Zhou, Cong published the artcilePhotoredox-Catalyzed α-Aminomethyl Carboxylation of Styrenes with Sodium Glycinates: Synthesis of γ-Amino Acids and γ-Lactams, Safety of 4-Methoxy-N-methylaniline, the main research area is arylaminoarylbutanoic acid arylbutyrolactam regioselective preparation; ruthenium photoredox catalyst regioselective aminomethylcarboxylation arylaminoglycine aryl alkene; iridium photoredox catalyst regioselective aminomethylcarboxylation lactamization arylaminoglycine aryl alkene.
A visible-light photoredox-catalyzed reductive α-aminomethyl carboxylation of styrenes and 1,1-diarylalkenes with sodium N-arylglycinates and CO2 has been developed to synthesize a series of α,α-disubstituted γ-amino acids such as MePhNCH2CH2CPh2CO2H and γ-lactams such as 1,3,3-triphenyl-2-pyrrolidinone with high efficiency and regioselectivity. Notably, CO2 released from the decarboxylation step can be reused for the subsequent carboxylation. Distinct from the previous reactions with the same type of substrates leading to simple decarboxylation and olefin hydroalkylation, this process involves addnl. CO2 sequestration, thus leading to olefin α-aminomethyl carboxylation. These findings not only provide new access to α,α-disubstituted γ-amino acids and γ-lactams but also serve as a proof of concept for CO2 reutilization in decarboxylation reactions.
Organic Letters published new progress about Aminomethylation (regioselective, photochem., carboxylation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Safety of 4-Methoxy-N-methylaniline.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem