinates: Synthesis of γ-Amino Acids and γ-Lactams, Safety of 4-Methoxy-N-methylaniline, the main research area is arylaminoarylbutanoic acid arylbutyrolactam regioselective preparation; ruthenium photoredox catalyst regioselective aminomethylcarboxylation arylaminoglycine aryl alkene; iridium photoredox catalyst regioselective aminomethylcarboxylation lactamization arylaminoglycine aryl alkene.

A visible-light photoredox-catalyzed reductive α-aminomethyl carboxylation of styrenes and 1,1-diarylalkenes with sodium N-arylglycinates and CO2 has been developed to synthesize a series of α,α-disubstituted γ-amino acids such as MePhNCH2CH2CPh2CO2H and γ-lactams such as 1,3,3-triphenyl-2-pyrrolidinone with high efficiency and regioselectivity. Notably, CO2 released from the decarboxylation step can be reused for the subsequent carboxylation. Distinct from the previous reactions with the same type of substrates leading to simple decarboxylation and olefin hydroalkylation, this process involves addnl. CO2 sequestration, thus leading to olefin α-aminomethyl carboxylation. These findings not only provide new access to α,α-disubstituted γ-amino acids and γ-lactams but also serve as a proof of concept for CO2 reutilization in decarboxylation reactions.

Organic Letters published new progress about Aminomethylation (regioselective, photochem., carboxylation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Kaining published the artcileDehydroxymethylation of Alcohols Enabled by Cerium Photocatalysis, SDS of cas: 104-01-8, the main research area is alc photocatalytic dehydroxymethylation functional group transformation; photocatalytic dehydroxymethylation natural product alkanol functional group transformation.

Dehydroxymethylation, the direct conversion of alc. feedstocks as alkyl synthons containing one less carbon atom, is an unconventional and underexplored strategy to exploit the ubiquity and robustness of alc. materials. Under mild and redox-neutral reaction conditions, utilizing inexpensive cerium catalyst, the photocatalytic dehydroxymethylation platform has been furnished. Enabled by ligand-to-metal charge transfer catalysis, an alc. functionality has been reliably transferred into nucleophilic radicals with the loss of one mol. of formaldehyde. Intriguingly, we found that the dehydroxymethylation process can be significantly promoted by the cerium catalyst, and the stabilization effect of the fragmented radicals also plays a significant role. This operationally simple protocol has enabled the direct utilization of primary alcs. as unconventional alkyl nucleophiles for radical-mediated 1,4-conjugate additions with Michael acceptors. A broad range of alcs., from simple ethanol to complex nucleosides and steroids, have been successfully applied to this fragment coupling transformation. Furthermore, the modularity of this catalytic system has been demonstrated in diversified radical-mediated transformations including hydrogenation, amination, alkenylation, and oxidation

Journal of the American Chemical Society published new progress about Fluorescence. 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lemmens, Vincent published the artcileRu-Bipyridine Entrapped in the Supercages of EMC-1 Faujasite as Catalyst for the Trifluoromethylation of Arenes, Quality Control of 151-10-0, the main research area is hetero arene trifluoromethylation ruthenium bipyridine supercage faujasite catalyst photochem; Ru(bipy)32+; faujasite; heterogeneous catalysis; photocatalysis; trifluoromethylation.

Trifluoromethyl (CF3) groups are versatile structural motifs especially in the field of agrochems. and pharmaceuticals. However, current trifluoromethylation reactions are generally associated with stoichiometric amounts of transition metals/metal oxidants, homogeneous catalysts, high temperatures, and expensive trifluoromethylating agents. In this work, the homogeneous photocatalyst Ru(bipy)32+ is entrapped in the pores of a faujasite support (EMC-1) via a “”ship-in-a-bottle”” strategy. The formation of the coordination compound was confirmed by Fourier transform IR (FTIR), UV-Vis spectroscopy, and X-ray absorption spectroscopy (XAS). Due to its high stability toward acidified environments, this single-site heterogeneous catalyst is suitable for the trifluoromethylation of synthetically interesting (hetero)arenes under visible-light irradiation at room temperature Furthermore, the heterogeneous catalyst could efficiently be reused for at least three times with minimal catalyst leaching/deactivation.

ACS Applied Materials & Interfaces published new progress about Heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Quality Control of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bora, Pranjal P. published the artcileShielding Effect of Micelle for Highly Effective and Selective Monofluorination of Indoles in Water, SDS of cas: 151-10-0, the main research area is indole fluoro bisbenzenesulfonimide water surfactant medium regioselective monofluorination; fluoroindole preparation green chem; arene fluorobenzenesulfonimide water surfactant medium regioselective monofluorination; fluoroarene preparation green chem; E-factor; fluorination; green chemistry; micelles; sustainability.

Highly selective direct monofluorination of indoles and arenes was developed through an approach that allows site-specific solubility of substrate and fluorine source in the micelle. This approach was highly selective for a broad range of substrates with excellent functional group tolerance. Differences in binding constant and solubility of indoles and arenes in the micelle allowed the fine-tuning of selectivity. Control experiments suggested a radical pathway and provided insight into the role of micelles of the environmentally benign amphiphile PS-750-M. Dynamic light scattering experiments strongly indicated the site-specific solubility of the substrate and fluorine source. The methodol. was successfully adapted to gram scale and the E-factor established from a recycle study indicated that the process was environmentally responsible and sustainable.

ChemSusChem published new progress about Fluorination, regioselective. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, SDS of cas: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kanemoto, Kazuya published the artcileAcid-Mediated Sulfonylthiolation of Arenes via Selective Activation of SS-Morpholino Dithiosulfonate, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is thiosulfonate preparation regioselective; arene morpholinotoluene dithioperoxosulfonate desulfurilative sulfonylthiolation trifluoro acetic acid.

A trifluoroacetic-acid-mediated desulfurilative sulfonylthiolation of arenes RH (R = 4-methoxyphenyl, thiophen-2-yl, 6-bromo-2-hydroxynaphthalen-1-yl, etc.) using SS-morpholino 4-toluene(dithioperoxo)sulfonate is described. This system is based on selective activation of the morpholino group over the tosyl group of the doubly transformable sulfur surrogate. Mechanistic studies suggested that the reaction proceeds through electrophilic aromatic substitution followed by sulfur extrusion. The wide substrate scope of this reaction and the transformability of the resulting thiosulfonates RSTs enable expeditious access to divergent multifunctionalized sulfides.

Organic Letters published new progress about Bond formation catalysts. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Gao, Hui published the artcileElectrochemical benzylic C-H arylation of xanthenes and thioxanthenes without a catalyst and oxidant, Safety of 1,3-Dimethoxybenzene, the main research area is aryl xanthene preparation; xanthene arene electrochem arylation reaction; arylthioxanthene preparation; arene thioxanthene electrochem arylation reaction.

A catalyst-free and oxidant-free C-H arylation of xanthenes and thioxanthenes I (R1 = H, Me, OH, Cl, etc.; R2 = H, OMe; R3R4 = -CH=CH-CH=CH-; X = O, S) using electrochem. has been developed, which affords a number of cross-coupling products II (R5 = 4-methoxyphenyl, 4-methoxy-3-methylphenyl, 4-methoxy-3,5-dimethylphenyl, 2H-1,3-benzodioxol-5-yl, etc.) in moderate to good yields. This method is atom- and step-economical as it uses cheap and easily available arenes and heteroarenes as partners directly and the C(sp2)-H/C(sp3)-H type cross-coupling reaction.

Organic Chemistry Frontiers published new progress about Arylation. 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tran, Phuong Hoang published the artcileMagnetically recoverable γ-Fe2O3 nanoparticles as a highly active catalyst for Friedel-Crafts benzoylation reaction under ultrasound irradiation, Category: isoquinoline, the main research area is recoverable magnetic iron oxide nanocatalyst preparation surface structure; arene benzoyl chloride iron oxide nanocatalyst Friedel Crafts benzoylation; diaryl ketone regioselective preparation ultrasonication irradiation green chem.

A simple, facile and efficient method was developed for the Friedel-Crafts benzoylation of arenes using magnetic γ-Fe2O3 nanoparticles under solvent-free sonication. The γ-Fe2O3 nanoparticles were used as an efficient and magnetically recoverable catalyst for the synthesis of aromatic ketones in good to excellent yields at room temperature under solvent-free conditions. The reaction occurred with high regioselectivity under mild condition. The magnetic γ-Fe2O3 nanoparticles were economically synthesized in large-scale, easily separated from the reaction mixture by an external magnet and able to be reused several times without significant loss of the catalytic performance, which made them easy application to industrial processes.

Arabian Journal of Chemistry published new progress about Aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Narobe, Rok published the artcilePhotocatalytic Oxidative Iodination of Electron-Rich Arenes, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is arene anthraquinone photocatalyst regioselective oxidative iodination green chem; iodoarene preparation.

A visible-light-mediated oxidative iodination of electron-rich arenes was developed. 2.5 mol% of unsubstituted anthraquinone as photocatalyst were used in combination with elementary iodine, trifluoroacetic acid and oxygen as the terminal oxidant. The iodination proceeded upon irradiation in non- or weakly-electron donating solvents (DCM, DCE and benzene) wherein a spectral window in strongly colored iodine solutions was observed at around 400 nm. The method provided good to excellent yields (up to 98%) and showed excellent regioselectivity and good functional group tolerance (triple bonds, ketone, ester, amide). Moreover, the photo-iodination was also upscaled to a 5 mmol scale (1.1 g). Mechanistic investigations by intermediate trapping and competition experiments indicate a photocatalytic arene oxidation and the subsequent reaction with iodine as a likely mechanistic pathway.

Advanced Synthesis & Catalysis published new progress about Aryl iodides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Abudken, Ahmed M. H. published the artcileFluorinations of unsymmetrical diaryliodonium salts containing ortho-sidearms; influence of sidearm on selectivity, Synthetic Route of 151-10-0, the main research area is arene fluoroiodane fluorination; fluoroarene preparation.

Activated aromatics were reacted with two different fluoroidoane reagents in the presence of triflic acid to prepare only the para-substituted diaryliodonium salts. With fluoroiodane the unsym. diaryliodonium salts contained an ortho-propan-2-ol sidearm, whereas the alc. sidearm was eliminated to form an ortho-styrene sidearm in the reaction with fluoroiodane. Only the diaryliodonium salts containing a styrene sidearm were fluorinated successfully to deliver para-fluorinated aromatics in good yields.

Organic & Biomolecular Chemistry published new progress about Aryl fluorides Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem