Month: November 2022

Weber, Stefan published the artcileSelective Hydrogenation of Aldehydes Using a Well-Defined Fe(II) PNP Pincer Complex in Biphasic Medium, Related Products of isoquinoline, the main research area is aldehyde selective hydrogenation iron pincer complex catalyst ionic liquid; Hydrogenation; aldehydes iron; biphasic catalysis; ionic liquids; pincer complexes.

A biphasic process for the hydrogenation of aldehydes was developed using a well-defined iron (II) PNP pincer complex as model system to investigate the performance of various ionic liquids A number of suitable hydrophobic ionic liquids based on the N(Tf)2- anion were identified, allowing to immobilize the iron (II) catalyst in the ionic liquid layer and to facilitate the separation of the desired alcs. Further studies showed that targeted Bronsted basic ionic liquids can eliminate the need of an external base to activate the catalyst.

ChemCatChem published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Ribeiro Gouveia, Liana published the artcileWell-Defined ENENES Re and Mn Complexes and Their Application in Catalysis: The Role of Potassium tert-Butoxide, Application In Synthesis of 86-51-1, the main research area is rhenium complex bidentate thienyldiamine ligand preparation catalyst aldehyde hydrogenation; manganese complex bidentate thienyldiamine ligand preparation catalyst aldehyde hydrogenation; crystal structure rhenium carbonyl complex bidentate thienyldiamine ligand; mol structure rhenium carbonyl complex bidentate thienyldiamine ligand.

A new family of air-stable Re and Mn complexes bearing bidentate NNS (ENENES) ligands E(CH2)2NH(CH)2SR (E = -NC4H8O or -NC5H10, R = Ph or thiophenyl) is introduced. All Re and Mn complexes were catalysts for the hydrogenation of aldehydes. The Mn catalysts were active at milder conditions. A Re-hydride complex, featuring cis Re-H and N-H moieties, was isolated to provide an insight into the mechanism for this reaction. DFT (B3PW91-D3) and probably there are two pathways for this system, with and without the presence of the base (t-BuOK). The pathway that included t-BuOK was lower in energy, providing a greater driving force for the overall reaction.

Organometallics published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application In Synthesis of 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Harenberg, Johannes H. published the artcilePreparation of Functionalized Aryl, Heteroaryl, and Benzylic Potassium Organometallics Using Potassium Diisopropylamide in Continuous Flow, Name: 1,3-Dimethoxybenzene, the main research area is metalation continuous flow generation organopotassium aromatic hetaryl nucleophile; electrophile addition coupling organopotassium aromatic heterocyclic compound; alc ketone thioether silane preparation organopotassium nucleophile addition coupling; arenes; flow chemistry; heteroarenes; lateral metalation; potassium.

Heterocyclic and aromatic compounds were metalated by lithium-free potassium diisopropylamide serving as nucleophiles in carbonyl group addition and coupling reactions, providing access to versatile substituted benzothiazoles, benzothiophenes, benzofurans and functionalized aromatic compounds We report the preparation of lithium-salt-free KDA (potassium diisopropylamide; 0.6 M in hexane) complexed with TMEDA (N,N,N’,N’-tetramethylethylenediamine) and its use for the flow-metalation of (hetero)arenes between -78° and 25° with reaction times between 0.2 s and 24 s and a combined flow rate of 10 mL min-1 using a com. flow setup. The resulting potassium organometallics react instantaneously with various electrophiles, such as ketones, aldehydes, alkyl and allylic halides, disulfides, Weinreb amides, and Me3SiCl, affording functionalized (hetero)arenes in high yields. This flow procedure is successfully extended to the lateral metalation of methyl-substituted arenes and heteroaromatics, resulting in the formation of various benzylic potassium organometallics. A metalation scale-up was possible without further optimization.

Angewandte Chemie, International Edition published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Salgin-Goksen, Umut published the artcileNew 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors, Recommanded Product: 2,3-Dimethoxybenzaldehyde, the main research area is benzoxazolinoneyl acetyl pyrazoline preparation monoamine oxidase ADMET human SAR; phenylallylidene benzoxazolinoneyl acetohydrazide preparation mol docking ADME antitumor.

Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazolines I [R1 = H, Me, Cl; R2 = H, 4-Me, 4-OMe, 2-OMe, 3-OMe; R3= H, 4-Me, 3-OMe, etc.] structure and nine compounds N’-(1,3-disubstitutedphenylallylidene)-2-(5-substituted-2-benzoxazolinone-3-yl)acetohydrazides II [R1 = H, Me, Cl; R2 = H, 2-OMe, 4-OMe, 2-OMe; R3 = H, 2-OMe, 3-OMe, 2-Cl, 2,3-di-OMe] were synthesized and evaluated as monoamine oxidase (MAO) inhibitors. All of the compounds I and II exhibited selective MAO-A inhibitor activity in the nanomolar or low micromolar range. The results of the mol. docking for hydranone derivatives II supported the in vitro results. Compounds, I [R1 = R2 = H, R3 = 4-Me] (0.008μM, selectivity index (SI): 9.70 x 10-4), I [R1 = R2 =H, R3 = 3,4-di-OMe] (0.009μM, SI: 4.55 x 10-5), I [R1 = H, R2 = 4-OMe, R3 = 2-Cl] (0.001μM, SI: 8.00 x 10-4), I [R1 = Me, R2 = 4-OMe, R3 = 2,3-di-OMe] (0.009μM, SI: 1.37 x 10-5) and II [R1= Cl, R2 = 4-OMe, R3 = 2,3-di-OMe] (0.010μM, SI: 5.40 x 10-6), exhibiting the highest inhibition and selectivity toward hMAO-A and nontoxic to hepatocytes were assessed for antidepressant activity as acute and subchronic in mice. All of these five compounds showed significant antidepressant activity with subchronic administration consistent with the increase in the brain serotonin levels and the compounds crossed the blood-brain barrier according to parallel artificial membrane permeation assay. Compounds I [R1 = H, Me, Cl; R2 = 4-OMe, R3 = 2-Cl, 2,3-di-OMe] exhibited an ex vivo MAO-A profile, which was highly consistent with the in vitro data.

Journal of Medicinal Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Recommanded Product: 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Tank, Manishkumar J. published the artcileSynthesis and biological activities of Chalcone and Pyrimidine derivatives of imidazothiadiazole moiety, Application In Synthesis of 104-01-8, the main research area is imidazothiadiazolyl phenylpropenyl chromenone preparation antibacterial antifungal antitubercular antimalarial activity; pyrimidinyl imidazothiadiazolyl chromenone preparation antibacterial antifungal antitubercular antimalarial activity.

Target mols. based on imidazothiazole-chalcone derivatives I (R1 = H, OH, NO2, MeO; R2 = H, OH, NO2, MeO, Br, Cl, Me) and imidazothiazole-pyrimidine derivatives II were synthesized. Chalcone series of compounds I was synthesized by reaction between 2-(4-methoxybenzyl)-6-(2-oxo-2H-chromen-3-yl)imidazo[2,1-b][1,3,4]thiadiazole-5-carbaldehyde and various substituted acetophenones 4-R2-3-R1C6H3C(O)Me and these chalcones I were converted into pyrimidine series II. These derivatives of chalcones and pyrimidine were examined in vitro for antimicrobial and antifungal activities against clin. isolated strains and their characterization was confirmed by FTIR, 1H-NMR, 13C and LCMS.

Chemistry & Biology Interface published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application In Synthesis of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Bayrak, Cetin published the artcileMonodisperse NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as a catalyst for the highly efficient chemoselective reduction of α,β-unsaturated ketone compounds, Category: isoquinoline, the main research area is diphenyl propanone preparation chemoselective; chalcone transfer hydrogenation nickel palladium alloy nanoparticle catalyst preparation.

The study of extraordinary chemoselective reduction with selectivity (>99%) by the catalytic transfer hydrogenation of various α,β-unsaturated ketones RC(O)CH=CHR1 (R = 4-methylphenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl; R1 = 2,3-dimethoxyphenyl, 4-methylphenyl, 4-methoxyphenyl, 2,4-dimethoxyphenyl, 3,4,5-trimethoxyphenyl) with a catalyst of NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride (NiPd/mpg-C3N4) under mild conditions in a water/methanol medium was reported. NiPd alloy NPs were synthesized by the reduction of metal salts in oleylamine (OAm) solution with the help of borane-tert-butylamine and then decorated on mpg-C3N4 via a liquid phase self-assembly method. The NiPd/mpg-C3N4 nanocatalyst is a highly active catalyst for the chemoselective reduction of α,β-unsaturated ketones and all organic compounds were converted with high yield and 99% selectivity. In addition, the catalyst can be reused five times without an important loss in reaction yield.

New Journal of Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Mingsheng published the artcileSynthesis, characterization, and DRAK2 inhibitory activities of hydroxyaurone derivatives, Safety of 2,3-Dimethoxybenzaldehyde, the main research area is hydroxyaurone preparation DRAK2 inhibitor SAR.

Authors reported the synthesis of 25 derivatives of hydroxyaurone which were characterized by 1H NMR, 13C NMR, high resolution mass spectrum, and single crystal X-ray diffraction anal. Their activities on the death-associated protein kinase-related apoptosis-inducing kinase-2 (DRAK2) were evaluated by kinase detection kit at a dosage of 5μM. Most of the synthetic hydroxyaurones exhibited moderate to good inhibitory activities. The IC50 value ranged from 0.81 to 2.42μM when the structure of aurone’s B ring was kept unchanged and its A ring was substituted by hydroxyl groups. On the contrary, modification of the aurone’s B-ring with hydroxyl groups lead to the IC50 value ranging from 1.15 to 17.5μM. This indicates presence of hydroxyl group of the B ring is crucial for aurone’s DRAK2 kinase inhibitors. Therefore, hydroxyaurone may serve as a new possible lead compound for the discovery of DRAK2. Further pharmacol. investigations are underway and will be reported in due course.

Heterocycles published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Safety of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Doan, Son H. published the artcileA New Synthetic Pathway to Triphenylpyridines via Cascade Reactions Utilizing a New Iron-Organic Framework as a Recyclable Heterogeneous Catalyst, SDS of cas: 104-01-8, the main research area is benzenetricarboxylic acid biphenyldicarboxylic iron complex preparation thermal stability crystallinity; phenylacetic acid acetophenone ammonium acetate iron tandem aldol cyclocondensation; triphenyl pyridine preparation.

A new iron-organic framework, VNU-22 ̅{[Fe3(BTC)(BPDC)2].11.97H2O}, constructed from BTC3-, BPDC2-pillars and infinite [Fe3(CO2)7]∞rod SBU, was obtained. The VNU-22 was utilized as a heterogeneous catalyst in the synthesis of 2,4,6-triphenylpyridines via cascade reactions from acetophenones and phenylacetic acids with ammonium acetate as a nitrogen source. The VNU-22 was more active in the cascade reactions than many homogeneous and heterogeneous catalysts. The framework catalyst was recovered and reutilized without an appreciable decline in its performance. To our best knowledge, this synthetic pathway to 2,4,6-triphenylpyridines was not previously reported and would attract interests from the chem. industry.

European Journal of Organic Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, SDS of cas: 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Xiong published the artcileFullerotetrahydroquinolines: TfOH/TsOH · H2O-Mediated One-Pot Two-Step Synthesis and N-Alkylation/Acylation/Carboamidation Reaction, Synthetic Route of 5961-59-1, the main research area is fullerene amine paraformaldehyde alkylation acylation carboamidation toluenesulfonic trifluoromethanesulfonic acid; fullerotetrahydroquinoline one pot preparation.

A series of N-unsubstituted/substituted fullerotetrahydroquinolines without a directly attached nitrogen atom were synthesized in moderate to good yields via a one-pot two-step reaction of [60]fullerene with arylamines and paraformaldehyde in the presence of trifluoromethanesulfonic acid and p-toluenesulfonic acid monohydrate. Aromatic primary amines produce N-unsubstituted fullereotetrahydroquinolines, while aromatic secondary amines give N-substituted fullereotetrahydroquinoline derivatives As precursors, N-unsubstituted fullerotetrahydroquinolines could be further derivatized by the N-alkylation/acylation/carboamidation reactions to produce a large variety of N-substituted fullerotetrahydroquinolines containing Cl, NO2, C(O), and C(O)NH functional groups, which may have applications in the field of perovskite-based solar cells. Plausible reaction pathways for the formation of N-unsubstituted/substituted fullerotetrahydroquinolines were suggested to elucidate the above-mentioned reaction process.

Advanced Synthesis & Catalysis published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, Synthetic Route of 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Barysevich, Maryia V. published the artcilePalladium-Catalyzed 2-(Neopentylsulfinyl)aniline Directed C-H Acetoxylation and Alkenylation of Arylacetamides, Formula: C9H10O3, the main research area is aryl acetamide regioselective acetoxylation diacetoxyiodobenzene palladium catalyst; acetoxy arylacetamide preparation; cyclopropanol stereoselective regioselective alkenylation arylacetamide palladium catalyst; alkenyl arylacetamide preparation.

The 2-(neopentylsulfinyl)aniline directing group that promotes rapid palladium-catalyzed C-H acetoxylation and alkenylation of arylacetamides has been developed. The acetoxylation reached completion within only 40 min at 100°C and led to the bis-functionalized products. Alternatively, the reaction can be carried out at room temperature, which is beneficial for sensitive substrates. For the alkenylation, a protocol has been developed where easily available 1-substituted cyclopropanols were employed as equivalent of vinyl ketones.

European Journal of Organic Chemistry published new progress about Acetates Role: SPN (Synthetic Preparation), PREP (Preparation). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Formula: C9H10O3.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem