Month: November 2022

Wang, Jing-Hao published the artcileThiol Activation toward Selective Thiolation of Aromatic C-H Bond, Name: 1,3-Dimethoxybenzene, the main research area is thiophenol aryl ether regioselective electrochem thiolation; diaryl thioether preparation.

An effective model for regioselective thiolation of the aromatic C-H bond by thiol activation instead of arene activation was disclosed. This method was applied into anisole derivatives that are not available in the arene activation approach to forge a single thioether isomer with high reactivity.

Organic Letters published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Matsukawa, Yuta published the artcileReactions between 5-Nitroso-1,3-diphenyltetrazolium Salts and Electron-Rich Arenes, Amines, Thiophenol, Sulfoxides, and Thioanisole, Product Details of C8H10O2, the main research area is nitroso diphenyltetrazolium salt arene amine thiophenol sulfoxide thioanisole oxidation.

A series of reactions between 5-nitroso-1,3-diphenyltetrazolium tetrafluoroborate and methoxybenzenes such as 1,3,5-trimethoxybenzene, 1,3-dimethoxybenzene, methoxybenzene, amines such as aniline, N,N’-bianiline, benzhydrylamine, benzylamine, thiols (thioanisole, thiophenol), sulfoxides (DMSO, di-Ph sulfoxide) and di-Ph sulfide, most of which are generally accepted as being inert to nitroso groups, is reported here. The tetrazolium-activated nitroso functionality is capable of oxidizing the aforementioned substrates to give the corresponding oxidized products e.g., azobenzene, and the nitroso tetrazolium itself is transformed into the corresponding amide or hydroxyamide I [R = NH-, O-], depending on the nature of the reaction partners. In the case of thioanisole, an addition product II•BF4- was obtained.

Bulletin of the Chemical Society of Japan published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Meng, Jing published the artcileSelective N-monomethylation of primary anilines with the controllable installation of N-CH2D, N-CHD2, and N-CD3 units, Formula: C8H11NO, the main research area is aniline monomethylation.

The selective N-monomethylation of primary anilines was realized using the Me3N-BH3/N,N-dimethylformamide (DMF) system as the Me source. This method also allows for the controllable introduction of N-CH2D, N-CHD2, and N-CD3 units with high levels of deuterium incorporation using Me3N-BH3/d7-DMF, Me3N-BD3/DMF and Me3N-BD3/d7-DMF systems, resp.

Organic & Biomolecular Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Formula: C8H11NO.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Fu, Aixiao published the artcileSelective N-Monomethylation of Amines and Nitroarenes using Methanol over an Encapsulated Iridium Nanocatalyst, Computed Properties of 5961-59-1, the main research area is methyl amine green preparation; amine methanol selective monomethylation encapsulated iridium nanocatalyst; nitroarene methanol selective monomethylation encapsulated iridium nanocatalyst.

A highly selective N-monomethylation of aniline and nitrobenzene using methanol as methylating reagent was achieved with high efficiency when using an encapsulated iridium nanocatalyst. A wide range of amines and nitro compounds reacted well in the established catalytic system with moderate to excellent product yields and good functional group tolerance. The transfer hydrogenation and successive cyclization coupling reaction of ortho-phenylenediamine with methanol to afford benzimidazole and N-methylbenzimidazole was also efficiently realized under moderate reaction conditions. Recycling experiments showed that the iridium nanocatalyst had a good stability without obvious activity loss.

Asian Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhang, Zhong-Wei published the artcileEfficient Synthesis of 7H-Chromeno[3,2-c]quinolin-5-ium Salts and Quinolin-4-ones through Acid-Promoted Cascade Reaction of 3-Formylchromones and Anilines, Synthetic Route of 5961-59-1, the main research area is hydroxybenzoyl quinolinone preparation; chromenoquinolinium salt preparation green chem ring opening; formylchromone tandem cycloaddition oxidation aniline.

The authors report an efficient and environment-friendly approach for the synthesis of multisubstituted 7-oxo-7H-chromeno[3,2-c]quinolin-5-ium salts I [R1 = H, F, Cl, Me, Br, R2 = Me, Et, R3 = NO2, iso-Pr, OPh, etc.] using ambient air as a green sole oxidant. I were prepared through metal-free cascade intermol. cycloaddition/oxidation reaction of 3-formylchromones II and N-substituted anilines 4-R3C6H4NHR2 using HClO4 as the reagent and promoter under concise one-pot conditions. In the applied research, the resulting quinolinium salts I could serve as synthons and could be further transformed into diverse synthetically useful 3-(2-hydroxybenzoyl)quinolin-4-ones III in water. This protocol offers a simple cascade strategy to synthesize a wide variety of natural-like chromeno[3,2-c]quinolin-5-ium salts and quinolin-4-ones, and demonstrates academic research potential as well as industrial applications.

ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sole, Daniel published the artcileIron-promoted dealkylative carbene aminocyclization of δ-arylamino-α-diazoesters, Synthetic Route of 5961-59-1, the main research area is aryl proline preparation; arylamino diazoester preparation aminocyclization iron catalyst.

Herein, a novel methodol. to access N-aryl proline derivatives I (R = Ph, 2,4-dimethylphenyl, naphthalen-1-yl, etc.; R1 = Me, Et) using amino-tethered α-diazoesters RN(R2)(CH2)3C(=N2)C(O)OR1 [R2 = Me, Et, i-Pr, t-Bu, Bn] and cheap, readily available iron salts were reported. Mechanistically, the aminocyclization reaction involves the initial formation of an iron-carbene complex followed by a nucleophilic attack of the aniline nitrogen atom to give an ammonium ylide intermediate, which finally undergoes the iron-promoted dealkylation.

Dalton Transactions published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Cao, An-Zhu published the artcileCopper-catalyzed C-H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides via C(sp3)-Br/C(sp2)-H functionalization, HPLC of Formula: 5961-59-1, the main research area is oxindole preparation; aniline carbonyl alkyl bromide annulation copper catalyst.

A copper-catalyzed C-H [3 + 2] annulation of N-substituted anilines with α-carbonyl alkyl bromides for the synthesis of 3,3′-disubstituted oxindoles is developed. Tandem C-H cycloamidation reactions of various α-carbonyl alkyl bromide derivatives including tertiary-α-bromoalkyl ketone esters, malonic esters and cycloalkanes, with N-aryl or alkyl substituted anilines, can be performed using this system, affording a vast array of valuable 3,3′-disubstituted oxindoles in moderate to good yields.

Organic & Biomolecular Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Maddila, Suresh published the artcileMicrowave-Assisted Multicomponent Reaction: A Green and Catalyst-Free Method for the Synthesis of Poly-Functionalized 1,4-Dihydropyridines, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is benzaldehyde aniline malononitrile dimethylacetylenedicarboxylate multicomponent reaction microwave irradiation; dimethyl phenyl phenyldihydropyridinedicarboxylate preparation green chem.

A facile and an efficient procedure for the synthesis of poly-substituted 1,4-dihydropyridine derivatives under catalyst-free conditions was established by a one-pot multi-component reaction in EtOH solvent under microwave irradiation (150 W). The remarkable benefits of this approach were: simple operation, non-toxic, short reaction time (< 5 min), excellent yields (93-98%), no column chromatog., clean reaction profile and environmentally friendly reaction. ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, He published the artcileIntermolecular diastereoselective annulation of azaarenes into fused N-heterocycles by Ru(II) reductive catalysis, Category: isoquinoline, the main research area is fused nitrogen heterocycle compound preparation chemoselective diastereoselective; azaarenium salt aniline paraformaldehyde dearomative annulation; ruthenium reductive catalysis.

Derivatization of azaarenes can create mols. of biol. importance, but reductive functionalization of weakly reactive azaarenes remains a challenge. Here the authors show a dearomative, diastereoselective annulation of azaarenes, via ruthenium(II) reductive catalysis, proceeding with excellent selectivity, mild conditions, and broad substrate and functional group compatibility. Mechanistic studies reveal that the products are formed via hydride transfer-initiated β-aminomethylation and α-arylation of the pyridyl core in the azaarenes, and that paraformaldehyde serves as both the C1-building block and reductant precursor, and the use of Mg(OMe)2 base plays a critical role in determining the reaction chemoselectivity by lowering the hydrogen transfer rate. The present work opens a door to further develop valuable reductive functionalization of unsaturated systems by taking profit of formaldehyde-endowed two functions.

Nature Communications published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Huai-Bo published the artcileElectrochemical Synthesis of Benzimidazoles via Dehydrogenative Cyclization of Amidines, HPLC of Formula: 5961-59-1, the main research area is aryl amidine electrochem dehydrogenative cyclization; phenyl benzoimidazole preparation; C−H functionalization; amidine; electrochemical synthesis; oxidation; radical cyclization.

The development of efficient and sustainable methodologies for the synthesis of N-heterocycles was a constant focus of organic synthesis. An electrochem. method was reported for the synthesis of benzimidazoles through dehydrogenative cyclization of easily available N-aryl amidines. The reactions were conducted under simple constant current conditions in an undivided cell without need for catalysts, chem. oxidants, or additives, and produced H2 as the only theor. byproduct.

ChemSusChem published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem