Month: November 2022

Xu, Chao published the artcileFeCl3-catalyzed three-component aryl-selenylation of alkenes, Category: isoquinoline, the main research area is diarylethyl arylselane preparation; alkene aromatic hydrocarbon diselenide three component selenylation iron catalyst.

FeCl3-catalyzed three-component aryl-selenylation of alkenes 4-R-C6H4CH=CH2 (R = H, F, Me, Ph, etc.) with good to excellent yields has been disclosed. This method is characterized by synthesis of complicated products 4-R-C6H4CH(Ar)CH2Se(2-R1-3-R2-4-R3C6H2) [Ar = 2,4,6-trimethoxyphenyl, 2,4-dimethoxyphenyl, 1H-indol-3-yl, etc.; R1 = H, Cl; R2 = H, Me; R3 = H, F, Cl, Br, Me, OMe, CF3] in a single-step reaction, simple operation and readily available com. reagents. Finally, a reasonable mechanism of FeCl3-catalyzed aryl-selenylation is proposed.

Tetrahedron published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Yamada, Tomoyuki published the artcileOxidative Coupling of Benzenes with α,β-Unsaturated Aldehydes by the Pd(OAc)2/Molybdovanadophosphoric Acid/O2 System, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, the main research area is oxidative coupling arene unsaturated aldehyde palladium molybdovanadophosphate catalyst.

The oxidative coupling reaction of benzene with an α,β-unsaturated aldehyde was examined by the combined catalytic system of Pd(OAc)2 with molybdovanadophosphoric acid (HPMoV) under atm. dioxygen. Thus, the reaction of benzene with acrolein under dioxygen (1 atm) by the use of catalytic amounts of Pd(OAc)2 and H4PMo11VO40·26H2O in the presence of dibenzoylmethane as a ligand in propionic acid at 90 °C for 1.5 h afforded cinnamaldehyde in 59% yield and β-phenylcinnamaldehyde in 5% yield. This catalytic system was extended to the direct oxidative coupling through the C-H bond activation of various arenes with acrolein and methacrolein.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1205-17-0 belongs to class isoquinoline, name is 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde, and the molecular formula is C11H12O3, Application of 2-Methyl-3-(3,4-methylenedioxyphenyl)propionaldehyde.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wu, Hongru published the artcileGraphene-Oxide-Catalyzed Cross-Dehydrogenative Coupling of Oxindoles with Arenes and Thiophenols, HPLC of Formula: 151-10-0, the main research area is graphene oxide catalyst dehydrogenative coupling oxindole arene thiophenol.

Here, the authors explore the GO-catalyzed cross-dehydrogenative coupling of oxindoles with arenes and thiophenols for the rapid synthesis of 3-aryloxindoles and 3-sulfenylated oxindoles. Control experiments and small-mol. mimicking studies reveal that the acidic nature and quinone-type functionalities of GO are synergistically used for the coupling reaction. The reaction proceeds under simple and mild reaction conditions, exhibits good functional group tolerance, and can be easily scaled up to the gram level.

Advanced Synthesis & Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Jud, Wolfgang published the artcileCathodic C-H Trifluoromethylation of Arenes and Heteroarenes Enabled by an in Situ-Generated Triflyltriethylammonium Complex, Safety of 1,3-Dimethoxybenzene, the main research area is cathodic fluoromethylation arene heteroarene in situ triflyltriethylammonium complex.

While several trifluoromethylation reactions involving the electrochem. generation of CF3 radicals via anodic oxidation have been reported, the alternative cathodic, reductive radical generation has remained elusive. Herein, the first cathodic trifluoromethylation of arenes and heteroarenes is reported. The method is based on the electrochem. reduction of an unstable triflyltriethylammonium complex generated in situ from inexpensive triflyl chloride and triethylamine, which produces CF3 radicals that are trapped by the arenes on the cathode surface.

Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Safety of 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Wang, Dong published the artcileTrifluoromethyl Sulfoxides: Reagents for Metal-Free C-H Trifluoromethylthiolation, HPLC of Formula: 151-10-0, the main research area is aryl heteroaryl trifluoromethyl thioether regioselective preparation; trifluoromethyl sulfoxide regioselective trifluoromethylthiolation heteroarene mediated triflic anhydride diethylamine; regioselective trifluoromethylation arene trifluoromethyl sulfoxide mediated triflic anhydride diethylamine; ethoxycarbonylmethyl methylphenyl trifluoromethylsulfonium triflate mol crystal structure; Pummerer reaction; arenes; reaction mechanisms; sulfoxides; trifluoromethylthiolation.

Indoles, pyrroles, thiophenes, a benzothiophene, a benzofuran, and arenes underwent metal-free regioselective trifluoromethylthiolation with trifluoromethyl sulfoxides RCH2S(:O)CF3 (R = Ph, EtO2C) mediated by triflic anhydride and diethylamine in acetonitrile or nitromethane to yield heteroaryl and aryl trifluoromethyl thioethers. An aryl(ethoxycarbonylmethyl)(trifluoromethyl)sulfonium triflate was isolated as a trifluoromethylthiolation intermediate and its structure determined by X-ray crystallog., supporting an interrupted Pummerer reaction mechanism for the trifluoromethylthiolation.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, HPLC of Formula: 151-10-0.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Blum, Stephan P. published the artcileMetal-Free Electrochemical Synthesis of Sulfonamides Directly from (Hetero)arenes, SO2, and Amines, COA of Formula: C2H6N2O, the main research area is sulfonamide dehydrogenative electrochem synthesis heteroarene amine; electrochemistry; green chemistry; oxidation; radical reactions; sulfonamides.

Sulfonamides are among the most important chem. motifs in pharmaceuticals and agrochems. However, there is no methodol. to directly introduce the sulfonamide group to a non-prefunctionalized aromatic compound Herein, we present the first dehydrogenative electrochem. sulfonamide synthesis protocol by exploiting the inherent reactivity of (hetero)arenes in a highly convergent reaction with SO2 and amines via amidosulfinate intermediate. The amidosulfinate serves a dual role as reactant and supporting electrolyte. Direct anodic oxidation of the aromatic compound triggers the reaction, followed by nucleophilic attack of the amidosulfinate. Boron-doped diamond (BDD) electrodes and a HFIP-MeCN solvent mixture enable selective formation of the sulfonamides. In total, 36 examples are demonstrated with yields up to 85%.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 598-50-5 belongs to class isoquinoline, name is 1-Methylurea, and the molecular formula is C2H6N2O, COA of Formula: C2H6N2O.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Paul, Sanjay published the artcilePd(TFA)2-Catalyzed direct arylation of quinoxalinones with arenes, Name: 1,3-Dimethoxybenzene, the main research area is aryl quinoxalinone regioselective preparation; quinoxalinone arene cross coupling.

The direct C-3 arylation of quinoxalin-2-ones with arenes was achieved by a Pd(TFA)2-catalyzed cross-dehydrogenative coupling (CDC) reaction. A wide array of functionalities, including highly sensitive allyl- and benzyl group substituted quinoxalin-2(H)-ones I [R = Me, geranyl, Bn, 4-ClBn 4-MeBn; R1 = H, Me, F, Cl, Br, COOMe; R2 = H, Me, F, Cl, Br; R3 = Ph, 2-MeC6H4, 4-FC6H4, etc.], were readily assembled with arenes containing electron-donating and electron-withdrawing groups in this CDC reaction. Highly regioselective products were produced in good yields with stronger electron-donating groups than toluene and densely substituted arenes as coupling partners. This protocol represented an efficient technique to access various 3-arylbenzo[g]quinoxalinones II [R4 = Me, Bn; R5 = Ph, 4-ClC6H4, 4-OMeC6H4] and 2-aryl-4-methylpyrido[3,4-b]pyrazin-3(4H)-ones under mild conditions.

Organic Chemistry Frontiers published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Name: 1,3-Dimethoxybenzene.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Nadeem, Qaisar published the artcileTo Sandwich Technetium: Highly Functionalized Bis-Arene Complexes [99mTc(η6-arene)2]+ Directly from Water and [99mTcO4]-, Computed Properties of 104-01-8, the main research area is technetium sandwich compound preparation; crystal structure bisarene rhenium sandwich compound; mol structure bisarene rhenium sandwich compound; rhenium oxide reaction aromatic compound aqueous solution; aromatic compound reaction technetium oxide aqueous solution; molecular imaging; rhenium; sandwich complexes; screening; technetium.

The labeling of (bio)mols. with metallic radionuclides such as 99mTc demands conjugated, multidentate chelators. However, this is not always necessary since Ph rings can directly serve as integrated, organometallic ligands. Bis-arene sandwich complexes are generally prepared by the Fischer-Hafner reaction. In extension of this, [99mTc(η6-C6R6)2]+-type complexes are directly accessible from H2O and [99mTcO4]-, even using arenes incompatible with Fischer-Hafner conditions. To unambiguously confirm the nature of these unprecedented 99mTc complexes, their Re homologous were prepared by substituting naphthalene ligands in [Re(η6-C10H8)2]+ with the corresponding Ph groups. The ease with which highly stable [99mTc(η6-C6R6)2]+ complexes are formed under standard labeling conditions enables a multitude of new potential imaging agents based on com. pharmaceuticals or lead structures.

Angewandte Chemie, International Edition published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 104-01-8 belongs to class isoquinoline, name is 4-Methoxyphenylacetic acid, and the molecular formula is C9H10O3, Computed Properties of 104-01-8.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Kalaramna, Pratibha published the artcileTransition-Metal-Free HFIP-Mediated Organo Chalcogenylation of Arenes/Indoles with Thio-/Selenocyanates, Category: isoquinoline, the main research area is HFIP mediated chalcogenylation arene indole aryl chalcogenocyanate; chalcogenide synthesis.

We have developed a protocol for the synthesis of diaryl thio-/selenoethers by the reaction of aryl chalcogenocyanates with electron rich arenes/hetero arenes via HFIP promoted C-H activation. The reaction produces chalcogenides in good to excellent yields under mild conditions without the need of a transition metal as a catalyst. The HFIP-mediated reactions tolerated a wide range of functional groups and set the stage for the synthesis of diversely decorated chalcogenides. A mechanism involving activation of the C-H bond through hydrogen bonding is proposed.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Category: isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Rokade, Balaji V. published the artcileSynthesis of α-Aryl-Oxindoles by Friedel-Crafts Alkylation of Arenes, Related Products of isoquinoline, the main research area is arylindole preparation; isatin diethylphosphite arene phospho Brook rearrangement Friedel Crafts reaction.

Synthesis of α-aryl-oxindoles was reported from isatin via a two-step procedure involving a phospha-Brook rearrangement and a Friedel-Crafts alkylation in a one-pot procedure. The use of 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as solvent significantly extended the reaction substrate scope to include relatively less electron rich arenes including benzene. This new alkylation method is fast, straightforward and allows for the direct introduction of the oxindole moiety onto a range of aromatic compounds including phenols. Addnl., the application of arylated products was shown in decarboxylative asym. allylation and protonation.

Journal of Organic Chemistry published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 151-10-0 belongs to class isoquinoline, name is 1,3-Dimethoxybenzene, and the molecular formula is C8H10O2, Related Products of isoquinoline.

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem