Zhang, Zhong-Wei published the artcileEfficient Synthesis of 7H-Chromeno[3,2-c]quinolin-5-ium Salts and Quinolin-4-ones through Acid-Promoted Cascade Reaction of 3-Formylchromones and Anilines, Synthetic Route of 5961-59-1, the main research area is hydroxybenzoyl quinolinone preparation; chromenoquinolinium salt preparation green chem ring opening; formylchromone tandem cycloaddition oxidation aniline.
The authors report an efficient and environment-friendly approach for the synthesis of multisubstituted 7-oxo-7H-chromeno[3,2-c]quinolin-5-ium salts I [R1 = H, F, Cl, Me, Br, R2 = Me, Et, R3 = NO2, iso-Pr, OPh, etc.] using ambient air as a green sole oxidant. I were prepared through metal-free cascade intermol. cycloaddition/oxidation reaction of 3-formylchromones II and N-substituted anilines 4-R3C6H4NHR2 using HClO4 as the reagent and promoter under concise one-pot conditions. In the applied research, the resulting quinolinium salts I could serve as synthons and could be further transformed into diverse synthetically useful 3-(2-hydroxybenzoyl)quinolin-4-ones III in water. This protocol offers a simple cascade strategy to synthesize a wide variety of natural-like chromeno[3,2-c]quinolin-5-ium salts and quinolin-4-ones, and demonstrates academic research potential as well as industrial applications.
ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem