Month: November 2022

Kaper, Tobias published the artcileHydroaminoalkylation/Buchwald-Hartwig amination sequences for the synthesis of benzo-annulated seven-membered nitrogen heterocycles, Computed Properties of 5961-59-1, the main research area is alkene bromophenyl amine titanium hydroaminoalkylation catalyst; aminoalkyl bromobenzene preparation palladium Buchwald Hartwig amination catalyst; azepane preparation.

Reaction sequences consisting of an initial intermol. titanium-catalyzed hydroaminoalkylation of a suitably ortho-bromophenyl-substituted alkene and a subsequent intramol. Buchwald-Hartwig amination are used for the synthesis of benzazepine, benzoxazepine, and benzothiazepine derivatives While in the latter two cases, the hydroaminoalkylation products obtained from an allyl (2-bromophenyl) ether or an allyl (2-bromophenyl) thioether must be purified prior to the subsequent palladium-catalyzed amination step, both reactions can be combined to an efficient one-pot procedure for the synthesis of 2,3,4,5-tetrahydrobenzo[b]azepines when 4-(2-bromophenyl)-1-butene and various N-methylanilines are used as the starting materials.

Tetrahedron published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Computed Properties of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yang, Ji published the artcileA Selective and General Cobalt-Catalyzed Hydroaminomethylation of Olefins to Amines, HPLC of Formula: 5961-59-1, the main research area is selective cobalt catalyst hydroaminomethylation olefin amine; amines; carbonylation; catalysis; cobalt; ligand design.

A new cobalt catalyst is presented for the domino hydroformylation-reductive amination reaction of olefins. The optimal Co-tert-BuPy-Xantphos catalyst shows good to excellent linear-to-branched (n/iso) regioselectivity for the reactions of aliphatic alkenes with aromatic amines under mild conditions. This system is far more selective than traditional cobalt(I) catalysts and even better than most known rhodium catalysts.

Angewandte Chemie, International Edition published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, HPLC of Formula: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Zhuo published the artcile4-Aminobenzotriazole (ABTA) as a removable directing group for palladium-catalyzed aerobic oxidative C-H olefination, SDS of cas: 104-01-8, the main research area is cyclic peptide synthesis crystal structure aminobenzotriazole directing group; benzotriazole alkylation arylation; aerobic oxidative olefination palladium catalyst macrocyclization peptidomimetic.

4-Aminobenzotriazole (ABTA) was applied as an effective removable directing group (DG) in Pd-catalyzed C-H activation for the first time. Compared with the widely applied pyridine and quinoline analogs, ABTA showed significantly improved reactivity, achieving aerobic oxidative C-H olefination in excellent yields (up to 95% vs <50% with other reported DGs under identical conditions). Using this new strategy, macrocyclization was achieved to give cyclic peptides in good yields with easy ABTA removal under mild conditions, highlighting the promising potential of this new DG. Organic Letters published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ouyang, Wensen published the artcileModular construction of functionalized anilines via switchable C-H and N-alkylations of traceless N-nitroso anilines with olefins, Related Products of isoquinoline, the main research area is functionalized aniline preparation chemoselective regioselective; nitroso aniline olefin alkylation rhodium catalyst.

A switchable C-H alkylation and N-alkylation with great chemo- and site-selectivity enabled by N-nitroso anilines was developed, affording functionalized anilines, hydrazines and heterocycles. The exploration of strain-release as the key driving force with structurally diverse olefins enabled mild and practical sequential C-H and C-C or C-O cleavage. Notably, N-nitroso anilines could act as traceless directing groups to enable indole synthesis via dehydrogenative coupling with styrenes.

Organic Chemistry Frontiers published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Saadati, Fariba published the artcileGuanidinate Early-Transition-Metal Complexes: Efficient and Selective Hydroaminoalkylation of Alkenes, SDS of cas: 5961-59-1, the main research area is tantalum methylamido silylmethyl complex catalyst hydroaminoalkylation alkene; crystal structure methylamido silylmethyl triazabicyclodecene tantalum complex; mol structure methylamido silylmethyl triazabicyclodecene tantalum complex.

The influence of N,N-chelating guanidinate ligands on the reactivity of in situ generated Ta complexes for the intermol. hydroaminoalkylation of amines were explored. Increased conversion was observed with the Na salt of 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBDNa) paired with the Ta precursor Ta(CH2SiMe3)3Cl2 at 110°. Terminal alkenes underwent hydroaminoalkylation with a variety of secondary amine substrates to give substituted secondary amine products. Mono- and bis(guanidinate) Ta complexes were prepared, and their structures were studied. Importantly, the guanidinate ligand could be alkylated in the β position using Ta(NMe2)5 as a precatalyst to give the linear regioisomer as the major product, and this substituted ligand gave improved hydroaminoalkylation conversion in comparison to the parent ligand.

Organometallics published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Lin, Zhiyang published the artcileSynthesis of gem-Difluoroalkenes via Nickel-Catalyzed Reductive C-F and C-O Bond Cleavage, Product Details of C11H12O3, the main research area is alkene trifluoromethyl acetal nickel allylic defluorinative coupling reaction catalyst; difluoroalkene preparation.

By merging C-O and C-F bond cleavage in cross-electrophile coupling, we developed a method for efficient synthesis of gem-difluoroalkenes with an alkoxy-substituent on the homoallylic position using easily accessible acetals as coupling partners with α-trifluoromethyl alkenes. Remarkably, this Ni-catalyzed allylic defluorinative cross-coupling reaction demonstrates high tolerance of a wide range of sensitive functional groups and proves to be applicable in late-stage functionalization of structurally complex compounds

ACS Catalysis published new progress about Acetals Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Product Details of C11H12O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Abdelhamid, Yusra published the artcileIsothiourea-Catalyzed [2+2] Cycloaddition of C(1)-Ammonium Enolates and N-Alkyl Isatins, Recommanded Product: 4-Methoxyphenylacetic acid, the main research area is beta hydroxyamide preparation diastereoselective enantioselective; alkyl isatin anhydride ammonium enolate cycloaddition ring opening isothiourea.

Enantioselective [2+2] cycloaddition of C(1)-ammonium enolates generated catalytically using the isothiourea HyperBTM with N-alkyl isatins gives spirocyclic β-lactones. In situ ring-opening with an amine nucleophile generates isolable highly enantioenriched products I (R1 = H, 6-Cl, 5-OCF3, etc.; R2 = Me, Bn, allyl; R3 = Ph, 4-MeOC6H4, 1-naphthyl, etc.; Nuc = NHCH2C6H5, N-morpholinyl, N-pyrrolidinyl) in up to 92:8 dr and in >99:1 er.

Organic Letters published new progress about [2+2] Cycloaddition reaction catalysts (stereoselective). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Recommanded Product: 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Calva-Estrada, S. J. published the artcileThermal properties and volatile compounds profile of commercial dark-chocolates from different genotypes of cocoa beans (Theobroma cacao L.) from Latin America, Name: 5-Methyl-2-phenylhex-2-enal, the main research area is Theobroma cacao thermal property volatile compound dark chocolate genotype; 2,3-Butanediol (PubChem CID 262); 2-Methylpropanoic acid (PubChem CID 6590); 2-Nonanone (PubChem CID 13187); 2-Phenylethyl acetate (PubChem CID 7654); 2-Phenylethyl alcohol (PubChem CID 6054); 3-Methyl-butanal (PubChem CID 11552); Benzaldehyde (PubChem CID 240); Chemometrics; Differential scanning calorimetry; Furfural (PubChem CID 7362); Hierarchical cluster analysis heatmap; Polymorphism; Principal component analysis; Tetramethylpyrazine (PubChem CID 14296); Trimethylpyrazine (PubChem CID 26808).

There is a growing interest in the identification of chemometric markers that allow the distinction and authentication of dark-chocolates according to their cocoa geog. origin and/or genotype. However, samples derived from Latin American cocoa, including specimens from North and South America, have not been studied in this context. An exploration of the melting behavior, fat composition, bioactive content, and volatile profile of com. darkchocolates was conducted to identify possible patterns related to the genotype and/or origin of cocoa from Latin America. The melting properties were evaluated by DSC and related to fat content and fatty acids profile. Total polyphenol, anthocyanin, methylxanthine, and catechin content were analyzed. Finally, the volatile compounds were extracted and identified by HS-SPME/GC-MS and were analyzed through Principal Component Anal. (PCA) and the Hierarchical Cluster Anal. Heatmap (HCA Heatmap). The fatty acids profile showed a relationship with the melting properties of dark chocolate. The samples exhibited two glass-transition temperatures (Tg) at 19°C and 25.5°C, possibly related to traces of unstable polymorphic forms of monounsaturated triacylglycerides. The anal. of bioactive compounds demonstrated great variability among samples independent of the cocoa origin, genotype, and content. The PCA and HCA Heatmaps allowed discriminating against the chocolates in relation to the cocoa origin and genotype. Compounds like tetramethylpyrazine, trimethylpyrazine, benzaldehyde, and furfural could be considered as dark-chocolate aroma markers derived from Latin American cocoas (North American region). The 2-phenylethyl alc., 2-methylpropanoic acid, 2,3-butanediol, 2-nonanone, and limonene for derived from South America. And the 2-phenylethyl acetate, 3-methyl-butanal, and cinnamaldehyde could allow to distinguishing between regional genotypes.

Food Research International published new progress about Anthocyanins Role: ANT (Analyte), ANST (Analytical Study). 21834-92-4 belongs to class isoquinoline, name is 5-Methyl-2-phenylhex-2-enal, and the molecular formula is C13H16O, Name: 5-Methyl-2-phenylhex-2-enal.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Sukowski, Verena published the artcileS,O-Ligand-Promoted Pd-Catalyzed C-H Olefination of Anisole Derivatives, Name: 1,3-Dimethoxybenzene, the main research area is anisole olefination palladium catalyst.

The C-H olefination of substituted anisole derivatives by a Pd/S,O-ligand catalyst is reported. The reaction proceeds under mild conditions with a broad range of substituted aryl ethers bearing both electron donating and withdrawing substituents at ortho, meta and para positions. Aryl ethers are used as limiting reagents and good yields and site selectivities are observed The methodol. is operationally simple and can be performed under aerobic conditions.

European Journal of Organic Chemistry published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tu, Guangliang published the artcileLigand-Promoted Nickel-Catalyzed para-Selective Carboxylation of Anisoles, Recommanded Product: 1,3-Dimethoxybenzene, the main research area is anisole regioselective carboxylation bromoform radical nickel catalyst.

It has always been a challenge in free radical chem. to control site selectivity during the reaction of free radicals with aromatic rings. Herein, the site-selective carboxylation of anisoles through the direct reaction of the bromoform radical with a benzene ring at the para position under the assistance of 2,9-dimethyl-4,7-diphenyl-1,10-phenanthroline with nickel(II) as the catalyst is reported. A wide variety of anisoles were compatible, leading to para-carboxylated products in moderate to good yields. A preliminary mechanistic study suggested that the Ni(II) complex coordinates with the methoxyl group of the aromatic ring, which may have increased the steric hindrance at the ortho and meta positions, while this weak interaction reduces the aromaticity of the aromatic ring, affording an activated Ph ring, thereby leading to highly para-selective carboxylation.

Organic Letters published new progress about Anisoles Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Recommanded Product: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem