Month: February 2023

Efficacy and safety of fasudil in prevention of radial artery spasm during cardiac interventional diagnosis and treatment was written by Zhou, Jing;Gao, Feng;Du, Ri-ying;Bai, Huai-sheng;Li, Xiao-li. And the article was included in Zhongguo Laonianxue Zazhi in 2013.Reference of 105628-07-7 This article mentions the following:

Objective: To observe clin. efficacy of fasudil in prevention of radial artery spasm during cardiac interventional diagnosis and treatment. Methods: 481 cases of hospitalized patients with transradial coronary artery interventional diagnosis and treatment were treated by intrathecal injection of the corresponding drugs for prevention of radial artery spasm. Group I was treated with fasudil 5 mg, groupII was treated with nitroglycerin 200渭g, group III was treated with verapamil 1 mg, and observe whether radial artery spasm occurred and blood pressure, ECG changes, observe whether the local and systemic complications occurred. Results: During transradial intervention treatment, application of fasudil can more effectively prevent the occurrence of radial artery spasm, and has small effect on heart rate, blood pressure and ECG, low incidence of systemic symptoms, and local symptoms. Conclusion: fasudil hydrochloride in cardiac interventional diagnosis and treatment is safe and effective for prevention of radial artery spasm. In the experiment, the researchers used many compounds, for example, 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7Reference of 105628-07-7).

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride (cas: 105628-07-7) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Reference of 105628-07-7

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Perylene dyes with high resistance to alkali was written by Langhals, Heinz;Jaschke, Harald;Bastani-Oskoui, Haleh;Speckbacher, Markus. And the article was included in European Journal of Organic Chemistry in 2005.Formula: C50H62N2O4 This article mentions the following:

The attachment of a 纬-hydroxy alkyl group to a nitrogen atom of perylene-3,4:9,10-tetracarboxylic bisimides results in a persistency to alk. hydrolysis, even to alkali alcoholates. The solubility of these dyes can be controlled by substituents in the 尾-position of the alkyl groups so that either highly stable pigments or dyes for homogeneous solutions with high fluorescence quantum yields are obtained. In the experiment, the researchers used many compounds, for example, 2,9-Di(tridecan-7-yl)anthra[2,1,9-def:6,5,10-d’e’f’]diisoquinoline-1,3,8,10(2H,9H)-tetraone (cas: 110590-84-6Formula: C50H62N2O4).

2,9-Di(tridecan-7-yl)anthra[2,1,9-def:6,5,10-d’e’f’]diisoquinoline-1,3,8,10(2H,9H)-tetraone (cas: 110590-84-6) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.Formula: C50H62N2O4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

UPLC-MS coupled with a dynamic multiple data processing method for the comprehensive detection of the chemical constituents of the herbal formula San-Miao-Wan was written by Zou, Di;Zhang, Ai-hua;Yan, Guang-li;Tan, Yun-long;Sun, Hui;Wang, Xi-jun. And the article was included in Analytical Methods in 2014.Product Details of 3382-18-1 This article mentions the following:

San-Miao-Wan (SMW) is a combination prescription of Cortex Phellodendri Chinensis, Rhizoma Atractylodis, and Radix Achyranthis Bidentatae commonly used to treat arthritis and hyperuricemia, described in the State Pharmacopoeia of the People’s Republic of China. However, despite numerous pharmacol. studies, the phytochem. constituents of SMW were not conclusively identified. In the present study, a universally applicable UPLC-ESI-Q-TOF-MS technique coupled with a multiple data processing approach (Mdpa) was developed to carry out comprehensive detection of the chem. constituents of SMW. The Mdpa method can efficiently deal with the large volumes of mass data collected via the use of spectral and chromatog. search algorithms that detect ions at low concentrations Using an UPLC system, the total anal. time for separation was < 20 min without the loss of any resolution In the principal component anal. VIP-plot, 77 ions of interest (36 ions in pos. mode, 43 ions in neg. mode, and 2 ions in both modes) were extracted Based on the MS fragmentation patterns of the reference standards, a total of 71 components were identified or tentatively characterized by comparing their retention times, UV and MS spectra with those of reference standards, or through the matching of empirical information with those of the published components in the inhouse library. Our results indicated that the developed method could be used as a rapid and effective technique for the structural characterization of phytochem. constituents in SMW. This work is also expected to provide comprehensive information for the quality evaluation study of SMW. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Product Details of 3382-18-1).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. The discovery of chloroquine, the most well-known drug containing this stent, has helped bring about decades of malaria control and treatment.Product Details of 3382-18-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis of 2-pyridone derivatives bearing an electron-withdrawing group on nitrogen was written by Watanabe, Kazuhiro;Sato, Takeshi;Fujita, Reiko. And the article was included in Journal of Tohoku Pharmaceutical University in 2007.Reference of 27104-73-0 This article mentions the following:

1-Protected 2(1H)-pyridones are highly useful dienophiles because Diels-Alder reaction of 1-sulfonyl-2(1H)-pyridones gave the synthetic intermediate such as quinoline and isoquinoline derivatives Acylation of 2(1H)-pyridone bearing a methoxycarbonyl group at the 5- or 6-position with benzoyl chloride having some functional group (such as bromo, methoxy, nitro) gave 1-benzoylated 2(1H)-pyridone derivatives Further, the sulfonylation of 3-cyano- and 3-methoxycarbonyl-1(2H)-isouqinoliones afforded 2-sulfonylisoquinolone derivative In the experiment, the researchers used many compounds, for example, Methyl isoquinoline-3-carboxylate (cas: 27104-73-0Reference of 27104-73-0).

Methyl isoquinoline-3-carboxylate (cas: 27104-73-0) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. They are also used to make oil-soluble dyes, food colorants, pharmaceuticals, pH indicators and other organic compounds. Reference of 27104-73-0

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis and research of benzylamides of some isocyclic and heterocyclic acids as potential anticonvulsants was written by Strupinska, Marzanna;Rostafinska-Suchar, Grazyna;Pirianowicz-Chaber, Elzbieta;Stables, James P.;Jiang, Jeff;Paruszewski, Ryszard. And the article was included in Acta Poloniae Pharmaceutica in 2013.Synthetic Route of C10H7NO2 This article mentions the following:

A series of benzylamides of isocyclic and heterocyclic acids was synthesized and tested in anticonvulsant screening project (ASP) of antiepileptic drug development program of NIH. Near all synthesized derivatives of heterocyclic acids showed activity. All obtained derivatives of mono- and bicyclic isocyclic acids were inactive. The power of action of heterocyclic acids derivatives seems does not depend upon kind of heteroatom (N, O or S). One of the compounds (2-furoic acid benzylamide) appeared most promising. It showed in minimal clonic seizure (6Hz) test (ASP) in rats after i. p. administration: MES ED₅₀ = 36.5 mg/kg, TOX TD₅₀ = 269.75 mg/kg, and PI = 7.39. In the experiment, the researchers used many compounds, for example, Isoquinoline-1-carboxylic acid (cas: 486-73-7Synthetic Route of C10H7NO2).

Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Synthetic Route of C10H7NO2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Two asymmetrical perylene diimide derivatives: Synthesis, optical-electrochemical properties and morphologies of self-assembly was written by Tao, Jiayu;Zhang, Jiuxuan;Song, Yuting;Liu, Jian;Xu, Hai-Jun. And the article was included in Journal of Solid State Chemistry in 2022.Synthetic Route of C50H62N2O4 This article mentions the following:

In this manuscript, two PDI derivatives I [X = N] and I [X = O] with unsym. N-substitution of amine and ester-bridge were designed and synthesized. These two compounds were characterized by NMR, Fourier transform IR (FT-IR), and high-resolution mass spectrometry (HRMS). The photophys. properties were studied by UV-Vis absorption and fluorescence spectroscopy. Cyclic voltammograms of I [X = N] and I [X = O] were investigated and HOMO and LUMO energy levels of both two PDIs were estimated as -6.2 and -3.9 eV, resp. Thermal properties were also studied by thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC). I [X = N] was assembled into nanotubes while I [X = O] was assembled into nanobelts resp., via a reprecipitation method. I [X = N] and I [X = O] show good potential application in organic devices such as solar cells, organic field-effect transistors (OFETs) and so on. In the experiment, the researchers used many compounds, for example, 2,9-Di(tridecan-7-yl)anthra[2,1,9-def:6,5,10-d’e’f’]diisoquinoline-1,3,8,10(2H,9H)-tetraone (cas: 110590-84-6Synthetic Route of C50H62N2O4).

2,9-Di(tridecan-7-yl)anthra[2,1,9-def:6,5,10-d’e’f’]diisoquinoline-1,3,8,10(2H,9H)-tetraone (cas: 110590-84-6) belongs to isoquinoline derivatives. Isoquinoline is a structural isomer of quinoline, which have antiseptic, antipyretic and anti-cyclic properties, and can be used as antimalarial drugs and for the preparation of other antimalarial medicine. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Synthetic Route of C50H62N2O4

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Regioselective Cyanation of Six-Membered N-Heteroaromatic Compounds Under Metal-, Activator-, Base- and Solvent-Free Conditions was written by Sarmah, Bikash Kumar;Konwar, Monuranjan;Bhattacharyya, Dipanjan;Adhikari, Priyanka;Das, Animesh. And the article was included in Advanced Synthesis & Catalysis in 2019.Recommanded Product: 607-32-9 This article mentions the following:

A regioselective cyanation of heteroaromatic N-oxides with trimethylsilyl cyanide was developed to obtain 2-substituted N-heteroaromatic nitriles without the requirement of any external activator-, metal-, base- and solvent. The present protocol was a straightforward, one-pot heteroaromatic C-H cyanation process and proceeded smoothly in conventional heating but also under microwave irradiation with shorter reaction times. This approach now allowed access to a broad class of quinoline N-oxides and other heteroarene N-oxides with high to good yields and can also be scaled up to obtain gram quantities. Further application of this process was observed and utilized in late-stage cyanation of the anti-malarial drug quinine as well as transformation of the 2-cyanoazines to a series of biol. important mols. Based on the exptl. observations, a plausible mechanism was also proposed highlighting the dual role of trimethylsilyl cyanide as a nitrile source and as an activating agent. In the experiment, the researchers used many compounds, for example, 5-Nitroisoquinoline (cas: 607-32-9Recommanded Product: 607-32-9).

5-Nitroisoquinoline (cas: 607-32-9) belongs to isoquinoline derivatives. Quinoline and its derivatives are widely used as fungicides, biological agents, antibiotics, alkaloids, dyes, rubber chemicals and flavoring agents. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Recommanded Product: 607-32-9

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Discovery of the oncogenic MDM2, a direct binding target of berberine and a potential therapeutic, in multiple myeloma was written by Li, Chuting;Su, Ru;Wang, Xiuyuan;Huang, Guiping;Liu, Yanjun;Yang, Juhua;Yin, Zhao;Gu, Chunming;Fei, Jia. And the article was included in Functional & Integrative Genomics in 2022.Related Products of 2086-83-1 This article mentions the following:

Recent studies have suggested the potency of berberine (BBR) for multiple cancer treatments, including multiple myeloma (MM). However, the direct target and underlying mechanism of BBR remain largely understood in MM. Here, we demonstrated that BBR inhibited cell proliferation and acted synergistically with bortezomib in MM.1S cells. BBR treatment induced MM cell cycle arrest by downregulating several cell cycle-related proteins. Murine double minute 2 (MDM2) as a BBR-binding protein was identified by surface plasmon resonance image (SPRi) anal. and mol. docking. Overexpression of MDM2 is associated with MM progression and a poor prognosis. Knockdown MDM2 by siRNA transfection can repress MM malignant progression and attenuate the BBR sensitivity to MM.1S cells. BBR treatment induced the degradation of MDM2 through the ubiquitin-proteasome system and reactivated P53/P21 in MM cells. Overall, our data has illustrated that MDM2, as a binding protein of BBR for the first time, may serve as a potential therapeutic option for MM. In the experiment, the researchers used many compounds, for example, 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium (cas: 2086-83-1Related Products of 2086-83-1).

9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium (cas: 2086-83-1) belongs to isoquinoline derivatives. Although isoquinoline derivatives can be synthesized by several methods, relatively few direct methods deliver the unsubstituted isoquinoline. It protonates to form salts upon treatment with strong acids, such as HCl. It forms adducts with Lewis acids, such as BF3.Related Products of 2086-83-1

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis and structure-activity data of some new epibatidine analoges was written by Seerden, Jean-Paul G.;Tulp, Martin Th. M.;Scheeren, Hans W.;Kruse, Chris G.. And the article was included in Bioorganic & Medicinal Chemistry in 1998.HPLC of Formula: 55270-33-2 This article mentions the following:

The high-pressure Diels-Alder reaction of N-carbomethoxypyrroles and Ph vinyl sulfone affords versatile intermediates for the palladium-catalyzed preparation of new epibatidine analogs. Structure-activity relationships of new epibatidine analogs are presented. High affinities of K_i = 0.81 and 2.6 nM for the [³H]-cytisine rat brain nicotinic acetylcholine binding sites were found for the 5-pyrimidinyl and the 5-(2-amino)pyrimidinyl epibatidine analogs I (R = H, NH₂), resp. In the experiment, the researchers used many compounds, for example, 4-Iodoisoquinoline (cas: 55270-33-2HPLC of Formula: 55270-33-2).

4-Iodoisoquinoline (cas: 55270-33-2) belongs to isoquinoline derivatives. Quinoline is a mancude organic heterobicyclic parent, an azaarene, an ortho-fused heteroarene and a member of isoquinolines. Most traditional methods of generating isoquinoline do so via oxidative aromatization of dihydro- or tetrahydro-isoquinolines, usually offering some environmental or economic advantage.HPLC of Formula: 55270-33-2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem

Synthesis, cytotoxicity and docking simulation of bioactive [1,2,4]triazolo[3,4-a]dihydroisoquinoline chalcone derivatives was written by Teleb, Mohamed A. M.;Hassan, Nourhan;Hassaneen, Hamdi M.;Hassaneen, Huwaida M. E.;Laboud, Yara N.;Saleh, Fatma M.. And the article was included in Heterocycles in 2022.Synthetic Route of C11H13NO2 This article mentions the following:

1-(1-Aryl-8,9-dimethoxy-1,5,6,10b-tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)ethan-1-ones were prepared via reaction of C-acetylmethanohydrazonoyl chlorides with 6,7-dimethoxy-3,4-dihydroisoquinoline. Treatment of the latter products with 3-aryl-1-phenyl-1H-pyrazole-4-carbaldehyde derivatives in ethanol in the presence of sodium hydroxide solution at room temperature afforded chalcones I (X = Me, OMe; Y = H, Me, OMe, Cl). Cytotoxic assay was performed for in vitro antitumor screening against caucasian breast adenocarcinoma (MCF7) and hepatocellular carcinoma (HepG2) cell lines. Chalcones I (X = Y = Me) and I (X = OMe, Y = H) have promising cytotoxic effects against MCF7 with IC50 values 8.0 and 7.5渭g/mL, resp. Mol. docking using Mcule.com was carried out, for the most potent compounds I (X = Y = Me) and I (X = OMe, Y = H) against two protiens which are EGFR and DHFR. In the experiment, the researchers used many compounds, for example, 6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1Synthetic Route of C11H13NO2).

6,7-Dimethoxy-3,4-dihydroisoquinoline (cas: 3382-18-1) belongs to isoquinoline derivatives. Being an analog of pyridine, isoquinoline is a weak base, with a pKa of 5.14. Isoquinoline-type alkaloids show biological activities similar to those of morphinane-, protoberberine-, and benzophenanthridine-type alkaloids.Synthetic Route of C11H13NO2

Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem