Synthesis and research of benzylamides of some isocyclic and heterocyclic acids as potential anticonvulsants was written by Strupinska, Marzanna;Rostafinska-Suchar, Grazyna;Pirianowicz-Chaber, Elzbieta;Stables, James P.;Jiang, Jeff;Paruszewski, Ryszard. And the article was included in Acta Poloniae Pharmaceutica in 2013.Synthetic Route of C10H7NO2 This article mentions the following:
A series of benzylamides of isocyclic and heterocyclic acids was synthesized and tested in anticonvulsant screening project (ASP) of antiepileptic drug development program of NIH. Near all synthesized derivatives of heterocyclic acids showed activity. All obtained derivatives of mono- and bicyclic isocyclic acids were inactive. The power of action of heterocyclic acids derivatives seems does not depend upon kind of heteroatom (N, O or S). One of the compounds (2-furoic acid benzylamide) appeared most promising. It showed in minimal clonic seizure (6Hz) test (ASP) in rats after i. p. administration: MES ED50 = 36.5 mg/kg, TOX TD50 = 269.75 mg/kg, and PI = 7.39. In the experiment, the researchers used many compounds, for example, Isoquinoline-1-carboxylic acid (cas: 486-73-7Synthetic Route of C10H7NO2).
Isoquinoline-1-carboxylic acid (cas: 486-73-7) belongs to isoquinoline derivatives. The isoquinoline structure occurs in a considerable number of alkaloids in widely separated plant families. Lewis acid activation and nucleophilic attack can produce multiple regioisomers in quinolines and pyridines; isoquinolines generally only undergo attack at the 1-position.Synthetic Route of C10H7NO2
Referemce:
Isoquinoline – Wikipedia,
Isoquinoline | C9H7N – PubChem