Month: November 2022

Smith, Jennifer published the artcileChiral cyclometalated iridium complexes for asymmetric reduction reactions, Application of 2,3-Dimethoxybenzaldehyde, the main research area is iridium reduction transfer hydrogenation cyclometalation iridacycle reductive amination catalyst; ketone pyridinium ion arylamine benzylamine; piperidine secondary amine asym preparation mol structure.

A series of chiral cyclometalated iridium complexes have been synthesized by cyclometalating chiral 2-aryl-oxazoline and imidazoline ligands with [Cp*IrCl2]2. These iridacycles were studied for asym. transfer hydrogenation reactions with formic acid as the hydrogen source and were found to display various activities and enantioselectivities, with the most effective ones affording up to 63% ee in the asym. reductive amination of ketones and 77% ee in the reduction of pyridinium ions.

Organic & Biomolecular Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, Application of 2,3-Dimethoxybenzaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Zhao, Guangkuan published the artcileA Broad Substrate Scope of Aza-Friedel-Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters, Synthetic Route of 151-10-0, the main research area is chloroaminal arene Friedel Crafts alkylation amino ester regioselective preparation.

A versatile synthetic protocol of aza-Friedel-Crafts alkylation has been developed for the synthesis of quaternary α-amino esters. This operationally simple alkylation proceeds under ambient conditions with high efficiency, regioselectivity, and an exceptionally broad scope of arene nucleophiles. A key feature of this alkylation is the role associated with the silver(I) salt counteranions liberated during the reaction. Taking advantage of a phase-transfer counteranion/Bronsted acid pair mechanism, we also report a catalytic enantioselective example of the reaction.

Organic Letters published new progress about Aminals Role: RCT (Reactant), RACT (Reactant or Reagent) (halo). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Synthetic Route of 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yasukawa, Naoki published the artcileGold-Catalyzed Tandem Oxidative Coupling Reaction between β-Ketoallenes and Electron-Rich Arenes to 2-Furylmethylarenes, Product Details of C8H10O2, the main research area is furylmethylarene preparation; ketoallene arene tandem oxidative coupling reaction gold catalyst.

A tandem oxidative coupling reaction of β-ketoallenes R1C(O)CH(R2)CH=C=CH2 (R1 = Ph, n-nonyl, 2-methoxyphenyl, etc.; R2 = H, n-pentyl; R1R2 = -(CH2)4-) and arenes ArH (Ar = 2,4,6-triemthoxyphenyl, 1H-indol-3-yl, 2-methoxy-9-methyl-9H-carbazol-3-yl, etc.) was developed, which leads to the formation of 2-furylmethylarenes I using AuCl3 and phenyliodine diacetate. The AuIII salt catalyzed the cyclization of β-ketoallenes to form a 2-furylmethyl gold intermediate, and the subsequent C-H functionalization of arenes proceeded smoothly. During the oxidative coupling, nucleophilic additions occurred at the center and terminal carbon atoms of the allene moiety to form C-O and C-C bonds.

Organic Letters published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent) (keto). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Campano, Teresa E. published the artcileEnantioselective Addition of Alkynyl Ketones to Nitroolefins Assisted by Bronsted Base/H-Bonding Catalysis, Application of 4-Methoxyphenylacetic acid, the main research area is nitro alkynone preparation diastereoselective enantioselective; alkynyl ketone nitroolefin conjugate addition bifunctional bronsted base catalyst; Brønsted bases; Michael reaction; alkynyl ketones; asymmetric catalysis; organocatalysis.

Various sets of enolizable alkynyl ketones (including Me ynones with α-aryl, α-alkenyl and α-alkoxy groups) were able to react smoothly with nitroolefins with the assistance of bifunctional Bronsted base/H-bond catalysts to provide nitro alkynones with two consecutive tertiary stereocenters I [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R2 = n-Pr, Ph, 2-furyl, etc.; R3 = MeC=CH2, HC=CHPh, Ph, OBn, etc.] in a highly diastereo- and enantioselective fashion. Further transformation of the obtained adducts into optically active acyclic and polycyclic mols., including some with intricate carbon skeletons, was also demonstrated.

Chemistry – A European Journal published new progress about Alkenes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Application of 4-Methoxyphenylacetic acid.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Liu, Shanshan published the artcileDinuclear Zinc-AzePhenol Catalyzed Asymmetric Aza-Henry Reaction of N-Boc Imines and Nitroalkanes under Ambient Conditions, HPLC of Formula: 86-51-1, the main research area is asym aza Henry reaction Boc imine nitroalkane; dinuclear zinc AzePhenol catalyst asym aza Henry reaction.

The asym. aza-Henry reaction of N-Boc imines and nitroalkanes was realized in the presence of 10 mol% dinuclear zinc-AzePhenol catalysts under ambient conditions. A variety of nitroamines were obtained in good yields (up to 97%) with excellent enantioselectivities (up to 99% ee) and high diastereoselectivity (up to 14:1 dr). Our protocol combined the operational simplicity and mild reaction conditions, thus making the process amenable for tech. applications.

Journal of Organic Chemistry published new progress about Alkanes, nitro Role: RCT (Reactant), RACT (Reactant or Reagent). 86-51-1 belongs to class isoquinoline, name is 2,3-Dimethoxybenzaldehyde, and the molecular formula is C9H10O3, HPLC of Formula: 86-51-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Boon, Byron A. published the artcileTriarylaminium Radical Cation Promoted Coupling of Catharanthine with Vindoline: Diastereospecific Synthesis of Anhydrovinblastine and Reaction Scope, Application of 1,3-Dimethoxybenzene, the main research area is anhydrovinblastine diastereoselective synthesis oxidative coupling triarylaminium promoted.

A new triarylaminium radical cation promoted coupling of catharanthine with vindoline is disclosed, enlisting tris(4-bromophenyl)aminium hexachlororantimonate (BAHA, 1.1 equiv) in aqueous 0.05 N HCl/trifluoroethanol (1-10:1) at room temperature (25°C), that provides anhydrovinblastine in superb yield (85%) with complete control of the newly formed quaternary C16′ stereochem. A definition of the scope of aromatic substrates that participate with catharanthine in the BAHA-mediated diastereoselective coupling reaction and simplified indole substrates other than catharanthine that participate in the reaction are disclosed that identify the key structural features required for participation in the reaction, providing a generalized indole functionalization reaction that bears little structural relationship to catharanthine or vindoline.

Journal of the American Chemical Society published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Application of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Xu, Fan published the artcileA general approach to 2,2-disubstituted indoxyls: total synthesis of brevianamide A and trigonoliimine C, Product Details of C8H10O2, the main research area is indoxyl preparation; indole nucleophile coupling; brevianamide A trigonoliimine C total synthesis.

The indoxyl unit is a common structural motif in alkaloid natural products and bioactive compounds Herein, a general method that transforms readily available 2-substituted indoles into 2,2-disubstituted indoxyls via nucleophile coupling with a 2-alkoxyindoxyl intermediate and showcase its utility in short total syntheses of the alkaloids brevianamide A (7 steps) and trigonoliimine C (6 steps) is reported. The developed method is operationally simple and demonstrates broad scope in terms of nucleophile identity and indole substitution, tolerating 2-alkyl substituents and free indole N-H groups, elements beyond the scope of most prior approaches. Spirocyclic indoxyl products are also accessible via intramol. nucleophilic trapping.

Chemical Science published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Product Details of C8H10O2.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Murata, Takumi published the artcileSynthesis of silyl formates, formamides, and aldehydes via solvent-free organocatalytic hydrosilylation of CO2, SDS of cas: 5961-59-1, the main research area is silyl formate formamide aldehyde preparation green chem; organocatalytic hydrosilylation carbon dioxide tetrabutylammonium acetate catalyst green.

Carbon dioxide (CO2) was used as a C1 source to prepare silyl formates, formamides, and aldehydes. Tetrabutylammonium acetate (TBAA) catalyzed the solvent-free N-formylation of amines with CO2 and hydrosilane to give formamides including Weinreb formamide, Me(MeO)NCHO, which was successively converted into aldehydes by one-pot reactions with Grignard reagents.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 5961-59-1 belongs to class isoquinoline, name is 4-Methoxy-N-methylaniline, and the molecular formula is C8H11NO, SDS of cas: 5961-59-1.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Baricelli, Pablo J. published the artcileHydroformylation of natural olefins with the [Rh(COD)(μ-OMe)]2/TPPTS complex in BMI-BF4/toluene biphasic medium: observations on the interfacial role of CTAB in reactive systems, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is aldehyde preparation hydroformylation natural olefin rhodium catalyst ionic liquid.

The complex [Rh(COD)(μ-OMe)]2 in presence of TPPTS (TPPTS = triphenylphosphinetrisulfonate) was evaluated as catalyst precursor for the in situ hydroformylation of natural olefins (eugenol, estragole and safrole) in biphasic media BMIm-BF4/toluene. Under moderate reaction conditions, the substrates showed the following reactivity order: eugenol > estragole > safrole. The rhodium system showed a high activity and selectivity towards the desired aldehydes. It was found that the use of cetyltrimethylammoniun bromide (CTAB) as phase transfer agent inhibits the hydroformylation reaction. The catalytic phase can be recycled up to four times without evident loss of activity or selectivity. In this work we report the use of an ionic liquid with hydrophilic character, without using water in the reaction medium.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Vilches-Herrera, Marcelo published the artcileInfluence of the bite natural angle of bidentate diphosphine ligands in the syngas-free branched hydroformylation of β-functionalized olefins, Application In Synthesis of 1205-17-0, the main research area is bidentate diphosphine ligand branched hydroformylation beta olefin.

The correlation between the activity, regio- and chemoselectivity of Rh-diphosphine catalyst and the ligand bite natural angle (βn) in the syngas-free hydroformylation of allyl cyanide was studied. A screening of Xantphos type and diphosphine alkyl ligands with different bite natural angles was studied. Interesting, a switch in the linear to the branch regioselectivity was found. Wide βn favor a linear regioselectivity whereas smaller βn gave the branched aldehyde as the major product. Modification of the substituents at the phosphorus atoms of the diphosphine ligands produced a dramatic change in the hydroformylation. Others β-functionalized olefins were also branched hydroformylated.

Catalysis Communications published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application In Synthesis of 1205-17-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem